Protein: MGME1
Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-)

Gene: MGME1
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q9BQP7

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006264 - mitochondrial DNA replication
GO:0008297 - single-stranded DNA exodeoxyribonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

777629

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

4

1

High-throughput

0.683

High

1410294

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

4

0

High-throughput

0.670

High

1410873

RM46
Large ribosomal subunit protein mL46

3

0

High-throughput

0.638

High

926114

DPOG1
DNA polymerase subunit gamma-1

3

0

High-throughput

0.634

High

1407325

MIPEP
Mitochondrial intermediate peptidase

3

0

High-throughput

0.634

High

1038687

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

2

0

High-throughput

0.602

High

1315348

THNS1
Threonine synthase-like 1

2

0

High-throughput

0.602

High

1410890

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

2

1

High-throughput

0.601

High

842230

THIM
3-ketoacyl-CoA thiolase, mitochondrial

2

0

High-throughput

0.576

High

1410877

TRI45
E3 ubiquitin-protein ligase TRIM45

2

1

High-throughput

0.574

High

279884

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1162516

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1410869

TR61B
tRNA

2

0

High-throughput

0.547

High

484629

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

658552

GCSH
Glycine cleavage system H protein, mitochondrial

1

0

High-throughput

0.513

High

728882

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1011356

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.513

High

1242616

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1323714

THEM5
Acyl-coenzyme A thioesterase THEM5

1

0

High-throughput

0.513

High

1380908

RAB24
Ras-related protein Rab-24

1

0

High-throughput

0.513

High

1410867

FEM1A
Protein fem-1 homolog A

1

0

High-throughput

0.513

High

1410868

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1410888

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

1410893

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

1410895

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

1410897

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.513

High

1410898

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

938786

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

1

High-throughput

0.489

High

61605

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.479

High

471210

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

1024158

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

1087517

GRSF1
G-rich sequence factor 1

1

2

High-throughput

0.479

High

183718

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

401383

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

519211

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

532904

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

828920

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841900

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

852007

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882845

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

927115

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

1048664

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058240

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1083722

MPPA
Mitochondrial-processing peptidase subunit alpha

1

0

High-throughput

0.458

High

1090515

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1117820

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1123398

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1142642

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1203454

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.458

High

1207121

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1234502

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1271521

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

1381689

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1386004

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

1388381

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1401593

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

1410871

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1410872

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1410875

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1410876

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1410880

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1410882

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1410883

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

0

High-throughput

0.458

High

1410896

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

72925

B1AK13
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

1

High-throughput

0.445

High

1410879

MDN1
Midasin

1

1

High-throughput

0.437

High

1244580

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

1350631

SFXN5
Sideroflexin-5

1

0

High-throughput

0.426

High

1410870

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.426

High

926835

VMAT1
Chromaffin granule amine transporter

1

1

High-throughput

0.407

High

1053056

VMAT2
Synaptic vesicular amine transporter

1

1

High-throughput

0.407

High

1410900

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

1

High-throughput

0.407

High

291956

WDHD1
WD repeat and HMG-box DNA-binding protein 1

2

0

High-throughput

0.328

High

1289974

LUZP1
Leucine zipper protein 1

2

0

High-throughput

0.328

High

1410891

CBLC
E3 ubiquitin-protein ligase CBL-C

2

0

High-throughput

0.328

High

1410878

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

482264

PAEP
Glycodelin

2

0

High-throughput

0.313

High

1086096

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.313

High

848931

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.282

High

167640

GIPC1
PDZ domain-containing protein GIPC1

1

0

High-throughput

0.279

Low

287470

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.279

Low

868981

NPTX2
Neuronal pentraxin-2

1

0

High-throughput

0.279

Low

937878

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.279

Low

1005029

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.279

Low

1009299

PRR3
Proline-rich protein 3

1

0

High-throughput

0.279

Low

1095937

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

0

High-throughput

0.279

Low

1130166

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

High-throughput

0.279

Low

1158501

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.279

Low

1218520

ZN691
Zinc finger protein 691

1

0

High-throughput

0.279

Low

1235320

STYK1
Tyrosine-protein kinase STYK1

1

0

High-throughput

0.279

Low

1290126

THOC4
THO complex subunit 4

1

0

High-throughput

0.279

Low

1328465

CMIP6
Ciliary microtubule inner protein 6

1

0

High-throughput

0.279

Low

1328929

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.279

Low

1332103

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.279

Low

1351024

DDX54
ATP-dependent RNA helicase DDX54

1

0

High-throughput

0.279

Low

1384744

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

High-throughput

0.279

Low

1394156

AJUBA
LIM domain-containing protein ajuba

1

0

High-throughput

0.279

Low

1408433

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.279

Low

1410874

TCAL2
Transcription elongation factor A protein-like 2

1

0

High-throughput

0.279

Low

1410885

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

1410892

SOX13
Transcription factor SOX-13

1

0

High-throughput

0.279

Low

1410894

SGT1
Protein SGT1 homolog

1

0

High-throughput

0.279

Low

1410899

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

1311073

LAX1
Lymphocyte transmembrane adapter 1

1

0

High-throughput

0.269

Low

1410886

DCDC2
Doublecortin domain-containing protein 2

1

0

High-throughput

0.268

Low

589536

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

607054

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

1054780

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.249

Low

1255273

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1256671

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.249

Low

1334841

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1390524

CDCA5
Sororin

1

0

High-throughput

0.249

Low

1410884

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

725802

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.232

Low

1090287

ELAV2
ELAV-like protein 2

1

0

High-throughput

0.232

Low

1281669

ZER1
Protein zer-1 homolog

1

0

High-throughput

0.232

Low

1410881

ASF1B
Histone chaperone ASF1B

1

0

High-throughput

0.232

Low

1410887

LAT2
Large neutral amino acids transporter small subunit 2

1

0

High-throughput

0.232

Low

1410889

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025