Protein: ERB1
Ribosome biogenesis protein ERB1 (Eukaryotic ribosome biogenesis protein 1)

Gene: ERB1
Organism: Saccharomyces cerevisiae S288C
Interactions: 225
UniProt ID: Q04660

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

918988

PESC
Pescadillo homolog

21

4

Small-scale

0.989

High

1047302

YTM1
Ribosome biogenesis protein YTM1

13

20

Small-scale

0.985

High

1043277

HAS1
ATP-dependent RNA helicase HAS1

8

16

High-throughput

0.967

High

782444

RPF2
Ribosome biogenesis protein RPF2

8

1

Small-scale

0.965

High

682380

SPB4
ATP-dependent rRNA helicase SPB4

7

14

High-throughput

0.960

High

804660

SSF1
Ribosome biogenesis protein SSF1

6

2

Small-scale

0.932

High

1047308

DBP10
ATP-dependent RNA helicase DBP10

5

13

High-throughput

0.909

High

746672

DRS1
ATP-dependent RNA helicase DRS1

4

15

High-throughput

0.903

High

1047294

BRX1
Ribosome biogenesis protein BRX1

4

9

High-throughput

0.900

High

793529

MAK5
ATP-dependent RNA helicase MAK5

3

17

High-throughput

0.855

High

633189

MAK11
Protein MAK11

3

18

Small-scale

0.847

High

780317

EBP2
rRNA-processing protein EBP2

3

3

Small-scale

0.839

High

738255

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

3

7

High-throughput

0.839

High

917477

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

2

7

High-throughput

0.811

High

1047274

ERB1
Ribosome biogenesis protein ERB1

2

16

High-throughput

0.776

High

917557

NSA1
Ribosome biogenesis protein NSA1

10

2

Small-scale

0.753

High

814382

NOC2
Nucleolar complex protein 2

8

1

Small-scale

0.752

High

816901

NUG1
Nuclear GTP-binding protein NUG1

9

8

Small-scale

0.750

High

816796

NOP16
Nucleolar protein 16

2

0

High-throughput

0.748

High

827604

RLP7
Ribosome biogenesis protein RLP7

7

6

Small-scale

0.747

High

1039628

NOG1
Nucleolar GTP-binding protein 1

7

6

Small-scale

0.745

High

677240

SPB1
27S pre-rRNA

2

6

High-throughput

0.737

High

751482

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

3

High-throughput

0.737

High

805091

RPF1
Ribosome production factor 1

2

1

High-throughput

0.737

High

830180

NOP2
25S rRNA

6

5

Small-scale

0.732

High

803933

CIC1
Proteasome-interacting protein CIC1

6

4

Small-scale

0.729

High

923204

NOG2
Nucleolar GTP-binding protein 2

6

8

Small-scale

0.723

High

1047310

IF6
Eukaryotic translation initiation factor 6

5

1

Small-scale

0.718

High

924844

NOP15
Ribosome biogenesis protein 15

5

11

High-throughput

0.716

High

1047306

MAK21
Ribosome biogenesis protein MAK21

5

7

High-throughput

0.712

High

793994

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

17

High-throughput

0.691

High

1030574

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

11

High-throughput

0.691

High

1042369

GCN5
Histone acetyltransferase GCN5

1

17

High-throughput

0.691

High

1046246

UTP15
U3 small nucleolar RNA-associated protein 15

1

17

High-throughput

0.691

High

791108

NOP4
Nucleolar protein 4

4

8

High-throughput

0.691

High

818274

NSA2
Ribosome biogenesis protein NSA2

4

2

Small-scale

0.691

High

865069

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.675

High

1047282

FKBP4
FK506-binding protein 4

3

7

High-throughput

0.667

High

1044899

RRP17
Ribosomal RNA-processing protein 17

4

0

High-throughput

0.657

High

750146

MRT4
Ribosome assembly factor MRT4

3

6

Small-scale

0.656

High

1047276

RRP5
rRNA biogenesis protein RRP5

3

10

High-throughput

0.656

High

1046510

PUF6
Pumilio homology domain family member 6

3

2

Small-scale

0.650

High

758254

URB1
Nucleolar pre-ribosomal-associated protein 1

3

0

Small-scale

0.642

High

1047309

NOP58
Nucleolar protein 58

3

6

High-throughput

0.633

High

668296

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.631

High

743284

PP12
Serine/threonine-protein phosphatase PP1-2

2

6

High-throughput

0.628

High

850016

LOC1
60S ribosomal subunit assembly/export protein LOC1

3

0

High-throughput

0.622

High

811162

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.618

High

419869

H2A2
Histone H2A.2

1

7

High-throughput

0.618

High

673591

NLE1
Ribosome assembly protein 4

1

17

Small-scale

0.618

High

781652

DBP7
ATP-dependent RNA helicase DBP7

1

13

Small-scale

0.618

High

792243

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.618

High

864515

MTR4
ATP-dependent RNA helicase DOB1

1

13

Small-scale

0.618

High

897505

UBC9
SUMO-conjugating enzyme UBC9

1

6

High-throughput

0.618

High

1046025

DHR1
Probable ATP-dependent RNA helicase DHR1

1

9

High-throughput

0.618

High

1047278

HRQ1
ATP-dependent helicase HRQ1

1

15

Small-scale

0.618

High

1047284

DBP9
ATP-dependent RNA helicase DBP9

1

9

High-throughput

0.618

High

1047305

SSF2
Ribosome biogenesis protein SSF2

1

2

High-throughput

0.618

High

1047311

H2AZ
Histone H2A.Z

1

6

High-throughput

0.618

High

806656

RIX1
Pre-rRNA-processing protein RIX1

3

0

Small-scale

0.613

High

570141

RL3
Large ribosomal subunit protein uL3

2

5

High-throughput

0.611

High

924329

NOP13
Nucleolar protein 13

2

9

High-throughput

0.611

High

1047290

NOC3
Nucleolar complex-associated protein 3

2

4

High-throughput

0.611

High

456549

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

1

High-throughput

0.595

High

763117

RRP1
Ribosomal RNA-processing protein 1

2

6

Small-scale

0.584

High

798305

ENP1
Essential nuclear protein 1

2

1

High-throughput

0.584

High

844605

UTP10
U3 small nucleolar RNA-associated protein 10

2

2

High-throughput

0.584

High

1047291

RLP24
Ribosome biogenesis protein RLP24

2

3

Small-scale

0.584

High

626882

HSP60
Heat shock protein 60, mitochondrial

1

20

High-throughput

0.578

High

1047277

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

2

High-throughput

0.575

High

671109

SIS1
Protein SIS1

2

11

High-throughput

0.571

High

826824

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

383893

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.553

High

874524

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.553

High

525107

HSP71
Heat shock protein SSA1

2

9

High-throughput

0.552

High

819759

SSB2
Ribosome-associated molecular chaperone SSB2

2

9

High-throughput

0.552

High

924727

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

0

Small-scale

0.551

High

438488

EIF3B
Eukaryotic translation initiation factor 3 subunit B

2

2

High-throughput

0.537

High

444796

SIR2
NAD-dependent histone deacetylase SIR2

1

7

High-throughput

0.536

High

531886

RL4A
Large ribosomal subunit protein uL4A

1

5

High-throughput

0.536

High

546228

SSB1
Ribosome-associated molecular chaperone SSB1

1

9

High-throughput

0.536

High

586019

CSK21
Casein kinase II subunit alpha

1

16

High-throughput

0.536

High

623011

CSK22
Casein kinase II subunit alpha'

1

17

High-throughput

0.536

High

676675

SGF29
SAGA complex subunit SGF29

1

2

High-throughput

0.536

High

722249

XPO1
Exportin-1

1

11

High-throughput

0.536

High

763020

SPT7
SAGA complex subunit SPT7

1

14

High-throughput

0.536

High

806497

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.536

High

810664

SSN3
Meiotic mRNA stability protein kinase SSN3

1

12

High-throughput

0.536

High

1026828

CDC14
Tyrosine-protein phosphatase CDC14

1

7

High-throughput

0.536

High

1036130

PVH1
Tyrosine-protein phosphatase YVH1

1

2

High-throughput

0.536

High

1047307

HSP42
Heat shock protein 42

2

2

High-throughput

0.533

High

585370

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

5

High-throughput

0.515

High

1042996

STE20
Serine/threonine-protein kinase STE20

1

16

High-throughput

0.515

High

924030

ELOA1
Elongin-A

1

0

High-throughput

0.513

High

1045062

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.513

High

1047289

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

510804

HSP77
Import motor subunit, mitochondrial

2

11

High-throughput

0.504

High

656614

KC11
Casein kinase I homolog 1

1

7

High-throughput

0.501

High

748894

SWE1
Mitosis inhibitor protein kinase SWE1

1

7

High-throughput

0.501

High

590722

HSP26
Heat shock protein 26

1

1

High-throughput

0.500

High

597270

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.500

High

680053

CDC48
Cell division control protein 48

1

4

High-throughput

0.500

High

750895

PRS6B
26S proteasome regulatory subunit 6B homolog

1

6

High-throughput

0.500

High

1047312

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.493

High

622393

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.489

High

802974

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

1

High-throughput

0.489

High

815749

SAHH
Adenosylhomocysteinase

1

3

High-throughput

0.489

High

818198

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

1

High-throughput

0.489

High

858129

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.489

High

866036

YMR1
Phosphoinositide 3-phosphatase

1

3

High-throughput

0.489

High

871507

ASK10
Activator of SKN7 protein 10

1

1

High-throughput

0.489

High

923124

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.489

High

1033863

KIN4
Serine/threonine-protein kinase KIN4

1

5

High-throughput

0.489

High

1040422

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

10

High-throughput

0.489

High

1042317

PKH3
Serine/threonine-protein kinase PKH3

1

4

High-throughput

0.489

High

1047279

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

12

High-throughput

0.489

High

1047280

RGC1
Regulator of the glycerol channel 1

1

1

High-throughput

0.489

High

1047296

HRK1
Serine/threonine-protein kinase HRK1

1

4

High-throughput

0.489

High

1047304

RTK1
Probable serine/threonine-protein kinase RTK1

1

5

High-throughput

0.489

High

149952

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

410336

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

433843

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.479

High

435355

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

436170

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

436514

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

5

High-throughput

0.479

High

442107

RS14A
Small ribosomal subunit protein uS11A

1

5

High-throughput

0.479

High

512647

RS6A
Small ribosomal subunit protein eS6A

1

4

High-throughput

0.479

High

534141

MAK16
Protein MAK16

1

2

High-throughput

0.479

High

644988

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

High-throughput

0.479

High

674834

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

677558

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

689656

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

709974

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

782184

LAS1
Protein LAS1

1

1

Small-scale

0.479

High

794301

PPS1
Dual specificity protein phosphatase PPS1

1

2

High-throughput

0.479

High

807144

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

9

High-throughput

0.479

High

823036

ATAD2
ATPase histone chaperone YTA7

1

6

High-throughput

0.479

High

826077

ULP2
Ubiquitin-like-specific protease 2

1

5

High-throughput

0.479

High

864959

NOP9
Nucleolar protein 9

1

1

Small-scale

0.479

High

919556

SDA1
Protein SDA1

1

1

High-throughput

0.479

High

919775

YG5X
Putative methyltransferase YGR283C

1

1

High-throughput

0.479

High

923062

TR112
Multifunctional methyltransferase subunit TRM112

1

1

Small-scale

0.479

High

925042

APJ1
J domain-containing protein APJ1

1

13

High-throughput

0.479

High

925447

RCM1
25S rRNA

1

5

High-throughput

0.479

High

932230

ORC1
Origin recognition complex subunit 1

1

4

High-throughput

0.479

High

1038750

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.479

High

1042226

TOM1
E3 ubiquitin-protein ligase TOM1

1

7

High-throughput

0.479

High

1046785

UTP14
U3 small nucleolar RNA-associated protein 14

1

9

High-throughput

0.479

High

1046925

POB3
FACT complex subunit POB3

1

7

High-throughput

0.479

High

1047275

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.479

High

1047283

JIP5
WD repeat-containing protein JIP5

1

18

High-throughput

0.479

High

1047287

NOC4
Nucleolar complex protein 4

1

7

High-throughput

0.479

High

1047293

NOP12
Nucleolar protein 12

1

12

High-throughput

0.479

High

1047298

RRS1
Regulator of ribosome biosynthesis

1

2

High-throughput

0.479

High

1047299

NIP7
60S ribosome subunit biogenesis protein NIP7

1

2

High-throughput

0.479

High

1047301

MDN1
Midasin

1

15

High-throughput

0.479

High

1047303

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.479

High

739772

SPT16
FACT complex subunit SPT16

1

5

High-throughput

0.470

High

439428

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

708142

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

735158

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

748039

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

780707

RRP14
Ribosomal RNA-processing protein 14

1

0

High-throughput

0.458

High

795844

YBC8
UPF0642 protein YBL028C

1

0

High-throughput

0.458

High

808908

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

865416

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.458

High

1044306

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

1047281

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

1047285

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

1047286

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.458

High

1047295

SGO1
Shugoshin

1

0

High-throughput

0.458

High

917165

ATG1
Serine/threonine-protein kinase ATG1

1

7

High-throughput

0.457

High

359529

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.457

High

367118

ATPB
ATP synthase subunit beta, mitochondrial

1

6

High-throughput

0.457

High

367811

ENO1
Enolase 1

1

3

High-throughput

0.457

High

405143

LEU3
3-isopropylmalate dehydrogenase

1

4

High-throughput

0.457

High

408591

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

1

High-throughput

0.457

High

555153

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.457

High

527645

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

742369

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

795921

LSM2
LSM complex subunit LSM2

1

9

High-throughput

0.445

High

804443

SSZ1
Ribosome-associated complex subunit SSZ1

1

8

High-throughput

0.445

High

811392

CAJ1
Protein CAJ1

1

13

High-throughput

0.445

High

863989

JJJ2
J protein JJJ2

1

10

High-throughput

0.445

High

455256

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.437

High

503236

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

504411

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

511290

RL20B
Large ribosomal subunit protein eL20B

1

2

High-throughput

0.437

High

513214

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

514833

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

671341

CANB
Calcineurin subunit B

1

3

High-throughput

0.437

High

747575

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

753583

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

778527

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

802383

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

918453

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

1025036

NUM1
Nuclear migration protein NUM1

1

10

High-throughput

0.437

High

1033560

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

1047297

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

807271

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.426

High

808229

SNF11
Transcription regulatory protein SNF11

1

0

High-throughput

0.426

High

844392

SERB
Phosphoserine phosphatase

1

0

High-throughput

0.426

High

394896

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

580042

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.407

High

671706

SCJ1
DnaJ-related protein SCJ1

1

10

High-throughput

0.407

High

824547

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.407

High

432363

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.279

Low

455523

PMM
Phosphomannomutase

1

0

High-throughput

0.279

Low

662704

EXG1
Glucan 1,3-beta-glucosidase I/II

1

0

High-throughput

0.279

Low

808998

HXT7
High-affinity hexose transporter HXT7

1

0

High-throughput

0.279

Low

918069

PIB2
Glutamine sensor PIB2

1

0

High-throughput

0.279

Low

1041488

MUB1
MYND-type zinc finger protein MUB1

1

0

High-throughput

0.279

Low

1047292

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

High-throughput

0.279

Low

1047300

THI21
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21

1

0

High-throughput

0.279

Low

805876

YHT8
Uncharacterized protein YHR138C

1

0

High-throughput

0.269

Low

692431

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.261

Low

1044006

ENT5
Epsin-5

1

0

Small-scale

0.261

Low

368752

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.261

Low

572648

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.261

Low

607789

HXKG
Glucokinase-1

1

0

High-throughput

0.261

Low

807845

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

812642

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

1047288

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

752715

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025