Protein: NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) (TYKY subunit)

Gene: NDUS8, NDUFS8
Organism: Homo sapiens
Interactions: 174
UniProt ID: O00217

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix
GO:0006120 - mitochondrial electron transport, NADH to ubiquinone
GO:0008137 - NADH dehydrogenase (ubiquinone) activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

127433

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

3

3

High-throughput

0.871

High

127434

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

3

0

High-throughput

0.827

High

127589

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

2

0

High-throughput

0.748

High

127455

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

2

0

High-throughput

0.736

High

127437

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

5

3

High-throughput

0.718

High

127427

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

1

High-throughput

0.691

High

127467

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

1

High-throughput

0.691

High

127534

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

3

1

High-throughput

0.650

High

127470

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

3

0

High-throughput

0.638

High

127540

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

3

0

High-throughput

0.638

High

127584

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

3

0

High-throughput

0.634

High

127583

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

3

0

High-throughput

0.622

High

127431

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

2

0

High-throughput

0.602

High

127570

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.602

High

127578

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

2

0

High-throughput

0.602

High

127514

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

High-throughput

0.595

High

127493

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

127499

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

2

0

High-throughput

0.576

High

127488

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

127498

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

127580

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.559

High

127446

ESR1
Estrogen receptor

2

1

High-throughput

0.521

High

127426

NDUA1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1

1

0

High-throughput

0.513

High

127429

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.513

High

127430

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

0

High-throughput

0.513

High

127441

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.513

High

127454

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.513

High

127473

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.513

High

127513

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

0

High-throughput

0.513

High

127545

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

0

High-throughput

0.513

High

127436

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

127438

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

127464

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

127487

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

127495

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

High-throughput

0.479

High

127505

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

127511

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

3

High-throughput

0.479

High

127517

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

127520

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

127521

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

127522

FAKD4
FAST kinase domain-containing protein 4

1

3

High-throughput

0.479

High

127523

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

127525

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

127526

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

127535

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

127537

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

127539

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

127549

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

127555

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

127556

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.479

High

127562

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

127575

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

127581

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

3

High-throughput

0.479

High

127587

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

127595

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

61355

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66077

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

127424

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

127425

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

127428

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

127432

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

127435

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

127440

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

127442

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

127444

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

127445

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

127447

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

127450

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

127451

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

127453

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

127456

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

127457

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

127458

HSPA9
Stress-70 protein, mitochondrial

1

0

High-throughput

0.458

High

127460

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

127462

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

127463

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

127466

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

127481

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

127483

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

127484

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

127485

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

127486

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

127492

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

127497

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

127503

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

127506

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.458

High

127509

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

127510

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.458

High

127524

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

127527

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

0

High-throughput

0.458

High

127528

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

127529

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

127530

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

127533

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

127536

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

127541

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

127542

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

127543

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

127544

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

127546

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

127547

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

127548

TR61B
tRNA

1

0

High-throughput

0.458

High

127550

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

127551

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

127553

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

127554

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

127558

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

0

High-throughput

0.458

High

127560

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

127561

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

127563

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

127566

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

127567

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

127568

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

127569

NGRN
Neugrin

1

0

High-throughput

0.458

High

127571

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

127572

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.458

High

127574

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

127576

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

127577

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

127586

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

127593

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

127475

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.437

High

127477

RHOA
Transforming protein RhoA

1

2

High-throughput

0.437

High

127482

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

127496

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.437

High

127504

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

127531

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

127585

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.437

High

127594

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.437

High

127474

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

Small-scale

0.426

High

127501

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

127480

S35B1
Solute carrier family 35 member B1

1

1

High-throughput

0.407

High

127519

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

1

High-throughput

0.407

High

127557

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

127559

CHST8
Carbohydrate sulfotransferase 8

1

0

High-throughput

0.279

Low

127471

GEM
GTP-binding protein GEM

1

0

High-throughput

0.265

Low

127449

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

127439

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

127443

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.249

Low

127452

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

127468

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

127469

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.249

Low

127472

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

127476

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.249

Low

127478

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

127479

H4
Histone H4

1

0

High-throughput

0.249

Low

127489

DUS8
Dual specificity protein phosphatase 8

1

0

High-throughput

0.249

Low

127490

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.249

Low

127491

CUL3
Cullin-3

1

0

High-throughput

0.249

Low

127500

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

127502

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

127507

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

127508

CE128
Centrosomal protein of 128 kDa

1

0

High-throughput

0.249

Low

127512

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

127515

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.249

Low

127518

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

127532

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

127538

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.249

Low

127552

MTMRC
Myotubularin-related protein 12

1

0

High-throughput

0.249

Low

127564

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

127565

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

127573

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

127579

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

127582

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

127588

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

127590

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

Small-scale

0.249

Low

127459

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.238

Low

127448

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

127461

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

127465

S6A12
Sodium- and chloride-dependent betaine transporter

1

0

High-throughput

0.232

Low

127494

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

127516

S39AB
Zinc transporter ZIP11

1

0

High-throughput

0.232

Low

127591

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low

127592

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025