Protein: RRP46
Exosome complex component RRP46 (Ribosomal RNA-processing protein 46)

Gene: RRP46
Organism: Saccharomyces cerevisiae S288C
Interactions: 85
UniProt ID: P53256

Gene Ontology (top 5):
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

918904

RRP44
Exosome complex exonuclease DIS3

15

16

Small-scale

0.983

High

918880

CSL4
Exosome complex component CSL4

15

11

Small-scale

0.983

High

863114

RRP41
Exosome complex component SKI6

13

18

Small-scale

0.980

High

672919

RRP43
Exosome complex component RRP43

12

2

Small-scale

0.980

High

804730

RRP4
Exosome complex component RRP4

9

20

Small-scale

0.970

High

918892

RRP45
Exosome complex component RRP45

9

20

Small-scale

0.970

High

918905

RRP40
Exosome complex component RRP40

9

11

Small-scale

0.970

High

871109

MTR3
Exosome complex component MTR3

7

1

Small-scale

0.960

High

918875

RRP46
Exosome complex component RRP46

3

16

Small-scale

0.830

High

918911

RRP6
Exosome complex exonuclease RRP6

12

10

Small-scale

0.757

High

918914

RRP42
Exosome complex component RRP42

10

20

Small-scale

0.754

High

804942

LRP1
Exosome complex protein LRP1

6

2

Small-scale

0.729

High

918878

MPP6
M-phase phosphoprotein 6 homolog

4

2

Small-scale

0.696

High

918906

SKI7
Superkiller protein 7

10

7

Small-scale

0.687

High

918787

UTP22
U3 small nucleolar RNA-associated protein 22

3

3

High-throughput

0.643

High

798272

ENP1
Essential nuclear protein 1

3

2

High-throughput

0.640

High

918887

DHR1
Probable ATP-dependent RNA helicase DHR1

3

2

High-throughput

0.640

High

819352

SSB2
Ribosome-associated molecular chaperone SSB2

3

5

High-throughput

0.611

High

918884

IMA1
Importin subunit alpha

2

1

High-throughput

0.588

High

677498

KRR1
KRR1 small subunit processome component

2

2

High-throughput

0.584

High

844548

UTP10
U3 small nucleolar RNA-associated protein 10

2

2

High-throughput

0.584

High

864481

MTR4
ATP-dependent RNA helicase DOB1

2

17

Small-scale

0.584

High

918889

UTP14
U3 small nucleolar RNA-associated protein 14

2

3

High-throughput

0.584

High

918899

NOC4
Nucleolar complex protein 4

2

2

High-throughput

0.584

High

527262

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

623908

MYO2
Myosin-2

2

1

High-throughput

0.537

High

524656

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.536

High

918877

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.513

High

603087

EST1
Telomere elongation protein EST1

1

2

High-throughput

0.479

High

609076

SKI3
Superkiller protein 3

1

3

High-throughput

0.479

High

673207

RRP7
Ribosomal RNA-processing protein 7

1

2

High-throughput

0.479

High

678429

PWP2
Periodic tryptophan protein 2

1

17

High-throughput

0.479

High

707734

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

754310

DCA13
Protein SOF1

1

12

High-throughput

0.479

High

758391

UTP11
U3 small nucleolar RNA-associated protein 11

1

2

High-throughput

0.479

High

763598

UTP20
U3 small nucleolar RNA-associated protein 20

1

2

High-throughput

0.479

High

776618

DEF1
RNA polymerase II degradation factor 1

1

3

High-throughput

0.479

High

806547

UTP9
U3 small nucleolar RNA-associated protein 9

1

2

High-throughput

0.479

High

817600

UTP7
U3 small nucleolar RNA-associated protein 7

1

8

High-throughput

0.479

High

823362

UTP18
U3 small nucleolar RNA-associated protein 18

1

3

High-throughput

0.479

High

826196

FAF1
Protein FAF1

1

1

High-throughput

0.479

High

836190

DIM1
Dimethyladenosine transferase

1

2

High-throughput

0.479

High

852582

ROK1
ATP-dependent RNA helicase ROK1

1

1

High-throughput

0.479

High

865145

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

2

High-throughput

0.479

High

918876

UTP8
U3 small nucleolar RNA-associated protein 8

1

2

High-throughput

0.479

High

918881

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.479

High

918882

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

2

High-throughput

0.479

High

918883

UTP6
U3 small nucleolar RNA-associated protein 6

1

2

High-throughput

0.479

High

918885

UTP17
NET1-associated nuclear protein 1

1

18

High-throughput

0.479

High

918886

UTP5
U3 small nucleolar RNA-associated protein 5

1

17

High-throughput

0.479

High

918888

UTP15
U3 small nucleolar RNA-associated protein 15

1

13

High-throughput

0.479

High

918890

RRP5
rRNA biogenesis protein RRP5

1

7

High-throughput

0.479

High

918891

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

918894

UTP13
U3 small nucleolar RNA-associated protein 13

1

20

High-throughput

0.479

High

918895

UTP21
U3 small nucleolar RNA-associated protein 21

1

18

High-throughput

0.479

High

918896

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

2

High-throughput

0.479

High

918898

RRP9
Ribosomal RNA-processing protein 9

1

14

High-throughput

0.479

High

918900

BFR2
Protein BFR2

1

2

High-throughput

0.479

High

918902

UTP4
U3 small nucleolar RNA-associated protein 4

1

15

High-throughput

0.479

High

918903

RCL1
rRNA processing protein RCL1

1

2

High-throughput

0.479

High

918907

UTP16
U3 small nucleolar RNA-associated protein 16

1

2

High-throughput

0.479

High

918908

BMS1
Ribosome biogenesis protein BMS1

1

2

High-throughput

0.479

High

918909

FCF2
rRNA-processing protein FCF2

1

3

High-throughput

0.479

High

918910

SAS10
Something about silencing protein 10

1

3

High-throughput

0.479

High

918913

UTP12
U3 small nucleolar RNA-associated protein 12

1

20

High-throughput

0.479

High

918915

NOP56
Nucleolar protein 56

1

5

High-throughput

0.479

High

918916

NOP58
Nucleolar protein 58

1

5

High-throughput

0.479

High

918917

NOP14
Nucleolar complex protein 14

1

2

High-throughput

0.479

High

632100

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.458

High

825065

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

918897

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

918912

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

918918

PNO1
Pre-rRNA-processing protein PNO1

1

0

Small-scale

0.458

High

403594

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.445

High

545689

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

742050

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

763845

SKI2
Antiviral helicase SKI2

1

17

High-throughput

0.437

High

427378

RLA0
Large ribosomal subunit protein uL10

1

4

High-throughput

0.407

High

893190

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.407

High

918893

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

9

High-throughput

0.407

High

918879

IST1
Vacuolar protein sorting-associated protein IST1

2

0

High-throughput

0.307

High

918901

CENPO
Inner kinetochore subunit MCM21

1

0

High-throughput

0.249

Low

579794

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

863668

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025