Protein: E2AK4
eIF-2-alpha kinase GCN2 (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 4) (GCN2-like protein)

Gene: E2AK4, EIF2AK4
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q9P2K8

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000077 - DNA damage checkpoint signaling
GO:0002230 - positive regulation of defense response to virus by host
GO:0002250 - adaptive immune response
GO:0002286 - T cell activation involved in immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

259155

DNJA2
DnaJ homolog subfamily A member 2

2

3

High-throughput

0.776

High

1252607

DEFI8
Differentially expressed in FDCP 8 homolog

2

3

High-throughput

0.726

High

786904

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

5

7

High-throughput

0.716

High

968016

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

4

7

High-throughput

0.699

High

295650

CIB2
Calcium and integrin-binding family member 2

1

20

High-throughput

0.691

High

1417894

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.691

High

732728

ARRB2
Beta-arrestin-2

2

4

Small-scale

0.639

High

1454696

OCTC
Peroxisomal carnitine O-octanoyltransferase

3

0

High-throughput

0.638

High

179745

MDM4
Protein Mdm4

2

3

High-throughput

0.628

High

610494

PRS6A
26S proteasome regulatory subunit 6A

2

4

High-throughput

0.628

High

712295

TKT
Transketolase

2

1

High-throughput

0.628

High

401627

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

15

High-throughput

0.618

High

620628

NUCL
Nucleolin

1

2

High-throughput

0.618

High

831571

CCNF
Cyclin-F

1

4

High-throughput

0.618

High

1090578

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

Small-scale

0.618

High

1140976

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.618

High

1158583

CDC37
Hsp90 co-chaperone Cdc37

1

9

High-throughput

0.618

High

1245581

Q6PK50
HSP90AB1 protein

1

20

High-throughput

0.618

High

1255906

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

1434112

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.618

High

1454699

CRYL1
Lambda-crystallin homolog

2

0

High-throughput

0.602

High

391510

FRIL
Ferritin light chain

2

1

High-throughput

0.601

High

1033281

EWS
RNA-binding protein EWS

1

1

High-throughput

0.590

High

1110581

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

13

High-throughput

0.575

High

1211462

CF141
Uncharacterized protein C6orf141

2

1

High-throughput

0.574

High

882575

ARRB1
Beta-arrestin-1

1

4

Small-scale

0.561

High

1250208

LRC31
Leucine-rich repeat-containing protein 31

1

4

High-throughput

0.553

High

549706

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.536

High

606048

CAN2
Calpain-2 catalytic subunit

1

6

High-throughput

0.536

High

682638

S100P
Protein S100-P

1

6

High-throughput

0.536

High

842006

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

3

High-throughput

0.536

High

848086

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

2

High-throughput

0.536

High

848739

MAGA9
Melanoma-associated antigen 9

1

6

High-throughput

0.536

High

967183

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

1

High-throughput

0.536

High

1052918

HME1
Homeobox protein engrailed-1

1

3

High-throughput

0.536

High

1093072

CDC16
Cell division cycle protein 16 homolog

1

6

High-throughput

0.536

High

1215993

KAD9
Adenylate kinase 9

1

3

High-throughput

0.536

High

1383881

EFMT3
EEF1A lysine methyltransferase 3

1

9

High-throughput

0.536

High

1420248

UBXN6
UBX domain-containing protein 6

1

3

High-throughput

0.536

High

1454579

KLH14
Kelch-like protein 14

1

6

High-throughput

0.536

High

431928

ITB1
Integrin beta-1

1

2

High-throughput

0.515

High

642595

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

846512

MATR3
Matrin-3

1

0

High-throughput

0.513

High

1064602

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.513

High

1243742

PGM2L
Glucose 1,6-bisphosphate synthase

1

0

High-throughput

0.493

High

1323930

KLH34
Kelch-like protein 34

1

7

High-throughput

0.489

High

131523

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

1

High-throughput

0.479

High

177071

CE290
Centrosomal protein of 290 kDa

1

4

High-throughput

0.479

High

347383

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.479

High

607180

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

731662

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

837885

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

946210

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.479

High

1024903

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1098155

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

1106731

SMAD4
Mothers against decapentaplegic homolog 4

1

3

High-throughput

0.479

High

1153606

MLF2
Myeloid leukemia factor 2

1

1

High-throughput

0.479

High

1198799

Q53FC7
Heat shock 70 kDa protein 6

1

8

High-throughput

0.479

High

1276900

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1308604

NUDC3
NudC domain-containing protein 3

1

2

High-throughput

0.479

High

1314717

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.479

High

1336865

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

Small-scale

0.479

High

1340827

COP1
E3 ubiquitin-protein ligase COP1

1

5

High-throughput

0.479

High

1365784

GCN1
Stalled ribosome sensor GCN1

1

6

Small-scale

0.479

High

1380220

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1384544

Q96BE0
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.479

High

1400043

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

6

Small-scale

0.479

High

1413501

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.479

High

1417762

EIF2A
Eukaryotic translation initiation factor 2A

1

5

Small-scale

0.479

High

1437964

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

1454694

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1454695

XPO7
Exportin-7

1

7

High-throughput

0.479

High

1338412

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

58960

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

1227616

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.445

High

1428254

TGIF2
Homeobox protein TGIF2

1

2

High-throughput

0.445

High

76583

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

1

High-throughput

0.437

High

64912

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.426

High

1398234

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.426

High

1454123

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

4

High-throughput

0.407

High

1454698

PLAK2
PALM2-AKAP2 fusion protein

2

0

High-throughput

0.288

High

1454697

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

1454700

TMA7
Translation machinery-associated protein 7

1

0

High-throughput

0.249

Low

505297

F153B
Protein FAM153B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025