Protein: SPSB1
SPRY domain-containing SOCS box protein 1 (SSB-1)

Gene: SPSB1
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q96BD6

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1147090

ELOC
Elongin-C

3

6

Small-scale

0.849

High

1371825

CUL5
Cullin-5

1

20

Small-scale

0.691

High

1382360

SPSB4
SPRY domain-containing SOCS box protein 4

1

14

High-throughput

0.691

High

766216

NOS2
Nitric oxide synthase, inducible

4

7

Small-scale

0.680

High

216507

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

1

High-throughput

0.662

High

635741

RASA1
Ras GTPase-activating protein 1

1

12

Small-scale

0.618

High

1384495

SPSB1
SPRY domain-containing SOCS box protein 1

1

16

Small-scale

0.618

High

1147235

ELOB
Elongin-B

2

4

Small-scale

0.611

High

1384498

TTC1
Tetratricopeptide repeat protein 1

2

14

High-throughput

0.601

High

1384499

ANM1
Protein arginine N-methyltransferase 1

1

15

High-throughput

0.573

High

1102223

ATM
Serine-protein kinase ATM

1

12

Small-scale

0.561

High

139405

VMA5A
von Willebrand factor A domain-containing protein 5A

2

6

High-throughput

0.553

High

1380805

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.541

High

1384496

PAWR
PRKC apoptosis WT1 regulator protein

1

4

Small-scale

0.536

High

1384502

RBX2
RING-box protein 2

1

10

Small-scale

0.536

High

246843

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.523

High

1384497

ANM6
Protein arginine N-methyltransferase 6

1

15

High-throughput

0.523

High

131002

HIP1
Huntingtin-interacting protein 1

1

15

High-throughput

0.515

High

242526

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.515

High

384511

CRYAA
Alpha-crystallin A chain

1

4

High-throughput

0.515

High

474880

VIME
Vimentin

1

11

High-throughput

0.515

High

593775

PECA1
Platelet endothelial cell adhesion molecule

1

20

High-throughput

0.515

High

937082

CASP6
Caspase-6

1

6

High-throughput

0.515

High

957640

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

13

High-throughput

0.515

High

981629

RAN
GTP-binding nuclear protein Ran

1

15

High-throughput

0.515

High

1096475

PAK1
Serine/threonine-protein kinase PAK 1

1

16

High-throughput

0.515

High

1384503

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

1384500

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.494

High

186785

P73
Tumor protein p73

1

8

High-throughput

0.479

High

350101

SNAI1
Zinc finger protein SNAI1

1

5

Small-scale

0.479

High

375820

RASK
GTPase KRas

1

13

Small-scale

0.479

High

414373

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

461791

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.479

High

468675

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.479

High

710877

EPHB2
Ephrin type-B receptor 2

1

13

Small-scale

0.479

High

788986

TGFR2
TGF-beta receptor type-2

1

3

Small-scale

0.479

High

1045617

TF65
Transcription factor p65

1

10

Small-scale

0.479

High

1384501

DDX4
Probable ATP-dependent RNA helicase DDX4

1

13

Small-scale

0.472

High

562297

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.470

High

720012

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.470

High

1096149

TADBP
TAR DNA-binding protein 43

1

12

High-throughput

0.470

High

472112

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.437

High

1109487

ATR
Serine/threonine-protein kinase ATR

1

11

Small-scale

0.437

High

1360338

ATRIP
ATR-interacting protein

1

1

Small-scale

0.437

High

404871

PRIO
Major prion protein

1

0

High-throughput

0.426

High

933084

ADPRH
ADP-ribosylhydrolase ARH1

2

0

High-throughput

0.316

High

441560

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025