Protein: MLH1
DNA mismatch repair protein MLH1 (MutL protein homolog 1) (Post meiotic segregation protein 2)

Gene: MLH1
Organism: Saccharomyces cerevisiae S288C
Interactions: 41
UniProt ID: P38920

Gene Ontology (top 5):
GO:0000710 - meiotic mismatch repair
GO:0000713 - meiotic heteroduplex formation
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571277

PMS1
DNA mismatch repair protein PMS1

29

14

Small-scale

0.993

High

807649

MLH3
DNA mismatch repair protein MLH3

13

14

Small-scale

0.983

High

807646

MLH2
DNA mismatch repair protein MLH2

8

14

Small-scale

0.969

High

682916

MSH2
DNA mismatch repair protein MSH2

7

20

Small-scale

0.963

High

807644

MSH6
DNA mismatch repair protein MSH6

5

20

Small-scale

0.919

High

672012

MSH3
DNA mismatch repair protein MSH3

2

20

Small-scale

0.778

High

807637

MLH1
DNA mismatch repair protein MLH1

2

14

Small-scale

0.778

High

526678

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.776

High

807638

EXO1
Exodeoxyribonuclease 1

10

5

Small-scale

0.755

High

523931

HSP71
Heat shock protein SSA1

2

5

Small-scale

0.712

High

763280

SGS1
ATP-dependent helicase SGS1

5

2

Small-scale

0.704

High

807640

HFM1
ATP-dependent DNA helicase MER3

3

3

Small-scale

0.669

High

807647

NTH2
Endonuclease III homolog 2

3

0

Small-scale

0.654

High

807651

MSH5
MutS protein homolog 5

1

20

Small-scale

0.647

High

586457

PCNA
Proliferating cell nuclear antigen

2

5

Small-scale

0.605

High

510482

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.575

High

544851

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.575

High

804157

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.575

High

807643

ABF2
ARS-binding factor 2, mitochondrial

1

1

High-throughput

0.541

High

675331

RAD51
DNA repair protein RAD51

1

3

High-throughput

0.536

High

792800

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.513

High

800341

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.513

High

807653

ISN1
IMP-specific 5'-nucleotidase 1

1

0

High-throughput

0.513

High

425127

OTC
Ornithine carbamoyltransferase

1

1

High-throughput

0.500

High

807648

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

1

High-throughput

0.500

High

746092

RAD5
DNA repair protein RAD5

1

4

Small-scale

0.481

High

554923

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.479

High

707078

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

739962

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

1

High-throughput

0.479

High

800991

RFC1
Replication factor C subunit 1

1

6

Small-scale

0.479

High

807639

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

807645

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

807650

RTK1
Probable serine/threonine-protein kinase RTK1

1

1

High-throughput

0.479

High

435088

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

453023

CBP8
Cytochrome B pre-mRNA-processing protein 1

1

0

High-throughput

0.458

High

807641

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.458

High

807642

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

807652

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

453596

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

727021

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High


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Last updated: 11Aug2025