Protein: XPA
DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein)

Gene: XPA
Organism: Homo sapiens
Interactions: 86
UniProt ID: P23025

Gene Ontology (top 5):
GO:0000110 - nucleotide-excision repair factor 1 complex
GO:0000715 - nucleotide-excision repair, DNA damage recognition
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

434561

ERCC1
DNA excision repair protein ERCC-1

18

2

Small-scale

0.766

High

551955

RFA2
Replication protein A 32 kDa subunit

14

2

Small-scale

0.763

High

612459

XPA
DNA repair protein complementing XP-A cells

2

2

Small-scale

0.755

High

612461

RFA1
Replication protein A 70 kDa DNA-binding subunit

12

0

Small-scale

0.727

High

612490

XPF
DNA repair endonuclease XPF

4

2

Small-scale

0.696

High

319720

HERC2
E3 ubiquitin-protein ligase HERC2

3

1

Small-scale

0.681

High

612488

NUP43
Nucleoporin Nup43

3

1

High-throughput

0.667

High

536728

TRI27
Zinc finger protein RFP

3

0

High-throughput

0.646

High

612479

ATR
Serine/threonine-protein kinase ATR

2

2

Small-scale

0.624

High

574123

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

Small-scale

0.618

High

612472

PRKDC
DNA-dependent protein kinase catalytic subunit

2

2

Small-scale

0.602

High

612473

XPC
DNA repair protein complementing XP-C cells

2

1

Small-scale

0.595

High

612484

Z518A
Zinc finger protein 518A

2

0

High-throughput

0.585

High

161187

VP26C
Vacuolar protein sorting-associated protein 26C

2

0

High-throughput

0.580

High

169796

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.580

High

521330

SKIL
Ski-like protein

2

0

High-throughput

0.580

High

594446

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

612487

ZN655
Zinc finger protein 655

2

0

High-throughput

0.580

High

612500

ARI3A
AT-rich interactive domain-containing protein 3A

2

0

High-throughput

0.580

High

612505

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

612474

ERCC6
DNA excision repair protein ERCC-6

2

0

Small-scale

0.569

High

612489

DDB2
DNA damage-binding protein 2

1

1

Small-scale

0.561

High

612494

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.554

High

210983

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

1

High-throughput

0.541

High

612467

MLH1
DNA mismatch repair protein Mlh1

1

2

High-throughput

0.541

High

612471

PMS2
Mismatch repair endonuclease PMS2

1

2

High-throughput

0.541

High

612509

MLH3
DNA mismatch repair protein Mlh3

1

2

High-throughput

0.541

High

517053

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.537

High

612512

CE164
Centrosomal protein of 164 kDa

1

0

Small-scale

0.537

High

612470

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.536

High

612504

SYF1
Pre-mRNA-splicing factor SYF1

1

0

Small-scale

0.529

High

612476

RFA4
Replication protein A 30 kDa subunit

1

2

Small-scale

0.527

High

160382

AURKA
Aurora kinase A

1

0

High-throughput

0.518

High

414168

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.518

High

522779

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.518

High

612466

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.518

High

612481

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.518

High

612482

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

612492

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.518

High

612498

RHG07
Rho GTPase-activating protein 7

1

0

High-throughput

0.518

High

612510

MUTYH
Adenine DNA glycosylase

1

0

High-throughput

0.518

High

612485

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

125844

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

213710

ENSA
Alpha-endosulfine

1

0

High-throughput

0.513

High

241269

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

0

High-throughput

0.513

High

612465

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.513

High

612478

TOP3A
DNA topoisomerase 3-alpha

1

0

High-throughput

0.513

High

594165

MSH3
DNA mismatch repair protein Msh3

1

2

Small-scale

0.501

High

612468

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.501

High

612477

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.501

High

612486

RHOU
Rho-related GTP-binding protein RhoU

1

2

High-throughput

0.501

High

348512

RASN
GTPase NRas

1

1

High-throughput

0.494

High

559554

H12
Histone H1.2

1

0

High-throughput

0.493

High

267375

ECI2
Enoyl-CoA delta isomerase 2

1

2

High-throughput

0.489

High

612503

GPN1
GPN-loop GTPase 1

1

0

Small-scale

0.486

High

612469

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

612463

T2EB
Transcription initiation factor IIE subunit beta

1

0

Small-scale

0.480

High

612483

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.480

High

162409

XPO1
Exportin-1

1

1

High-throughput

0.479

High

312479

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

High-throughput

0.479

High

612460

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.479

High

612464

TF2H1
General transcription factor IIH subunit 1

1

1

Small-scale

0.479

High

612508

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

612502

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

High-throughput

0.460

High

243937

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

449539

HMGB1
High mobility group protein B1

1

0

Small-scale

0.458

High

548224

FOSL1
Fos-related antigen 1

1

0

Small-scale

0.458

High

569191

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

612475

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.458

High

179547

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

Small-scale

0.438

High

612506

RASF1
Ras association domain-containing protein 1

1

0

Small-scale

0.438

High

612497

SNX27
Sorting nexin-27

1

2

High-throughput

0.437

High

612501

NDEL1
Nuclear distribution protein nudE-like 1

3

0

High-throughput

0.352

High

166810

SNPH
Syntaphilin

2

0

High-throughput

0.316

High

612491

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.316

High

612507

TBCD7
TBC1 domain family member 7

2

0

High-throughput

0.316

High

612480

PGFRL
Platelet-derived growth factor receptor-like protein

1

0

High-throughput

0.282

High

234904

SNX3
Sorting nexin-3

1

0

High-throughput

0.279

Low

612462

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

612493

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.279

Low

612495

HMCES
Abasic site processing protein HMCES

1

0

High-throughput

0.279

Low

612496

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.279

Low

612499

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.279

Low

612511

KLH21
Kelch-like protein 21

1

0

High-throughput

0.279

Low

360617

SPTA1
Spectrin alpha chain, erythrocytic 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024