Protein: FANCJ
Fanconi anemia group J protein (EC 5.6.2.3) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (DNA 5'-3' helicase FANCJ)

Gene: FANCJ, BRIP1
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9BX63

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0003677 - DNA binding
GO:0003678 - DNA helicase activity
GO:0003724 - RNA helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926404

BLM
RecQ-like DNA helicase BLM

2

0

Small-scale

0.801

High

799453

BRCA1
Breast cancer type 1 susceptibility protein

38

3

Small-scale

0.771

High

827478

MLH1
DNA mismatch repair protein Mlh1

14

2

Small-scale

0.762

High

928707

PMS2
Mismatch repair endonuclease PMS2

6

2

Small-scale

0.735

High

1406768

BARD1
BRCA1-associated RING domain protein 1

6

2

Small-scale

0.725

High

1364239

TOPB1
DNA topoisomerase 2-binding protein 1

8

0

Small-scale

0.719

High

1416495

FANCJ
Fanconi anemia group J protein

1

0

Small-scale

0.674

High

1403565

MMS19
MMS19 nucleotide excision repair protein homolog

3

4

Small-scale

0.674

High

333168

VAPB
Vesicle-associated membrane protein-associated protein B/C

4

0

High-throughput

0.661

High

1326548

CARME
Carnosine N-methyltransferase

4

0

High-throughput

0.661

High

1116579

FHL3
Four and a half LIM domains protein 3

3

0

High-throughput

0.638

High

1416499

SG196
Protein O-mannose kinase

3

0

High-throughput

0.638

High

1416496

FACD2
Fanconi anemia group D2 protein

3

0

Small-scale

0.636

High

696408

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

Small-scale

0.634

High

139409

VMA5A
von Willebrand factor A domain-containing protein 5A

2

2

High-throughput

0.628

High

277471

AVIL
Advillin

2

2

High-throughput

0.628

High

1233789

CNDH2
Condensin-2 complex subunit H2

2

1

High-throughput

0.628

High

1333045

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

1

High-throughput

0.628

High

1416501

DOCK5
Dedicator of cytokinesis protein 5

2

1

High-throughput

0.628

High

928659

PMS1
PMS1 protein homolog 1

2

2

High-throughput

0.611

High

1360008

LIPH
Lipase member H

3

1

High-throughput

0.609

High

131076

TULP2
Tubby-related protein 2

2

0

High-throughput

0.602

High

892935

MRE11
Double-strand break repair protein MRE11

2

0

Small-scale

0.598

High

302943

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

2

6

Small-scale

0.584

High

386184

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

2

High-throughput

0.584

High

998763

H31
Histone H3.1

2

1

Small-scale

0.584

High

1314395

SLX4
Structure-specific endonuclease subunit SLX4

2

1

High-throughput

0.584

High

1416512

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

6

Small-scale

0.561

High

262128

NBN
Nibrin

2

0

Small-scale

0.559

High

292391

RA51D
DNA repair protein RAD51 homolog 4

1

3

High-throughput

0.536

High

549673

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

2

High-throughput

0.536

High

1054639

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.536

High

1144144

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

1382523

TRI52
E3 ubiquitin-protein ligase TRIM52

1

1

High-throughput

0.536

High

1416508

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

1

High-throughput

0.536

High

1416507

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.515

High

848712

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.513

High

1294954

PALB2
Partner and localizer of BRCA2

1

0

Small-scale

0.513

High

1324591

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1416497

DRC3
Dynein regulatory complex subunit 3

1

0

High-throughput

0.513

High

188359

HDAC3
Histone deacetylase 3

1

1

Small-scale

0.501

High

1368475

CBP
CREB-binding protein

1

3

Small-scale

0.501

High

1152615

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.493

High

190475

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.489

High

317747

NOL4
Nucleolar protein 4

1

1

High-throughput

0.489

High

1390345

I17RA
Interleukin-17 receptor A

1

2

High-throughput

0.489

High

1388713

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.480

High

138297

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.479

High

143231

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

474256

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.479

High

589596

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

769078

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

858804

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

1

Small-scale

0.479

High

881601

CDK8
Cyclin-dependent kinase 8

1

2

High-throughput

0.479

High

1017182

H33
Histone H3.3

1

1

High-throughput

0.479

High

1048085

TLE3
Transducin-like enhancer protein 3

1

2

High-throughput

0.479

High

1087988

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1114194

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1133639

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.479

High

1287011

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

1

Small-scale

0.479

High

1338937

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

1340803

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.479

High

1369760

RAD50
DNA repair protein RAD50

1

1

Small-scale

0.479

High

1387540

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

1416498

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

593200

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

697242

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

904374

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

958503

ACTZ
Alpha-centractin

1

0

High-throughput

0.458

High

986684

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1097539

CBX3
Chromobox protein homolog 3

1

0

Small-scale

0.458

High

1276739

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1279418

DPOLN
DNA polymerase nu

1

0

Small-scale

0.458

High

1313399

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1416500

CIAO3
Cytosolic iron-sulfur assembly component 3

1

0

Small-scale

0.458

High

1416504

ETAA1
Ewing's tumor-associated antigen 1

1

0

Small-scale

0.458

High

1416505

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1416509

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

1416510

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

386485

SPTA1
Spectrin alpha chain, erythrocytic 1

1

1

Small-scale

0.437

High

992320

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.426

High

1248949

ABRX1
BRCA1-A complex subunit Abraxas 1

1

0

Small-scale

0.426

High

1416506

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

1416503

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

3

0

High-throughput

0.347

High

1409640

DHB14
L-fucose dehydrogenase

3

0

High-throughput

0.346

High

1248580

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1416502

CRAC1
Cartilage acidic protein 1

2

0

High-throughput

0.328

High

252788

AP180
Clathrin coat assembly protein AP180

1

0

High-throughput

0.279

Low

1037080

OC90
Otoconin-90

1

0

High-throughput

0.279

Low

1416511

CRYL1
Lambda-crystallin homolog

1

0

High-throughput

0.279

Low

1208275

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025