Protein: IF2B
Eukaryotic translation initiation factor 2 subunit beta (eIF2-beta)

Gene: IF2B, SUI3
Organism: Saccharomyces cerevisiae S288C
Interactions: 102
UniProt ID: P09064

Gene Ontology (top 5):
GO:0001731 - formation of translation preinitiation complex
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005840 - ribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

478598

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

15

7

Small-scale

0.986

High

478604

SUI1
Eukaryotic translation initiation factor eIF-1

3

2

Small-scale

0.840

High

430742

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

2

1

High-throughput

0.802

High

478615

IF5
Eukaryotic translation initiation factor 5

12

9

Small-scale

0.760

High

478600

EI2BE
Translation initiation factor eIF2B subunit epsilon

12

5

Small-scale

0.758

High

478621

IF2P
Eukaryotic translation initiation factor 5B

2

4

Small-scale

0.754

High

478378

EI2BG
Translation initiation factor eIF2B subunit gamma

8

5

Small-scale

0.754

High

478583

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

8

6

Small-scale

0.747

High

478581

EI2BA
Translation initiation factor eIF2B subunit alpha

5

7

Small-scale

0.714

High

478601

EI2BB
Translation initiation factor eIF2B subunit beta

5

7

Small-scale

0.714

High

438358

EIF3B
Eukaryotic translation initiation factor 3 subunit B

4

3

Small-scale

0.683

High

478612

EIF3A
Eukaryotic translation initiation factor 3 subunit A

3

2

Small-scale

0.662

High

478577

EI2BD
Translation initiation factor eIF2B subunit delta

3

7

Small-scale

0.646

High

478599

EIF3C
Eukaryotic translation initiation factor 3 subunit C

3

3

Small-scale

0.642

High

478611

HEK2
Heterogeneous nuclear rnp K-like protein 2

2

1

High-throughput

0.621

High

478637

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.618

High

478584

IF5A1
Eukaryotic translation initiation factor 5A-1

2

0

Small-scale

0.559

High

478631

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

478636

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

478643

CD123
Translation initiation factor eIF2 assembly protein

2

2

Small-scale

0.521

High

478593

NSR1
Nuclear localization sequence-binding protein

1

2

High-throughput

0.515

High

478622

FKH1
Fork head protein homolog 1

1

0

High-throughput

0.513

High

441001

KAPA
cAMP-dependent protein kinase type 1

1

4

Small-scale

0.501

High

478568

IF2B
Eukaryotic translation initiation factor 2 subunit beta

1

3

Small-scale

0.501

High

478639

PKH1
Serine/threonine-protein kinase PKH1

1

4

Small-scale

0.501

High

478595

XPO1
Exportin-1

1

5

High-throughput

0.489

High

478582

GCN2
eIF-2-alpha kinase GCN2

1

0

Small-scale

0.480

High

149497

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

383240

RL28
Large ribosomal subunit protein uL15

1

1

High-throughput

0.479

High

409849

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

433355

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.479

High

434708

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

435679

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

436264

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.479

High

441616

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

454780

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.479

High

478569

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

478570

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.479

High

478571

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.479

High

478572

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.479

High

478573

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

478578

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

478580

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

478585

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

478586

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

478589

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

478590

RL5
Large ribosomal subunit protein uL18

1

2

High-throughput

0.479

High

478591

RL16A
Large ribosomal subunit protein uL13A

1

3

High-throughput

0.479

High

478592

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.479

High

478594

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

478596

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

478603

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.479

High

478605

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.479

High

478607

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

478608

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

478610

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

478616

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

478619

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.479

High

478620

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

478625

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

5

High-throughput

0.479

High

478629

RL26B
Large ribosomal subunit protein uL24B

1

2

High-throughput

0.479

High

478630

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

478633

GIS2
Zinc finger protein GIS2

1

2

High-throughput

0.479

High

478640

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

478647

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

383427

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

433940

RL33A
Large ribosomal subunit protein eL33A

1

0

High-throughput

0.458

High

478579

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

478606

URB1
Nucleolar pre-ribosomal-associated protein 1

1

0

Small-scale

0.458

High

478617

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

478627

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

478642

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

478648

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

478576

SCH9
Serine/threonine-protein kinase SCH9

1

4

Small-scale

0.457

High

392045

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

478574

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

478575

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

478587

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

478609

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

478638

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

478649

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.437

High

376174

RAS1
Ras-like protein 1

1

3

High-throughput

0.407

High

478602

PP12
Serine/threonine-protein phosphatase PP1-2

3

0

High-throughput

0.347

High

478632

IST1
Vacuolar protein sorting-associated protein IST1

2

0

High-throughput

0.307

High

478623

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

427079

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.249

Low

478588

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

478597

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

478613

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

478614

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

478624

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

478626

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

478628

GNP1
High-affinity glutamine permease

1

0

High-throughput

0.249

Low

478634

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

478641

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

478644

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

478645

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

478646

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

478650

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

478618

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.232

Low

478635

H3
Histone H3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025