Protein: PPBI
Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)

Gene: PPBI, ALPI
Organism: Homo sapiens
Interactions: 75
UniProt ID: P09923

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002020 - protease binding
GO:0004035 - alkaline phosphatase activity
GO:0005576 - extracellular region
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

426042

PPB1
Alkaline phosphatase, placental type

2

4

High-throughput

0.811

High

488292

PPBN
Alkaline phosphatase, germ cell type

2

4

High-throughput

0.811

High

488325

NT2NA
Notch homolog 2 N-terminal-like protein A

2

4

High-throughput

0.628

High

488305

ARF5
ADP-ribosylation factor 5

2

0

High-throughput

0.602

High

488335

RB39B
Ras-related protein Rab-39B

2

0

High-throughput

0.602

High

488296

ARL2
ADP-ribosylation factor-like protein 2

2

1

High-throughput

0.574

High

488355

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.574

High

170473

RAB7L
Ras-related protein Rab-7L1

1

1

High-throughput

0.536

High

488301

RAB38
Ras-related protein Rab-38

1

1

High-throughput

0.536

High

488306

RHOG
Rho-related GTP-binding protein RhoG

1

4

High-throughput

0.536

High

488308

HYAL2
Hyaluronidase-2

1

1

High-throughput

0.536

High

488309

SEM3B
Semaphorin-3B

1

1

High-throughput

0.536

High

488323

NFXL1
NF-X1-type zinc finger protein NFXL1

1

1

High-throughput

0.536

High

488334

ARL8A
ADP-ribosylation factor-like protein 8A

1

2

High-throughput

0.536

High

488336

VMP1
Vacuole membrane protein 1

1

2

High-throughput

0.536

High

488339

NAR5
Ecto-ADP-ribosyltransferase 5

1

1

High-throughput

0.536

High

488353

ABCF2
ATP-binding cassette sub-family F member 2

1

1

High-throughput

0.536

High

488303

KR108
Keratin-associated protein 10-8

1

8

High-throughput

0.523

High

488304

KR109
Keratin-associated protein 10-9

1

8

High-throughput

0.523

High

350676

NOE2
Noelin-2

1

0

High-throughput

0.513

High

424576

PAI1
Plasminogen activator inhibitor 1

1

0

High-throughput

0.513

High

488311

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

488317

RHEB
GTP-binding protein Rheb

1

0

High-throughput

0.513

High

488324

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.513

High

488330

NUBPL
Iron-sulfur cluster transfer protein NUBPL

1

0

High-throughput

0.513

High

488345

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.513

High

488349

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.513

High

488354

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

0

High-throughput

0.513

High

488298

RFC5
Replication factor C subunit 5

1

1

High-throughput

0.489

High

488299

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.489

High

488315

DPOD3
DNA polymerase delta subunit 3

1

1

High-throughput

0.489

High

488321

DRS7B
Dehydrogenase/reductase SDR family member 7B

1

1

High-throughput

0.489

High

488340

SFXN2
Sideroflexin-2

1

2

High-throughput

0.489

High

488341

SFXN3
Sideroflexin-3

1

2

High-throughput

0.489

High

488346

TPC
Mitochondrial thiamine pyrophosphate carrier

1

1

High-throughput

0.489

High

488351

ARL8B
ADP-ribosylation factor-like protein 8B

1

2

High-throughput

0.489

High

488356

ORNT1
Mitochondrial ornithine transporter 1

1

2

High-throughput

0.489

High

488347

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

1

Small-scale

0.481

High

362649

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

410546

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.479

High

488295

BASI
Basigin

1

2

High-throughput

0.479

High

488313

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

488326

TOR2X
Prosalusin

1

3

High-throughput

0.479

High

488333

TF3B
Transcription factor IIIB 90 kDa subunit

1

2

Small-scale

0.479

High

488352

HDAC6
Protein deacetylase HDAC6

1

3

High-throughput

0.479

High

488312

IF4A2
Eukaryotic initiation factor 4A-II

1

2

High-throughput

0.470

High

488297

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.458

High

488332

TITIN
Titin

1

0

High-throughput

0.458

High

488350

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

488302

KR103
Keratin-associated protein 10-3

1

8

High-throughput

0.439

High

488307

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.437

High

488316

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.437

High

488337

AURKB
Aurora kinase B

1

2

High-throughput

0.437

High

488293

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

488329

MSPD2
Motile sperm domain-containing protein 2

1

0

High-throughput

0.426

High

429182

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

488318

TOR2A
Torsin-2A

1

3

High-throughput

0.407

High

488322

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.407

High

488328

RDH13
Retinol dehydrogenase 13

2

0

High-throughput

0.328

High

488344

TBB1
Tubulin beta-1 chain

2

0

High-throughput

0.328

High

488310

IRF5
Interferon regulatory factor 5

1

0

Small-scale

0.292

High

415291

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.282

High

135769

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

488294

KTHY
Thymidylate kinase

1

0

High-throughput

0.279

Low

488300

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.279

Low

488314

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.279

Low

488319

SE1L3
Protein sel-1 homolog 3

1

0

High-throughput

0.279

Low

488331

TM263
Transmembrane protein 263

1

0

High-throughput

0.279

Low

488338

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.279

Low

488343

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.279

Low

488348

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.279

Low

488320

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

488327

MINK1
Misshapen-like kinase 1

1

0

High-throughput

0.249

Low

488342

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

Small-scale

0.249

Low

143386

E2F3
Transcription factor E2F3

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025