Protein: MANF
Mesencephalic astrocyte-derived neurotrophic factor (Arginine-rich protein) (Protein ARMET)

Gene: MANF
Organism: Homo sapiens
Interactions: 82
UniProt ID: P55145

Gene Ontology (top 5):
GO:0002014 - vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
GO:0003723 - RNA binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

936188

CDNF
Cerebral dopamine neurotrophic factor

2

0

High-throughput

0.716

High

534835

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.631

High

936190

B2L15
Bcl-2-like protein 15

2

0

High-throughput

0.585

High

936205

R51A1
RAD51-associated protein 1

2

0

High-throughput

0.576

High

936184

RTN1
Reticulon-1

1

0

Small-scale

0.561

High

274517

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

582319

ARSA
Arylsulfatase A

1

0

High-throughput

0.513

High

601956

ZNF8
Zinc finger protein 8

1

0

High-throughput

0.513

High

650666

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.513

High

665562

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.513

High

922556

AP2S1
AP-2 complex subunit sigma

1

0

High-throughput

0.513

High

936185

MICB
MHC class I polypeptide-related sequence B

1

0

High-throughput

0.513

High

936202

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

0

High-throughput

0.513

High

936207

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

936214

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

936215

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

936217

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

936222

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.513

High

936225

NTNG1
Netrin-G1

1

0

High-throughput

0.513

High

936226

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.513

High

161438

KMT2D
Histone-lysine N-methyltransferase 2D

1

0

High-throughput

0.493

High

193064

FGF10
Fibroblast growth factor 10

1

0

High-throughput

0.493

High

213584

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.493

High

286351

DAB1
Disabled homolog 1

1

0

High-throughput

0.493

High

680685

CATS
Cathepsin S

1

0

High-throughput

0.493

High

692901

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.493

High

936182

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.493

High

936192

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.493

High

936193

ABRX1
BRCA1-A complex subunit Abraxas 1

1

0

High-throughput

0.493

High

936210

CFA74
Cilia- and flagella-associated protein 74

1

0

High-throughput

0.493

High

936213

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

0

High-throughput

0.493

High

936220

FMN2
Formin-2

1

0

High-throughput

0.493

High

218012

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

460791

CATB
Cathepsin B

1

1

High-throughput

0.479

High

720168

UFO
Tyrosine-protein kinase receptor UFO

1

2

High-throughput

0.479

High

820614

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.479

High

936189

EPHAA
Ephrin type-A receptor 10

1

1

High-throughput

0.479

High

936191

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

936208

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

1

High-throughput

0.479

High

936212

TAOK3
Serine/threonine-protein kinase TAO3

1

1

High-throughput

0.470

High

241211

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

390504

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

521602

H14
Histone H1.4

1

0

High-throughput

0.458

High

566603

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.458

High

567321

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

606502

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

772119

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

866936

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

936177

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

936178

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

936179

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

936180

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

936183

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

936186

TECT1
Tectonic-1

1

0

High-throughput

0.458

High

936187

PAR15
Protein mono-ADP-ribosyltransferase PARP15

1

0

High-throughput

0.458

High

936197

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

936199

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

936201

TITIN
Titin

1

0

High-throughput

0.458

High

936203

SFRP3
Secreted frizzled-related protein 3

1

0

High-throughput

0.458

High

936204

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

936206

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

936209

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.458

High

936211

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

936221

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

936223

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

529429

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

936181

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.445

High

183389

MATN3
Matrilin-3

1

0

Small-scale

0.426

High

936200

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.426

High

936224

ADA21
Disintegrin and metalloproteinase domain-containing protein 21

2

0

High-throughput

0.328

High

936196

ZDH17
Palmitoyltransferase ZDHHC17

1

0

High-throughput

0.282

High

138816

STK25
Serine/threonine-protein kinase 25

1

0

High-throughput

0.279

Low

227839

MYO1B
Unconventional myosin-Ib

1

0

High-throughput

0.279

Low

231221

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

1

0

High-throughput

0.279

Low

936198

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.279

Low

936216

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

936227

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

554789

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.269

Low

936218

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.269

Low

936194

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low

936195

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

936219

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025