Protein: PHS
Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD)

Gene: PHS, PCBD1
Organism: Homo sapiens
Interactions: 113
UniProt ID: P61457

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0004505 - phenylalanine 4-monooxygenase activity
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006729 - tetrahydrobiopterin biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

961591

PHS
Pterin-4-alpha-carbinolamine dehydratase

7

5

Small-scale

0.968

High

961638

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

2

5

High-throughput

0.817

High

775818

HNF1B
Hepatocyte nuclear factor 1-beta

6

6

High-throughput

0.737

High

900262

FXR2
RNA-binding protein FXR2

5

0

High-throughput

0.687

High

635177

HNF1A
Hepatocyte nuclear factor 1-alpha

5

6

Small-scale

0.659

High

961628

NTAQ1
Protein N-terminal glutamine amidohydrolase

3

0

High-throughput

0.639

High

140209

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

680832

PSA1
Proteasome subunit alpha type-1

2

0

High-throughput

0.580

High

961646

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

421845

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.578

High

961652

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

High-throughput

0.578

High

961606

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

1

High-throughput

0.553

High

961658

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

1

Small-scale

0.552

High

165029

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

1

High-throughput

0.541

High

626146

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

High-throughput

0.541

High

664374

ZBT25
Zinc finger and BTB domain-containing protein 25

1

1

High-throughput

0.541

High

961642

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

1

High-throughput

0.541

High

961645

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.541

High

961592

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.537

High

507142

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.536

High

961599

CUL1
Cullin-1

1

4

High-throughput

0.536

High

961600

CUL3
Cullin-3

1

4

High-throughput

0.536

High

961601

CUL4A
Cullin-4A

1

4

High-throughput

0.536

High

961602

CUL4B
Cullin-4B

1

4

High-throughput

0.536

High

961607

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.536

High

961613

PHF6
PHD finger protein 6

1

1

High-throughput

0.536

High

961614

ZZZ3
ZZ-type zinc finger-containing protein 3

1

1

High-throughput

0.536

High

961621

CUL5
Cullin-5

1

4

High-throughput

0.536

High

130422

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.518

High

159590

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.518

High

282230

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.518

High

833909

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

High-throughput

0.518

High

961595

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

High-throughput

0.518

High

961597

RBL2
Retinoblastoma-like protein 2

1

0

High-throughput

0.518

High

961608

M18BP
Mis18-binding protein 1

1

0

High-throughput

0.518

High

961611

NUD18
8-oxo-dGDP phosphatase NUDT18

1

0

High-throughput

0.518

High

961612

MYCPP
C-myc promoter-binding protein

1

0

High-throughput

0.518

High

961624

SCMH1
Polycomb protein SCMH1

1

0

High-throughput

0.518

High

961626

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.518

High

961634

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.518

High

961635

TRIM5
Tripartite motif-containing protein 5

1

0

High-throughput

0.518

High

961637

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

0

High-throughput

0.518

High

961649

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

0

High-throughput

0.518

High

961655

TIM
Protein timeless homolog

1

0

High-throughput

0.518

High

961661

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.518

High

58713

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

0

High-throughput

0.513

High

283454

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.513

High

961594

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.513

High

961616

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.513

High

961620

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

961625

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

961640

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.513

High

961644

GPCP1
Glycerophosphocholine phosphodiesterase GPCPD1

1

0

High-throughput

0.513

High

961647

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.513

High

961654

YETS2
YEATS domain-containing protein 2

1

0

High-throughput

0.513

High

158986

ZN195
Zinc finger protein 195

1

1

High-throughput

0.494

High

171858

ZN263
Zinc finger protein 263

1

3

High-throughput

0.494

High

326407

ZN202
Zinc finger protein 202

1

2

High-throughput

0.494

High

961643

HES4
Transcription factor HES-4

1

1

High-throughput

0.494

High

683423

IKBA
NF-kappa-B inhibitor alpha

1

1

High-throughput

0.479

High

749886

KINH
Kinesin-1 heavy chain

1

1

High-throughput

0.479

High

861101

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

895906

F10A1
Hsc70-interacting protein

1

2

High-throughput

0.479

High

903116

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

1

High-throughput

0.479

High

961598

KIF5A
Kinesin heavy chain isoform 5A

1

1

High-throughput

0.479

High

361033

PH4H
Phenylalanine-4-hydroxylase

1

0

Small-scale

0.460

High

961603

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

Small-scale

0.460

High

961632

CK5P2
CDK5 regulatory subunit-associated protein 2

1

0

High-throughput

0.460

High

221846

CHM2A
Charged multivesicular body protein 2a

1

0

High-throughput

0.458

High

400586

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

536882

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

538930

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

620243

NUCL
Nucleolin

1

0

High-throughput

0.458

High

673840

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

961593

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.458

High

961604

MAP7
Ensconsin

1

0

High-throughput

0.458

High

961609

CPLX2
Complexin-2

1

0

High-throughput

0.458

High

961610

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

961623

THOC1
THO complex subunit 1

1

0

High-throughput

0.458

High

961630

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

961651

SAE2
SUMO-activating enzyme subunit 2

1

0

High-throughput

0.458

High

961653

MYT1L
Myelin transcription factor 1-like protein

1

0

High-throughput

0.458

High

961660

PRC2C
Protein PRRC2C

1

0

High-throughput

0.458

High

327894

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

961639

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

505705

ZN688
Zinc finger protein 688

1

2

High-throughput

0.439

High

961619

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

404754

PRIO
Major prion protein

1

0

High-throughput

0.426

High

3531

A0A0S2Z5X4
Zinc finger protein 688 isoform 4

1

1

High-throughput

0.417

High

961641

GORS2
Golgi reassembly-stacking protein 2

5

0

High-throughput

0.374

High

961617

LNX1
E3 ubiquitin-protein ligase LNX

4

0

High-throughput

0.368

High

961596

TFF3
Trefoil factor 3

3

0

High-throughput

0.352

High

600225

ZNF23
Zinc finger protein 23

1

0

High-throughput

0.282

High

961605

SWAHC
Ankyrin repeat domain-containing protein SOWAHC

1

0

High-throughput

0.282

High

961615

ZN567
Zinc finger protein 567

1

0

High-throughput

0.282

High

961631

ZN714
Zinc finger protein 714

1

0

High-throughput

0.282

High

961636

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.282

High

961656

DIP2C
Disco-interacting protein 2 homolog C

1

0

High-throughput

0.282

High

961657

KLF13
Krueppel-like factor 13

1

0

High-throughput

0.282

High

961659

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.282

High

345168

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

961618

DNJB3
DnaJ homolog subfamily B member 3

1

0

High-throughput

0.279

Low

961622

C102A
Coiled-coil domain-containing protein 102A

1

0

High-throughput

0.279

Low

105688

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

565592

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.249

Low

639116

SYT1
Synaptotagmin-1

1

0

High-throughput

0.249

Low

643228

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.249

Low

961627

PGCB
Brevican core protein

1

0

High-throughput

0.249

Low

961629

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.249

Low

961633

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

961648

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

0

High-throughput

0.249

Low

961650

F135A
Protein FAM135A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025