Protein: PSA
Puromycin-sensitive aminopeptidase (PSA) (EC 3.4.11.14) (Cytosol alanyl aminopeptidase) (AAP-S)

Gene: PSA, NPEPPS
Organism: Homo sapiens
Interactions: 125
UniProt ID: P55786

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0004177 - aminopeptidase activity
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

528840

CFTR
Cystic fibrosis transmembrane conductance regulator

3

2

High-throughput

0.650

High

878529

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

4

High-throughput

0.628

High

878522

CUL3
Cullin-3

2

1

High-throughput

0.611

High

496660

TAU
Microtubule-associated protein tau

2

3

Small-scale

0.585

High

226989

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

503765

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.584

High

808434

YAP1
Transcriptional coactivator YAP1

2

1

High-throughput

0.584

High

878513

CAV1
Caveolin-1

2

2

High-throughput

0.571

High

549883

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

1

High-throughput

0.536

High

702870

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.536

High

878510

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

1

High-throughput

0.536

High

878514

KLC1
Kinesin light chain 1

1

1

High-throughput

0.536

High

878517

KIF5A
Kinesin heavy chain isoform 5A

1

1

High-throughput

0.536

High

878531

LRC8B
Volume-regulated anion channel subunit LRRC8B

1

4

High-throughput

0.536

High

878534

LRC8D
Volume-regulated anion channel subunit LRRC8D

1

4

High-throughput

0.536

High

878537

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

4

High-throughput

0.536

High

878548

LRC8C
Volume-regulated anion channel subunit LRRC8C

1

4

High-throughput

0.536

High

878581

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

878515

DMWD
Dystrophia myotonica WD repeat-containing protein

1

1

High-throughput

0.515

High

307889

SNX4
Sorting nexin-4

1

0

High-throughput

0.513

High

878519

CLN3
Battenin

1

0

High-throughput

0.513

High

878526

MYLK
Myosin light chain kinase, smooth muscle

1

0

High-throughput

0.513

High

878536

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

878538

TCAL8
Transcription elongation factor A protein-like 8

1

0

High-throughput

0.513

High

878546

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

878561

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

878569

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

329547

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.493

High

779103

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

878504

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.493

High

878512

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.493

High

878525

P2RY6
P2Y purinoceptor 6

1

7

High-throughput

0.489

High

344958

CYTN
Cystatin-SN

1

1

Small-scale

0.479

High

346341

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

354385

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

3

High-throughput

0.479

High

373949

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

438726

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.479

High

552352

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

569471

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

572608

VGFR1
Vascular endothelial growth factor receptor 1

1

2

High-throughput

0.479

High

577856

RL17
Large ribosomal subunit protein uL22

1

2

High-throughput

0.479

High

650795

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

655288

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

2

High-throughput

0.479

High

713778

RYK
Tyrosine-protein kinase RYK

1

4

Small-scale

0.479

High

718660

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

749290

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

821958

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.479

High

827885

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

835613

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

849969

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.479

High

874732

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

878505

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.479

High

878507

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

878509

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

878511

VIGLN
Vigilin

1

1

High-throughput

0.479

High

878523

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

4

High-throughput

0.479

High

878524

CUL7
Cullin-7

1

1

High-throughput

0.479

High

878530

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

878532

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

878539

CDK20
Cyclin-dependent kinase 20

1

1

Small-scale

0.479

High

878542

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

878550

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

878551

TP4A1
Protein tyrosine phosphatase type IVA 1

1

1

High-throughput

0.479

High

878557

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

878558

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

878559

DUS23
Dual specificity protein phosphatase 23

1

1

High-throughput

0.479

High

878560

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

878562

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

1

High-throughput

0.479

High

878565

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

878570

RHOF
Rho-related GTP-binding protein RhoF

1

11

High-throughput

0.479

High

878572

FBX6
F-box only protein 6

1

6

High-throughput

0.479

High

878575

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

878577

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.479

High

878580

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

322382

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

326537

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

351735

SOMA
Somatotropin

1

0

High-throughput

0.458

High

386397

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

554812

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

617491

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

625273

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

673047

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.458

High

817838

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

870714

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

878506

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

878508

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

878516

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

878518

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

878520

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

878521

MTMR1
Myotubularin-related protein 1

1

0

High-throughput

0.458

High

878527

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

878535

CMKMT
Calmodulin-lysine N-methyltransferase

1

0

High-throughput

0.458

High

878540

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

878543

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

878545

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

878547

FBX25
F-box only protein 25

1

0

High-throughput

0.458

High

878549

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

878552

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

878553

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

878555

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

878563

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

878564

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

878566

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

878567

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

878571

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

878573

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

878574

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

878576

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.458

High

878578

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

878579

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

401712

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

587483

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.445

High

384571

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

720087

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

738183

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

1

High-throughput

0.437

High

878556

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.437

High

878528

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

831149

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

878544

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.407

High

878554

FAF2
FAS-associated factor 2

2

0

High-throughput

0.318

High

259433

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.279

Low

878533

PAQR9
Membrane progestin receptor epsilon

1

0

Small-scale

0.249

Low

878541

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

878568

F204A
Protein FAM204A

1

0

High-throughput

0.249

Low

993

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024