Protein: HCFC1
Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]

Gene: HCFC1
Organism: Homo sapiens
Interactions: 229
UniProt ID: P51610

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000123 - histone acetyltransferase complex
GO:0003682 - chromatin binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

848326

HCFC2
Host cell factor 2

4

15

Small-scale

0.892

High

848174

HCFC1
Host cell factor 1

2

16

Small-scale

0.767

High

848263

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

16

5

Small-scale

0.764

High

216692

CREB3
Cyclic AMP-responsive element-binding protein 3

11

2

Small-scale

0.760

High

848312

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

9

7

Small-scale

0.753

High

848181

WDR5
WD repeat-containing protein 5

7

5

Small-scale

0.744

High

174733

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

6

2

Small-scale

0.742

High

848222

RBBP5
Retinoblastoma-binding protein 5

6

8

Small-scale

0.724

High

346273

MYC
Myc proto-oncogene protein

6

9

Small-scale

0.721

High

165649

SET1A
Histone-lysine N-methyltransferase SETD1A

5

20

Small-scale

0.709

High

848298

ZHANG
CREB/ATF bZIP transcription factor

5

0

Small-scale

0.691

High

848270

THA11
THAP domain-containing protein 11

5

0

Small-scale

0.690

High

848249

ASXL1
Polycomb group protein ASXL1

4

2

Small-scale

0.686

High

848275

SIN3A
Paired amphipathic helix protein Sin3a

3

3

Small-scale

0.677

High

848196

FOXK2
Forkhead box protein K2

3

6

Small-scale

0.674

High

848199

KMT2A
Histone-lysine N-methyltransferase 2A

3

20

Small-scale

0.671

High

848289

THAP2
THAP domain-containing protein 2

3

8

High-throughput

0.667

High

848307

CXXC1
CXXC-type zinc finger protein 1

3

13

Small-scale

0.662

High

848242

ASXL2
Putative Polycomb group protein ASXL2

3

7

Small-scale

0.656

High

848294

KAT8
Histone acetyltransferase KAT8

3

1

Small-scale

0.656

High

540810

PO2F1
POU domain, class 2, transcription factor 1

3

1

Small-scale

0.650

High

848218

NF2L1
Endoplasmic reticulum membrane sensor NFE2L1

2

7

Small-scale

0.640

High

848262

THAP3
THAP domain-containing protein 3

2

8

Small-scale

0.639

High

848304

HPIP
Host cell factor C1 regulator 1

3

0

Small-scale

0.638

High

848301

THAP1
THAP domain-containing protein 1

2

8

Small-scale

0.637

High

435017

SP1
Transcription factor Sp1

2

4

Small-scale

0.636

High

122574

MEN1
Menin

3

1

Small-scale

0.633

High

848251

SLX4
Structure-specific endonuclease subunit SLX4

3

6

High-throughput

0.633

High

536495

IRF2
Interferon regulatory factor 2

2

4

High-throughput

0.628

High

848324

NF2L3
Nuclear factor erythroid 2-related factor 3

2

5

High-throughput

0.628

High

632656

TYY1
Transcriptional repressor protein YY1

2

1

Small-scale

0.624

High

848281

DIDO1
Death-inducer obliterator 1

2

14

High-throughput

0.621

High

848195

E2F1
Transcription factor E2F1

2

3

Small-scale

0.620

High

779052

CCNF
Cyclin-F

2

3

High-throughput

0.612

High

469972

H2AZ
Histone H2A.Z

2

4

High-throughput

0.611

High

848213

CUL3
Cullin-3

2

20

High-throughput

0.611

High

848219

NCOA6
Nuclear receptor coactivator 6

2

7

Small-scale

0.611

High

848309

KANL3
KAT8 regulatory NSL complex subunit 3

2

1

High-throughput

0.611

High

848267

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

2

0

High-throughput

0.602

High

848273

ZN597
Zinc finger protein 597

2

2

High-throughput

0.601

High

848284

DPY30
Protein dpy-30 homolog

2

1

Small-scale

0.594

High

848317

KMT2B
Histone-lysine N-methyltransferase 2B

2

20

Small-scale

0.594

High

848204

ZBT17
Zinc finger and BTB domain-containing protein 17

1

1

Small-scale

0.586

High

226908

PRKN
E3 ubiquitin-protein ligase parkin

2

12

High-throughput

0.584

High

244141

BRD4
Bromodomain-containing protein 4

2

6

High-throughput

0.584

High

386346

P53
Cellular tumor antigen p53

2

1

High-throughput

0.584

High

487248

ANDR
Androgen receptor

2

8

High-throughput

0.584

High

503713

HSP7C
Heat shock cognate 71 kDa protein

2

4

Small-scale

0.584

High

552274

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

607796

USF1
Upstream stimulatory factor 1

2

8

Small-scale

0.584

High

808410

YAP1
Transcriptional coactivator YAP1

2

5

Small-scale

0.584

High

848236

WDR82
WD repeat-containing protein 82

2

12

Small-scale

0.584

High

848217

FHL2
Four and a half LIM domains protein 2

1

3

Small-scale

0.573

High

848182

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

Small-scale

0.561

High

848247

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.561

High

848200

GABPA
GA-binding protein alpha chain

1

5

Small-scale

0.560

High

650715

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

720012

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

848291

ZN335
Zinc finger protein 335

1

1

Small-scale

0.554

High

848318

PHF8
Histone lysine demethylase PHF8

1

8

Small-scale

0.554

High

135230

E2F3
Transcription factor E2F3

1

3

Small-scale

0.552

High

848226

E2F4
Transcription factor E2F4

1

3

Small-scale

0.552

High

848300

ASF1B
Histone chaperone ASF1B

1

1

Small-scale

0.552

High

848227

PDCD2
Programmed cell death protein 2

1

0

Small-scale

0.549

High

505196

EGR2
E3 SUMO-protein ligase EGR2

1

2

Small-scale

0.541

High

848280

THAP7
THAP domain-containing protein 7

1

8

High-throughput

0.541

High

296436

ACL6B
Actin-like protein 6B

1

3

High-throughput

0.536

High

446544

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.536

High

538868

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

2

Small-scale

0.536

High

687044

FOXN2
Forkhead box protein N2

1

3

High-throughput

0.536

High

801034

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.536

High

804178

NOTC1
Neurogenic locus notch homolog protein 1

1

2

High-throughput

0.536

High

848175

NEK4
Serine/threonine-protein kinase Nek4

1

4

High-throughput

0.536

High

848188

CSK21
Casein kinase II subunit alpha

1

10

High-throughput

0.536

High

848191

CBX1
Chromobox protein homolog 1

1

3

High-throughput

0.536

High

848202

SSRP1
FACT complex subunit SSRP1

1

7

High-throughput

0.536

High

848203

RBBP4
Histone-binding protein RBBP4

1

7

Small-scale

0.536

High

848211

HDAC1
Histone deacetylase 1

1

2

Small-scale

0.536

High

848228

RBBP7
Histone-binding protein RBBP7

1

8

Small-scale

0.536

High

848229

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

6

High-throughput

0.536

High

848231

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

848248

NUDC3
NudC domain-containing protein 3

1

14

High-throughput

0.536

High

848265

HDAC2
Histone deacetylase 2

1

2

Small-scale

0.536

High

848276

MPP8
M-phase phosphoprotein 8

1

5

High-throughput

0.536

High

848325

TNPO3
Transportin-3

1

5

High-throughput

0.536

High

831120

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.527

High

848201

GABP1
GA-binding protein subunit beta-1

1

3

Small-scale

0.526

High

257758

SIN3B
Paired amphipathic helix protein Sin3b

1

3

Small-scale

0.515

High

391605

H2A1B
Histone H2A type 1-B/E

1

3

High-throughput

0.515

High

501019

IRF1
Interferon regulatory factor 1

1

4

High-throughput

0.515

High

255078

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

448576

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

508404

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

564840

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

848212

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.513

High

848220

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

848261

ARRD2
Arrestin domain-containing protein 2

1

0

High-throughput

0.513

High

848272

SENP5
Sentrin-specific protease 5

1

0

High-throughput

0.513

High

848293

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

0

Small-scale

0.513

High

848323

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.513

High

848260

THAP6
THAP domain-containing protein 6

1

8

High-throughput

0.489

High

848180

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

68278

P20L1
PHD finger protein 20-like protein 1

1

5

High-throughput

0.479

High

125261

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

152616

KMT2D
Histone-lysine N-methyltransferase 2D

1

20

High-throughput

0.479

High

183087

KDM6A
Lysine-specific demethylase 6A

1

4

High-throughput

0.479

High

195825

TET3
Methylcytosine dioxygenase TET3

1

9

Small-scale

0.479

High

206815

FOXO3
Forkhead box protein O3

1

6

Small-scale

0.479

High

211142

BUB3
Mitotic checkpoint protein BUB3

1

8

High-throughput

0.479

High

213507

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

10

Small-scale

0.479

High

232817

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.479

High

261445

NCOR1
Nuclear receptor corepressor 1

1

9

High-throughput

0.479

High

267963

EED
Polycomb protein EED

1

10

High-throughput

0.479

High

294552

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

338149

EGFR
Epidermal growth factor receptor

1

3

Small-scale

0.479

High

359774

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

373910

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

379144

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.479

High

384518

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

431669

HS90A
Heat shock protein HSP 90-alpha

1

10

Small-scale

0.479

High

499636

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

521816

CADH1
Cadherin-1

1

3

High-throughput

0.479

High

525298

NR2C1
Nuclear receptor subfamily 2 group C member 1

1

3

Small-scale

0.479

High

555361

H2AX
Histone H2AX

1

4

High-throughput

0.479

High

569419

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

624568

CCNE1
G1/S-specific cyclin-E1

1

1

Small-scale

0.479

High

625250

CDK2
Cyclin-dependent kinase 2

1

4

High-throughput

0.479

High

660103

RBL1
Retinoblastoma-like protein 1

1

1

Small-scale

0.479

High

668531

PML
Protein PML

1

8

High-throughput

0.479

High

673375

MPIP1
M-phase inducer phosphatase 1

1

1

Small-scale

0.479

High

714143

HSP74
Heat shock 70 kDa protein 4

1

6

Small-scale

0.479

High

742138

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

749249

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

823725

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

848177

ATN1
Atrophin-1

1

12

High-throughput

0.479

High

848178

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

6

High-throughput

0.479

High

848183

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

848184

H4
Histone H4

1

3

High-throughput

0.479

High

848185

RSMN
Small nuclear ribonucleoprotein-associated protein N

1

2

Small-scale

0.479

High

848187

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

848189

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

848190

RED1
Double-stranded RNA-specific editase 1

1

5

High-throughput

0.479

High

848192

H33
Histone H3.3

1

1

High-throughput

0.479

High

848193

FOXK1
Forkhead box protein K1

1

6

Small-scale

0.479

High

848198

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.479

High

848205

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

6

High-throughput

0.479

High

848206

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

8

High-throughput

0.479

High

848207

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

848208

TIF1B
Transcription intermediary factor 1-beta

1

8

High-throughput

0.479

High

848209

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

5

High-throughput

0.479

High

848210

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

848215

KLF5
Krueppel-like factor 5

1

3

Small-scale

0.479

High

848216

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.479

High

848221

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

848223

SMAD2
Mothers against decapentaplegic homolog 2

1

1

Small-scale

0.479

High

848224

SMAD1
Mothers against decapentaplegic homolog 1

1

1

Small-scale

0.479

High

848225

EZH2
Histone-lysine N-methyltransferase EZH2

1

15

High-throughput

0.479

High

848230

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

High-throughput

0.479

High

848233

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

848235

TET2
Methylcytosine dioxygenase TET2

1

2

Small-scale

0.479

High

848237

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

848239

PAXI1
PAX-interacting protein 1

1

6

High-throughput

0.479

High

848243

KANL1
KAT8 regulatory NSL complex subunit 1

1

1

High-throughput

0.479

High

848244

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

848245

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

848250

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

848252

ZZZ3
ZZ-type zinc finger-containing protein 3

1

3

High-throughput

0.479

High

848253

KMT2E
Inactive histone-lysine N-methyltransferase 2E

1

11

Small-scale

0.479

High

848255

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

848256

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.479

High

848258

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

12

High-throughput

0.479

High

848259

NUP43
Nucleoporin Nup43

1

10

High-throughput

0.479

High

848268

MBD6
Methyl-CpG-binding domain protein 6

1

7

High-throughput

0.479

High

848269

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

4

Small-scale

0.479

High

848271

MCRS1
Microspherule protein 1

1

1

High-throughput

0.479

High

848274

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

848277

TBX5
T-box transcription factor TBX5

1

1

High-throughput

0.479

High

848279

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

7

High-throughput

0.479

High

848282

PHF20
PHD finger protein 20

1

11

High-throughput

0.479

High

848283

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.479

High

848286

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

6

High-throughput

0.479

High

848287

ASXL3
Putative Polycomb group protein ASXL3

1

4

Small-scale

0.479

High

848288

WWTR1
WW domain-containing transcription regulator protein 1

1

5

High-throughput

0.479

High

848290

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

848292

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

848295

CSR2B
Cysteine-rich protein 2-binding protein

1

5

High-throughput

0.479

High

848296

KANL2
KAT8 regulatory NSL complex subunit 2

1

1

High-throughput

0.479

High

848297

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

848299

MBIP1
MAP3K12-binding inhibitory protein 1

1

2

High-throughput

0.479

High

848303

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

848308

MBD5
Methyl-CpG-binding domain protein 5

1

1

High-throughput

0.479

High

848310

RERE
Arginine-glutamic acid dipeptide repeats protein

1

11

High-throughput

0.479

High

848311

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

1

Small-scale

0.479

High

848313

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

848314

FBW1B
F-box/WD repeat-containing protein 11

1

9

High-throughput

0.479

High

848315

ZN608
Zinc finger protein 608

1

4

High-throughput

0.479

High

848316

YETS2
YEATS domain-containing protein 2

1

6

High-throughput

0.479

High

848319

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.479

High

848320

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

848321

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

848322

FBW1A
F-box/WD repeat-containing protein 1A

1

9

High-throughput

0.479

High

848238

NYAP1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

1

7

High-throughput

0.470

High

848240

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

5

High-throughput

0.470

High

848266

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

0

Small-scale

0.460

High

148556

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

303031

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

523611

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

848176

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

0

High-throughput

0.458

High

848179

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.458

High

848186

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

848241

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

848254

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

848257

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

848278

ASCL2
Achaete-scute homolog 2

1

0

Small-scale

0.458

High

848305

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

848306

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

848214

FHL3
Four and a half LIM domains protein 3

1

3

Small-scale

0.457

High

848246

PRGC2
Peroxisome proliferator-activated receptor gamma coactivator 1-beta

1

1

High-throughput

0.457

High

401669

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

848197

TAGL
Transgelin

1

1

High-throughput

0.445

High

848234

PKHA7
Pleckstrin homology domain-containing family A member 7

1

8

High-throughput

0.445

High

848264

ESR2
Estrogen receptor beta

1

8

High-throughput

0.445

High

848285

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

848194

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.442

High

848232

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.437

High

848302

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

20

High-throughput

0.437

High

48637

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

326915

DDAH2
Putative hydrolase DDAH2

3

0

High-throughput

0.347

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024