Protein: MED21
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)

Gene: MED21
Organism: Homo sapiens
Interactions: 169
UniProt ID: Q13503

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0001824 - blastocyst development
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0003899 - DNA-directed RNA polymerase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1108390

MED10
Mediator of RNA polymerase II transcription subunit 10

8

1

Small-scale

0.969

High

1108403

MED4
Mediator of RNA polymerase II transcription subunit 4

7

1

Small-scale

0.968

High

219485

MED7
Mediator of RNA polymerase II transcription subunit 7

7

3

Small-scale

0.965

High

239571

MED14
Mediator of RNA polymerase II transcription subunit 14

6

2

Small-scale

0.947

High

335986

MED26
Mediator of RNA polymerase II transcription subunit 26

8

0

Small-scale

0.924

High

1108407

MED9
Mediator of RNA polymerase II transcription subunit 9

9

0

Small-scale

0.922

High

881518

CDK8
Cyclin-dependent kinase 8

15

3

Small-scale

0.762

High

1108379

MED12
Mediator of RNA polymerase II transcription subunit 12

7

3

High-throughput

0.749

High

1108347

MED1
Mediator of RNA polymerase II transcription subunit 1

7

1

Small-scale

0.747

High

1108414

MED13
Mediator of RNA polymerase II transcription subunit 13

6

1

High-throughput

0.736

High

287786

MED6
Mediator of RNA polymerase II transcription subunit 6

6

1

Small-scale

0.734

High

666829

CCNC
Cyclin-C

6

1

High-throughput

0.732

High

1108394

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.730

High

48949

MED19
Mediator of RNA polymerase II transcription subunit 19

9

0

Small-scale

0.722

High

1108360

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

5

1

High-throughput

0.720

High

1108399

MED28
Mediator of RNA polymerase II transcription subunit 28

8

0

Small-scale

0.719

High

1108409

MED29
Mediator of RNA polymerase II transcription subunit 29

7

0

Small-scale

0.718

High

1108383

MED30
Mediator of RNA polymerase II transcription subunit 30

7

0

Small-scale

0.716

High

1108391

MED18
Mediator of RNA polymerase II transcription subunit 18

7

0

Small-scale

0.716

High

1108400

MED20
Mediator of RNA polymerase II transcription subunit 20

6

0

High-throughput

0.706

High

1108416

MED23
Mediator of RNA polymerase II transcription subunit 23

6

0

High-throughput

0.704

High

667294

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

0

Small-scale

0.702

High

1108365

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

4

1

High-throughput

0.697

High

1108387

MED15
Mediator of RNA polymerase II transcription subunit 15

4

2

High-throughput

0.697

High

282375

MED24
Mediator of RNA polymerase II transcription subunit 24

5

0

High-throughput

0.690

High

1108345

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

High-throughput

0.690

High

1108355

MED27
Mediator of RNA polymerase II transcription subunit 27

5

0

High-throughput

0.690

High

1108381

MED8
Mediator of RNA polymerase II transcription subunit 8

5

0

High-throughput

0.690

High

1108406

MED17
Mediator of RNA polymerase II transcription subunit 17

5

0

High-throughput

0.690

High

1108410

MED11
Mediator of RNA polymerase II transcription subunit 11

5

0

High-throughput

0.690

High

1108419

MED16
Mediator of RNA polymerase II transcription subunit 16

5

0

High-throughput

0.690

High

1108420

MED31
Mediator of RNA polymerase II transcription subunit 31

5

0

High-throughput

0.690

High

191909

MAGB4
Melanoma-associated antigen B4

3

2

High-throughput

0.675

High

192814

RPB4
DNA-directed RNA polymerase II subunit RPB4

4

0

High-throughput

0.667

High

1108341

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.663

High

1108361

MED25
Mediator of RNA polymerase II transcription subunit 25

4

0

High-throughput

0.661

High

912177

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.638

High

272652

BRE1B
E3 ubiquitin-protein ligase BRE1B

2

1

High-throughput

0.628

High

440544

FYN
Tyrosine-protein kinase Fyn

2

2

High-throughput

0.628

High

463087

YES
Tyrosine-protein kinase Yes

2

2

High-throughput

0.628

High

557286

SRC
Proto-oncogene tyrosine-protein kinase Src

2

2

High-throughput

0.628

High

1053661

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

1

High-throughput

0.628

High

1108352

BRE1A
E3 ubiquitin-protein ligase BRE1A

2

1

High-throughput

0.628

High

1108366

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.622

High

51358

SRCRL
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

3

1

High-throughput

0.616

High

533275

THA
Thyroid hormone receptor alpha

2

3

Small-scale

0.606

High

1108358

TRI72
Tripartite motif-containing protein 72

2

1

High-throughput

0.606

High

1108392

VAMP8
Vesicle-associated membrane protein 8

3

1

High-throughput

0.604

High

159198

ABLM1
Actin-binding LIM protein 1

2

0

High-throughput

0.602

High

188674

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

292445

PALM
Paralemmin-1

2

0

High-throughput

0.602

High

621867

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

1108357

FXL19
F-box/LRR-repeat protein 19

2

0

High-throughput

0.602

High

1108369

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

2

0

High-throughput

0.602

High

1108388

KIF2C
Kinesin-like protein KIF2C

2

0

High-throughput

0.602

High

1108422

KC1G3
Casein kinase I isoform gamma-3

2

0

High-throughput

0.602

High

621637

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.585

High

722954

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

770382

T2FA
General transcription factor IIF subunit 1

2

0

Small-scale

0.585

High

787746

RPB9
DNA-directed RNA polymerase II subunit RPB9

2

0

High-throughput

0.585

High

923495

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

0

High-throughput

0.585

High

976089

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.585

High

1025094

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.585

High

259906

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.584

High

618459

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

2

1

High-throughput

0.574

High

1108348

VAMP3
Vesicle-associated membrane protein 3

2

1

High-throughput

0.574

High

1108380

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

1108367

ZN655
Zinc finger protein 655

1

0

High-throughput

0.549

High

992162

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.543

High

571957

TRI27
Zinc finger protein RFP

1

1

High-throughput

0.541

High

799082

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.536

High

843538

HD
Huntingtin

1

0

High-throughput

0.518

High

1108346

TRBP2
RISC-loading complex subunit TARBP2

1

0

High-throughput

0.518

High

1108368

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.518

High

374574

RASH
GTPase HRas

1

0

High-throughput

0.513

High

625361

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

708894

T2EA
General transcription factor IIE subunit 1

1

0

Small-scale

0.513

High

1108359

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.513

High

1108371

CCNY
Cyclin-Y

1

0

High-throughput

0.513

High

1108376

TF2H4
General transcription factor IIH subunit 4

1

0

Small-scale

0.513

High

1108397

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.513

High

396054

ESR1
Estrogen receptor

1

3

Small-scale

0.501

High

533340

THB
Thyroid hormone receptor beta

1

3

Small-scale

0.501

High

833937

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

Small-scale

0.501

High

1108375

ESR2
Estrogen receptor beta

1

3

Small-scale

0.501

High

590423

GATA1
Erythroid transcription factor

1

1

Small-scale

0.500

High

167259

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

893486

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

1

High-throughput

0.489

High

848378

MAGA6
Melanoma-associated antigen 6

1

2

High-throughput

0.481

High

413778

P53
Cellular tumor antigen p53

1

0

Small-scale

0.480

High

142985

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.479

High

326330

SCAF4
SR-related and CTD-associated factor 4

1

1

High-throughput

0.479

High

473971

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.479

High

520019

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

543501

VDR
Vitamin D3 receptor

1

3

Small-scale

0.479

High

606731

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

787867

SRBP1
Sterol regulatory element-binding protein 1

1

1

Small-scale

0.479

High

1087726

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.479

High

1108349

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

2

High-throughput

0.479

High

1108351

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

1

High-throughput

0.479

High

1108377

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

1108378

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.479

High

1108384

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.479

High

1105887

LSAMP
Limbic system-associated membrane protein

1

1

High-throughput

0.470

High

163761

TCRG1
Transcription elongation regulator 1

1

0

Small-scale

0.458

High

190898

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

287453

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

316288

RECQ5
ATP-dependent DNA helicase Q5

1

0

High-throughput

0.458

High

897261

CDK7
Cyclin-dependent kinase 7

1

0

Small-scale

0.458

High

912055

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

919938

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.458

High

958941

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

983650

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1086575

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

1108396

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1108411

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.458

High

1108412

UXT
Protein UXT

1

0

High-throughput

0.458

High

95744

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1108374

PHF3
PHD finger protein 3

1

1

High-throughput

0.445

High

1108389

DIDO1
Death-inducer obliterator 1

1

2

High-throughput

0.445

High

1108353

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

1108342

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1108344

SAFB1
Scaffold attachment factor B1

1

0

High-throughput

0.426

High

1108363

DDX46
Probable ATP-dependent RNA helicase DDX46

1

0

High-throughput

0.426

High

1108385

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

0

High-throughput

0.426

High

1108401

NCOA5
Nuclear receptor coactivator 5

1

0

High-throughput

0.426

High

1108402

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

0

High-throughput

0.426

High

1108418

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

0

High-throughput

0.426

High

886829

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

76423

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

1108370

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.407

High

1108386

SPAG5
Sperm-associated antigen 5

3

0

High-throughput

0.345

High

1108417

STX8
Syntaxin-8

3

0

High-throughput

0.345

High

295819

FACE1
CAAX prenyl protease 1 homolog

2

0

High-throughput

0.328

High

297054

DHRS3
Short-chain dehydrogenase/reductase 3

2

0

High-throughput

0.328

High

333471

MPZL1
Myelin protein zero-like protein 1

2

0

High-throughput

0.328

High

337724

SGPL1
Sphingosine-1-phosphate lyase 1

2

0

High-throughput

0.328

High

607299

NEUM
Neuromodulin

2

0

High-throughput

0.328

High

659023

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

2

0

High-throughput

0.328

High

914532

EFNA5
Ephrin-A5

2

0

High-throughput

0.328

High

1058405

CKAP4
Cytoskeleton-associated protein 4

2

0

High-throughput

0.328

High

1088142

CNTN1
Contactin-1

2

0

High-throughput

0.328

High

1108343

I5P1
Inositol polyphosphate-5-phosphatase A

2

0

High-throughput

0.328

High

1108364

EEPD1
Endonuclease/exonuclease/phosphatase family domain-containing protein 1

2

0

High-throughput

0.328

High

1108395

ULBP2
UL16-binding protein 2

2

0

High-throughput

0.328

High

1108413

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.328

High

506008

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

3

0

High-throughput

0.319

High

169543

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.316

High

1108382

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.316

High

1108404

MID51
Mitochondrial dynamics protein MIEF1

2

0

High-throughput

0.316

High

1108354

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

2

0

High-throughput

0.305

High

1108415

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.299

High

1108398

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

0

High-throughput

0.282

High

387522

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.279

Low

387619

APOC2
Apolipoprotein C-II

1

0

High-throughput

0.279

Low

789636

HPCL1
Hippocalcin-like protein 1

1

0

High-throughput

0.279

Low

1108350

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.279

Low

1108356

ERIC5
Glutamate-rich protein 5

1

0

High-throughput

0.279

Low

1108372

OCC1
Overexpressed in colon carcinoma 1 protein

1

0

High-throughput

0.279

Low

1108373

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

High-throughput

0.279

Low

1108408

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.279

Low

1108421

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.279

Low

1108393

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

913648

VAV2
Guanine nucleotide exchange factor VAV2

1

0

High-throughput

0.265

Low

1108405

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.249

Low

225196

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

1

0

High-throughput

0.232

Low

536337

MTAP2
Microtubule-associated protein 2

1

0

High-throughput

0.232

Low

1108362

CCD80
Coiled-coil domain-containing protein 80

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025