Protein: MGMT
Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (DNA repair MTase) (O-6-methylguanine-DNA-alkyltransferase)

Gene: MGMT, MGT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 55
UniProt ID: P26188

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003908 - methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO:0005634 - nucleus
GO:0005777 - peroxisome
GO:0006307 - DNA alkylation repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

684063

UFD4
Ubiquitin fusion degradation protein 4

2

0

Small-scale

0.612

High

380991

H2B1
Histone H2B.1

1

1

High-throughput

0.536

High

684072

DUN1
DNA damage response protein kinase DUN1

1

1

High-throughput

0.536

High

684079

H3
Histone H3

1

2

High-throughput

0.536

High

575900

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.513

High

684067

AHP1
Peroxiredoxin AHP1

1

0

High-throughput

0.513

High

684082

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

486059

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.500

High

679427

CDC48
Cell division control protein 48

1

1

High-throughput

0.500

High

684070

KSP1
Serine/threonine-protein kinase KSP1

1

1

High-throughput

0.500

High

684078

ACT
Actin

1

1

High-throughput

0.500

High

684066

LHS1
Heat shock protein 70 homolog LHS1

1

1

High-throughput

0.489

High

408296

GAL1
Galactokinase

1

0

High-throughput

0.479

High

470475

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.479

High

590554

HSP26
Heat shock protein 26

1

0

High-throughput

0.479

High

675758

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.479

High

684061

RPN2
26S proteasome regulatory subunit RPN2

1

0

High-throughput

0.479

High

684080

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.479

High

684083

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.479

High

366954

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.457

High

386592

TBB
Tubulin beta chain

1

1

High-throughput

0.457

High

425112

OTC
Ornithine carbamoyltransferase

1

1

High-throughput

0.457

High

452837

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.457

High

592054

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.457

High

626619

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.457

High

661586

MPCP
Mitochondrial phosphate carrier protein

1

2

High-throughput

0.457

High

684062

HSP7F
Heat shock protein homolog SSE1

1

1

High-throughput

0.445

High

523217

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

544002

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

510250

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

578949

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.407

High

625941

UBR1
E3 ubiquitin-protein ligase UBR1

4

0

Small-scale

0.364

High

465320

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.279

Low

536085

ARF1
ADP-ribosylation factor 1

1

0

High-throughput

0.279

Low

684064

DCA13
Protein SOF1

1

0

High-throughput

0.279

Low

684065

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.279

Low

684068

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.279

Low

684069

YHJ3
Uncharacterized protein YHR033W

1

0

High-throughput

0.279

Low

684071

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.279

Low

684074

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.279

Low

684076

GPG1
Heterotrimeric G protein gamma subunit GPG1

1

0

High-throughput

0.279

Low

684077

EF3B
Elongation factor 3B

1

0

High-throughput

0.279

Low

368606

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

416388

HXKA
Hexokinase-1

1

0

High-throughput

0.261

Low

450534

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.261

Low

453450

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.261

Low

531258

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.261

Low

555023

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

585534

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

598967

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.261

Low

644722

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

684073

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

684075

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.261

Low

684081

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

0

High-throughput

0.261

Low

644613

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025