Protein: 5NTD
5'-nucleotidase (5'-NT) (EC 3.1.3.35) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.91) (EC 3.1.3.99) (5'-deoxynucleotidase) (Ecto-5'-nucleotidase) (IMP-specific 5'-nucleotidase) (Thymidylate 5'-phosphatase) (CD antigen CD73)

Gene: 5NTD, NT5E
Organism: Homo sapiens
Interactions: 87
UniProt ID: P21589

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0002953 - 5'-deoxynucleotidase activity
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

639364

RAB9A
Ras-related protein Rab-9A

3

1

High-throughput

0.861

High

639372

RHOG
Rho-related GTP-binding protein RhoG

3

0

High-throughput

0.816

High

639385

DAAF5
Dynein axonemal assembly factor 5

3

0

High-throughput

0.816

High

639388

RPTOR
Regulatory-associated protein of mTOR

2

0

High-throughput

0.748

High

639415

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

4

3

Small-scale

0.694

High

178717

SCAM1
Secretory carrier-associated membrane protein 1

3

1

High-throughput

0.667

High

639353

COT2
COUP transcription factor 2

3

1

High-throughput

0.667

High

639358

MOT8
Monocarboxylate transporter 8

3

1

High-throughput

0.667

High

639359

ARL2
ADP-ribosylation factor-like protein 2

3

1

High-throughput

0.667

High

639361

MTOR
Serine/threonine-protein kinase mTOR

3

1

High-throughput

0.667

High

639412

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

3

3

High-throughput

0.667

High

639420

SAR1B
Small COPII coat GTPase SAR1B

3

2

High-throughput

0.667

High

603831

CXA1
Gap junction alpha-1 protein

3

0

High-throughput

0.638

High

639362

SC6A8
Sodium- and chloride-dependent creatine transporter 1

3

0

High-throughput

0.638

High

639366

CTR2
Cationic amino acid transporter 2

3

0

High-throughput

0.638

High

639371

ARF5
ADP-ribosylation factor 5

3

0

High-throughput

0.638

High

639379

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

3

0

High-throughput

0.638

High

639381

STEA3
Metalloreductase STEAP3

3

0

High-throughput

0.638

High

639392

CTL1
Choline transporter-like protein 1

3

0

High-throughput

0.638

High

639397

PAQR1
Adiponectin receptor protein 1

3

0

High-throughput

0.638

High

639414

VANG2
Vang-like protein 2

3

0

High-throughput

0.638

High

639419

FLVC1
Choline/ethanolamine transporter FLVCR1

3

0

High-throughput

0.638

High

639421

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

3

High-throughput

0.628

High

639352

5NTD
5'-nucleotidase

1

0

Small-scale

0.614

High

639398

ARL8A
ADP-ribosylation factor-like protein 8A

2

1

High-throughput

0.611

High

639391

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

2

High-throughput

0.606

High

639416

RNF24
RING finger protein 24

2

2

High-throughput

0.606

High

639368

CXCR4
C-X-C chemokine receptor type 4

2

0

High-throughput

0.602

High

639369

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.586

High

639399

S47A1
Multidrug and toxin extrusion protein 1

2

0

High-throughput

0.585

High

639403

S26A6
Solute carrier family 26 member 6

2

0

High-throughput

0.585

High

395491

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

165529

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.536

High

164525

TNPO2
Transportin-2

1

0

High-throughput

0.517

High

639354

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

639377

I13R2
Interleukin-13 receptor subunit alpha-2

1

0

High-throughput

0.513

High

639382

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.513

High

639387

TM192
Transmembrane protein 192

1

0

High-throughput

0.513

High

639390

CAMKV
CaM kinase-like vesicle-associated protein

1

0

High-throughput

0.513

High

639396

T106A
Transmembrane protein 106A

1

0

High-throughput

0.513

High

639404

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

323169

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.479

High

639376

ATR
Serine/threonine-protein kinase ATR

1

1

High-throughput

0.479

High

639393

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

639406

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

Small-scale

0.479

High

639417

RNF6
E3 ubiquitin-protein ligase RNF6

1

1

High-throughput

0.479

High

178608

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.458

High

247674

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

348969

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.458

High

371155

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

399935

CATA
Catalase

1

0

High-throughput

0.458

High

410613

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

High-throughput

0.458

High

417945

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

612862

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

639355

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

639357

RFC2
Replication factor C subunit 2

1

0

High-throughput

0.458

High

639360

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

639363

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

639373

CREM
cAMP-responsive element modulator

1

0

Small-scale

0.458

High

639378

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

639383

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

639384

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

0

High-throughput

0.458

High

639386

S41A1
Solute carrier family 41 member 1

1

0

High-throughput

0.458

High

639394

SC5A5
Sodium/iodide cotransporter

1

0

Small-scale

0.458

High

639405

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

639407

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

0

Small-scale

0.458

High

639408

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.458

High

639409

ANLN
Anillin

1

0

High-throughput

0.458

High

639410

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

639411

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

0

High-throughput

0.458

High

639418

PLAP
Phospholipase A-2-activating protein

1

0

High-throughput

0.458

High

639367

CD81
CD81 antigen

1

1

High-throughput

0.445

High

563190

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

639356

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

639375

DDR1
Epithelial discoidin domain-containing receptor 1

1

0

Small-scale

0.426

High

639400

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High

639402

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.426

High

639380

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

3

0

High-throughput

0.347

High

639395

GLMN
Glomulin

3

0

High-throughput

0.347

High

639401

CP2S1
Cytochrome P450 2S1

3

0

High-throughput

0.347

High

639413

XPO7
Exportin-7

3

0

High-throughput

0.347

High

639389

RDH13
Retinol dehydrogenase 13

2

0

High-throughput

0.318

High

639370

ARGI2
Arginase-2, mitochondrial

1

0

High-throughput

0.269

Low

639365

AFF1
AF4/FMR2 family member 1

1

0

Small-scale

0.251

Low

105331

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

639374

TNAP2
Tumor necrosis factor alpha-induced protein 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025