Protein: GHR
Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)]

Gene: GHR
Organism: Homo sapiens
Interactions: 49
UniProt ID: P10912

Gene Ontology (top 5):
GO:0004903 - growth hormone receptor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

351705

SOMA
Somatotropin

7

2

Small-scale

0.961

High

146586

SOCS2
Suppressor of cytokine signaling 2

6

20

Small-scale

0.937

High

238338

JAK2
Tyrosine-protein kinase JAK2

4

20

Small-scale

0.873

High

500960

PTN11
Tyrosine-protein phosphatase non-receptor type 11

3

20

Small-scale

0.865

High

500977

FBW1A
F-box/WD repeat-containing protein 1A

3

6

Small-scale

0.861

High

500946

PTPRB
Receptor-type tyrosine-protein phosphatase beta

2

17

Small-scale

0.830

High

500974

CISH
Cytokine-inducible SH2-containing protein

2

20

Small-scale

0.792

High

500947

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

16

Small-scale

0.785

High

500973

PTPRH
Receptor-type tyrosine-protein phosphatase H

1

17

Small-scale

0.771

High

500944

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

10

Small-scale

0.768

High

500956

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.768

High

500970

DUS7
Dual specificity protein phosphatase 7

1

1

Small-scale

0.757

High

500940

GHR
Growth hormone receptor

2

16

Small-scale

0.737

High

181779

SOCS1
Suppressor of cytokine signaling 1

1

20

Small-scale

0.724

High

129180

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

Small-scale

0.647

High

147382

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.647

High

441167

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

High-throughput

0.647

High

500949

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.647

High

500951

STAT3
Signal transducer and activator of transcription 3

1

20

Small-scale

0.647

High

500954

STA5B
Signal transducer and activator of transcription 5B

1

20

Small-scale

0.647

High

500961

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

19

High-throughput

0.647

High

500962

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

Small-scale

0.647

High

500966

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

17

High-throughput

0.647

High

435509

IGF1R
Insulin-like growth factor 1 receptor

1

9

Small-scale

0.618

High

500941

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.618

High

500945

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.618

High

500948

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

High-throughput

0.618

High

500950

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.618

High

500953

CRK
Adapter molecule crk

1

20

High-throughput

0.618

High

500963

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.618

High

500958

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.614

High

500942

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

20

Small-scale

0.608

High

500943

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

Small-scale

0.608

High

213467

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

6

Small-scale

0.561

High

500976

CHIP
E3 ubiquitin-protein ligase CHIP

1

8

Small-scale

0.561

High

500952

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

20

Small-scale

0.545

High

500957

SKP1
S-phase kinase-associated protein 1

2

0

Small-scale

0.539

High

500959

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.501

High

500978

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

20

High-throughput

0.501

High

500965

NCOA6
Nuclear receptor coactivator 6

1

1

Small-scale

0.457

High

500955

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.408

High

500964

CUL1
Cullin-1

1

3

Small-scale

0.408

High

500967

ELOC
Elongin-C

1

1

Small-scale

0.408

High

500968

ELOB
Elongin-B

1

1

Small-scale

0.408

High

500972

CUL5
Cullin-5

1

3

Small-scale

0.408

High

500975

RBX2
RING-box protein 2

1

1

Small-scale

0.408

High

500969

NEDD8
NEDD8

1

0

Small-scale

0.391

High

500971

FBX31
F-box only protein 31

1

0

Small-scale

0.391

High


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Last updated: 15 Jul 2024