Protein: PLPHP
Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) (Proline synthase co-transcribed bacterial homolog protein) (Pyridoxal phosphate-binding protein)

Gene: PLPHP, PLPBP
Organism: Homo sapiens
Interactions: 67
UniProt ID: O94903

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0030170 - pyridoxal phosphate binding
GO:0042816 - vitamin B6 metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

321081

SOX2
Transcription factor SOX-2

2

0

High-throughput

0.585

High

321094

CD5R1
Cyclin-dependent kinase 5 activator 1

2

0

High-throughput

0.585

High

321114

OXND1
Oxidoreductase NAD-binding domain-containing protein 1

2

0

High-throughput

0.585

High

321120

S2532
Solute carrier family 25 member 32

2

0

High-throughput

0.585

High

249702

DOK2
Docking protein 2

2

1

High-throughput

0.571

High

321078

RASA1
Ras GTPase-activating protein 1

2

0

High-throughput

0.547

High

321090

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

0

High-throughput

0.547

High

321132

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

2

0

High-throughput

0.547

High

273384

KDM4A
Lysine-specific demethylase 4A

1

1

High-throughput

0.536

High

321126

KDM5B
Lysine-specific demethylase 5B

1

1

High-throughput

0.536

High

321084

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

321095

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

High-throughput

0.513

High

321098

FRPD2
FERM and PDZ domain-containing protein 2

1

0

High-throughput

0.513

High

321099

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

321103

NUD13
NAD(P)H pyrophosphatase NUDT13, mitochondrial

1

0

High-throughput

0.513

High

321107

DAAF4
Dynein axonemal assembly factor 4

1

0

High-throughput

0.513

High

321116

FMNL2
Formin-like protein 2

1

0

High-throughput

0.513

High

321119

PAR6B
Partitioning defective 6 homolog beta

1

0

High-throughput

0.513

High

321122

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

321128

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

0

High-throughput

0.513

High

321096

SMU1
WD40 repeat-containing protein SMU1

1

1

High-throughput

0.479

High

321121

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

131638

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

143776

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

0

High-throughput

0.458

High

283742

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.458

High

321075

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

321082

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

321085

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

321086

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

321093

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

321101

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

321102

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

321106

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.458

High

321108

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

321112

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.458

High

321118

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

321124

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

321125

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

321130

ST38L
Serine/threonine-protein kinase 38-like

1

0

High-throughput

0.458

High

321097

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

321113

SYMM
Methionine--tRNA ligase, mitochondrial

1

1

High-throughput

0.445

High

142258

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.426

High

321074

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

321088

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.426

High

321092

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

321105

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

321110

HPS1
BLOC-3 complex member HPS1

1

0

High-throughput

0.426

High

321111

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.426

High

321123

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

321129

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

321117

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.328

High

321077

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

2

0

High-throughput

0.318

High

321083

CAV2
Caveolin-2

2

0

High-throughput

0.298

High

321100

RHG36
Rho GTPase-activating protein 36

2

0

High-throughput

0.298

High

321076

CFC1
Cryptic protein

1

0

High-throughput

0.279

Low

321080

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.279

Low

321089

SATB1
DNA-binding protein SATB1

1

0

High-throughput

0.279

Low

321109

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.279

Low

321115

TM101
Transmembrane protein 101

1

0

High-throughput

0.279

Low

321127

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.279

Low

321087

TRA2B
Transformer-2 protein homolog beta

1

0

High-throughput

0.249

Low

321091

SRSF6
Serine/arginine-rich splicing factor 6

1

0

High-throughput

0.249

Low

321104

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.249

Low

321131

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

297894

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.232

Low

321073

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

321079

CD27
CD27 antigen

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025