Protein: MCM8
DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8)

Gene: MCM8
Organism: Homo sapiens
Interactions: 57
UniProt ID: Q9UJA3

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0003682 - chromatin binding
GO:0003697 - single-stranded DNA binding
GO:0004386 - helicase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1452062

MCM9
DNA helicase MCM9

8

19

Small-scale

0.967

High

756081

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.691

High

1413476

MCMBP
Mini-chromosome maintenance complex-binding protein

3

20

Small-scale

0.656

High

139426

VMA5A
von Willebrand factor A domain-containing protein 5A

2

1

High-throughput

0.628

High

457761

TBB5
Tubulin beta chain

2

13

High-throughput

0.628

High

1101925

SKP2
S-phase kinase-associated protein 2

2

2

High-throughput

0.628

High

1330843

TSYL6
Testis-specific Y-encoded-like protein 6

2

6

High-throughput

0.628

High

755815

MCM4
DNA replication licensing factor MCM4

1

19

Small-scale

0.618

High

756400

MCM7
DNA replication licensing factor MCM7

1

20

Small-scale

0.618

High

1128308

MCM6
DNA replication licensing factor MCM6

1

20

Small-scale

0.618

High

1460566

MCM8
DNA helicase MCM8

1

18

Small-scale

0.618

High

827517

MLH1
DNA mismatch repair protein Mlh1

2

5

Small-scale

0.611

High

846696

MSH2
DNA mismatch repair protein Msh2

2

4

Small-scale

0.611

High

1395447

FEM1C
Protein fem-1 homolog C

2

3

High-throughput

0.606

High

366269

FA9
Coagulation factor IX

2

1

High-throughput

0.574

High

1180414

KLH40
Kelch-like protein 40

2

8

High-throughput

0.574

High

1252609

DEFI8
Differentially expressed in FDCP 8 homolog

2

1

High-throughput

0.574

High

1421306

LRC27
Leucine-rich repeat-containing protein 27

2

1

High-throughput

0.574

High

1460567

PSG8
Pregnancy-specific beta-1-glycoprotein 8

2

4

High-throughput

0.574

High

1460568

KLK5
Kallikrein-5

2

1

High-throughput

0.558

High

571006

MIF
Macrophage migration inhibitory factor

1

4

High-throughput

0.536

High

606052

CAN2
Calpain-2 catalytic subunit

1

1

High-throughput

0.536

High

634688

LMNB1
Lamin-B1

1

12

High-throughput

0.536

High

642599

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

4

High-throughput

0.536

High

913426

MSH6
DNA mismatch repair protein Msh6

1

4

High-throughput

0.536

High

1144209

TEBP
Prostaglandin E synthase 3

1

5

High-throughput

0.536

High

1330475

HORM2
HORMA domain-containing protein 2

1

2

High-throughput

0.536

High

535656

BIP
Endoplasmic reticulum chaperone BiP

1

12

High-throughput

0.515

High

1325202

HROB
Homologous recombination OB-fold protein

1

1

Small-scale

0.515

High

191416

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

1

0

High-throughput

0.513

High

277478

AVIL
Advillin

1

2

High-throughput

0.489

High

518632

RAP2A
Ras-related protein Rap-2a

1

1

High-throughput

0.489

High

773685

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.489

High

173520

XPO1
Exportin-1

1

7

High-throughput

0.479

High

903276

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

9

High-throughput

0.479

High

1104380

ORC2
Origin recognition complex subunit 2

1

11

Small-scale

0.479

High

1106114

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

14

High-throughput

0.479

High

1130913

PSF1
DNA replication complex GINS protein PSF1

1

13

Small-scale

0.479

High

1292824

SKAP1
Src kinase-associated phosphoprotein 1

1

11

High-throughput

0.479

High

1314882

FANCM
Fanconi anemia group M protein

1

20

Small-scale

0.479

High

1369795

RAD50
DNA repair protein RAD50

1

20

Small-scale

0.479

High

1406958

CDC6
Cell division control protein 6 homolog

1

20

Small-scale

0.479

High

1459232

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1460276

XPO7
Exportin-7

1

6

High-throughput

0.479

High

1085849

TF3C1
General transcription factor 3C polypeptide 1

1

0

High-throughput

0.458

High

1452702

DONS
Protein downstream neighbor of Son

1

5

Small-scale

0.445

High

1418504

ACE2
Angiotensin-converting enzyme 2

1

2

Small-scale

0.437

High

349715

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.279

Low

1323707

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

0

High-throughput

0.279

Low

1329555

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.279

Low

1381167

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

1390365

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1396462

F167A
Protein FAM167A

1

0

High-throughput

0.279

Low

1011402

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.269

Low

517312

GAGE1
G antigen 1

1

0

High-throughput

0.232

Low

1081724

YL016
Putative uncharacterized protein LOC100128554

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025