Protein: MED15
Mediator of RNA polymerase II transcription subunit 15 (Autonomous replication regulatory protein 3) (Basal expression activator protein 1) (Defective silencing suppressor protein 4) (Mediator complex subunit 15) (Transcription regulatory protein GAL11) (Ty insertion suppressor protein 13)

Gene: MED15, GAL11
Organism: Saccharomyces cerevisiae S288C
Interactions: 125
UniProt ID: P19659

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001095 - TFIIE-class transcription factor complex binding
GO:0001097 - TFIIH-class transcription factor complex binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

408390

GAL4
Regulatory protein GAL4

13

1

Small-scale

0.762

High

624881

MED18
Mediator of RNA polymerase II transcription subunit 18

15

0

Small-scale

0.727

High

395223

GCN4
General control transcription factor GCN4

7

0

Small-scale

0.719

High

619395

MED14
Mediator of RNA polymerase II transcription subunit 14

10

0

Small-scale

0.717

High

624879

MED17
Mediator of RNA polymerase II transcription subunit 17

10

0

Small-scale

0.717

High

624875

MED16
Mediator of RNA polymerase II transcription subunit 16

9

0

Small-scale

0.716

High

624948

MED7
Mediator of RNA polymerase II transcription subunit 7

8

0

Small-scale

0.714

High

624918

MED3
Mediator of RNA polymerase II transcription subunit 3

8

0

Small-scale

0.714

High

624904

MED8
Mediator of RNA polymerase II transcription subunit 8

8

0

Small-scale

0.711

High

624949

MED2
Mediator of RNA polymerase II transcription subunit 2

8

0

Small-scale

0.711

High

624880

MED22
Mediator of RNA polymerase II transcription subunit 22

6

0

Small-scale

0.697

High

624891

MED20
Mediator of RNA polymerase II transcription subunit 20

6

0

Small-scale

0.696

High

624868

MED19
Mediator of RNA polymerase II transcription subunit 19

6

0

Small-scale

0.695

High

624953

MED1
Mediator of RNA polymerase II transcription subunit 1

5

0

Small-scale

0.676

High

624897

T2EA
Transcription initiation factor IIE subunit alpha

4

0

Small-scale

0.669

High

624931

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.661

High

624955

MED4
Mediator of RNA polymerase II transcription subunit 4

4

0

Small-scale

0.661

High

624898

T2EB
Transcription initiation factor IIE subunit beta

3

0

Small-scale

0.654

High

624887

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.653

High

624926

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.653

High

553511

PDR1
Transcription factor PDR1

2

1

Small-scale

0.650

High

624907

MED31
Mediator of RNA polymerase II transcription subunit 31

4

0

Small-scale

0.649

High

624908

MED6
Mediator of RNA polymerase II transcription subunit 6

4

0

Small-scale

0.649

High

401876

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

0

Small-scale

0.632

High

624945

MED10
Mediator of RNA polymerase II transcription subunit 10

3

0

Small-scale

0.625

High

523011

HSP71
Heat shock protein SSA1

3

1

High-throughput

0.624

High

624890

MSN2
Zinc finger protein MSN2

3

0

Small-scale

0.618

High

624946

CDC73
Cell division control protein 73

3

0

Small-scale

0.614

High

624892

TAF14
Transcription initiation factor TFIID subunit 14

2

0

Small-scale

0.581

High

624935

GCN5
Histone acetyltransferase GCN5

2

0

High-throughput

0.576

High

594173

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.561

High

624874

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.561

High

624936

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

2

0

Small-scale

0.561

High

624914

SSN3
Meiotic mRNA stability protein kinase SSN3

2

0

Small-scale

0.559

High

624951

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

624929

MSN5
Protein MSN5

1

0

High-throughput

0.513

High

624957

SUS1
SAGA complex subunit SUS1

1

0

High-throughput

0.513

High

419587

H2A2
Histone H2A.2

1

0

High-throughput

0.493

High

624934

IMA1
Importin subunit alpha

1

0

High-throughput

0.493

High

624943

IMB1
Importin subunit beta-1

1

0

High-throughput

0.493

High

624947

ESC8
Protein ESC8

1

0

Small-scale

0.486

High

624899

CCL1
Cyclin CCL1

1

1

Small-scale

0.481

High

466773

SWI5
Transcriptional factor SWI5

1

0

Small-scale

0.480

High

624876

BTAF1
TATA-binding protein-associated factor MOT1

1

1

Small-scale

0.479

High

624886

PDR3
Transcription factor PDR3

1

1

Small-scale

0.479

High

624925

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

1

High-throughput

0.479

High

548815

TAF13
Transcription initiation factor TFIID subunit 13

1

0

Small-scale

0.460

High

561414

TBP
TATA-box-binding protein

1

0

Small-scale

0.460

High

614792

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

Small-scale

0.460

High

617765

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.460

High

624863

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

Small-scale

0.460

High

624864

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

Small-scale

0.460

High

624865

SNF2
Transcription regulatory protein SNF2

1

0

Small-scale

0.460

High

624871

MIG1
Regulatory protein MIG1

1

0

Small-scale

0.460

High

624872

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

Small-scale

0.460

High

624882

T2AG
Transcription initiation factor IIA subunit 2

1

0

Small-scale

0.460

High

624883

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

Small-scale

0.460

High

624885

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

624911

SPT8
SAGA complex subunit SPT8

1

0

Small-scale

0.460

High

624913

SNF11
Transcription regulatory protein SNF11

1

0

Small-scale

0.460

High

624919

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

Small-scale

0.460

High

624928

TAF4
Transcription initiation factor TFIID subunit 4

1

0

Small-scale

0.460

High

624938

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.460

High

624940

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.460

High

624941

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

Small-scale

0.460

High

624942

ARP9
Actin-like protein ARP9

1

0

Small-scale

0.460

High

624956

ARP7
Actin-related protein 7

1

0

Small-scale

0.460

High

434808

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

578817

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

624866

AFT1
Iron-regulated transcriptional activator AFT1

1

0

Small-scale

0.458

High

624867

TAF2
Transcription initiation factor TFIID subunit 2

1

0

Small-scale

0.458

High

624877

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

624884

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

624888

TKT2
Transketolase 2

1

0

High-throughput

0.458

High

624893

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

624894

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

624895

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

624900

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

624903

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

624905

PAF1
RNA polymerase II-associated protein 1

1

0

Small-scale

0.458

High

624906

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

624910

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

0

Small-scale

0.458

High

624912

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.458

High

624920

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

624921

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

624922

MGA2
Protein MGA2

1

0

Small-scale

0.458

High

624923

T2FB
Transcription initiation factor IIF subunit beta

1

0

Small-scale

0.458

High

624924

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.458

High

624930

TEL2
Telomere length regulation protein TEL2

1

0

Small-scale

0.458

High

624933

HAP5
Transcriptional activator HAP5

1

0

Small-scale

0.458

High

624937

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

624944

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

624950

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

624952

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

624958

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

525885

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

543769

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

624917

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

624909

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

624870

INO2
Protein INO2

1

0

Small-scale

0.391

High

624878

MET4
Transcriptional activator of sulfur metabolism MET4

1

0

Small-scale

0.391

High

624939

SSL1
General transcription and DNA repair factor IIH subunit SSL1

1

0

Small-scale

0.251

Low

149573

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

360944

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

383508

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

433436

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

435760

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

441695

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

454863

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

502840

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504029

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

512247

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

512806

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514446

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

624869

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

624873

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.249

Low

624889

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

624896

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

624901

PDX3
Pyridoxamine 5'-phosphate oxidase

1

0

High-throughput

0.249

Low

624902

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low

624915

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

624916

GDI1
Rab GDP-dissociation inhibitor

1

0

High-throughput

0.249

Low

624927

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

624932

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

624954

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025