Protein: NPCL1
NPC1-like intracellular cholesterol transporter 1 (NPC1L1) (Niemann-Pick C1-like protein 1)

Gene: NPCL1, NPC1L1
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q9UHC9

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006695 - cholesterol biosynthetic process
GO:0008431 - vitamin E binding
GO:0015485 - cholesterol binding
GO:0015918 - sterol transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1085484

SRBP2
Sterol regulatory element-binding protein 2

1

3

Small-scale

0.479

High

1114573

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1416699

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.479

High

635225

HNF1A
Hepatocyte nuclear factor 1-alpha

1

0

Small-scale

0.458

High

277043

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

1

High-throughput

0.445

High

380597

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

4

High-throughput

0.445

High

995501

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.445

High

1105833

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

1

High-throughput

0.445

High

1142425

PDIA6
Protein disulfide-isomerase A6

1

4

High-throughput

0.445

High

1143811

PON2
Serum paraoxonase/arylesterase 2

1

1

High-throughput

0.445

High

1214924

WLS
Protein wntless homolog

1

1

High-throughput

0.445

High

1430456

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

2

High-throughput

0.445

High

1459741

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.445

High

1459814

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.445

High

1203146

SGMR2
Sigma intracellular receptor 2

1

0

High-throughput

0.426

High

169155

ML12B
Myosin regulatory light chain 12B

1

1

High-throughput

0.407

High

171004

CLGN
Calmegin

1

9

High-throughput

0.407

High

249270

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

1

2

High-throughput

0.407

High

344035

HS74L
Heat shock 70 kDa protein 4L

1

3

High-throughput

0.407

High

373420

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.407

High

566869

PDIA4
Protein disulfide-isomerase A4

1

5

High-throughput

0.407

High

573717

ENPL
Endoplasmin

1

1

High-throughput

0.407

High

698062

CALR
Calreticulin

1

9

High-throughput

0.407

High

699232

CALX
Calnexin

1

9

High-throughput

0.407

High

717634

PDIA3
Protein disulfide-isomerase A3

1

6

High-throughput

0.407

High

863580

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

4

High-throughput

0.407

High

975569

SELT
Thioredoxin reductase-like selenoprotein T

1

1

High-throughput

0.407

High

994966

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

1

High-throughput

0.407

High

1098498

DNJC3
DnaJ homolog subfamily C member 3

1

3

High-throughput

0.407

High

1238706

TM214
Transmembrane protein 214

1

1

High-throughput

0.407

High

1312086

DJC10
DnaJ homolog subfamily C member 10

1

8

High-throughput

0.407

High

1333718

UBAC2
Ubiquitin-associated domain-containing protein 2

1

1

High-throughput

0.407

High

1349865

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

4

High-throughput

0.407

High

1352546

GPX8
Probable glutathione peroxidase 8

1

2

High-throughput

0.407

High

1357343

THEM6
Protein THEM6

1

2

High-throughput

0.407

High

1395880

CLP1L
Lipid scramblase CLPTM1L

1

2

High-throughput

0.407

High

1406732

SGMR1
Sigma non-opioid intracellular receptor 1

1

1

High-throughput

0.407

High

1439374

SDF2L
Stromal cell-derived factor 2-like protein 1

1

5

High-throughput

0.407

High

1452809

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

1

High-throughput

0.407

High

1459815

DJC16
DnaJ homolog subfamily C member 16

1

8

High-throughput

0.407

High

1459816

FND3A
Fibronectin type-III domain-containing protein 3A

1

4

High-throughput

0.407

High

469228

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.232

Low

944349

TMM33
Transmembrane protein 33

1

0

High-throughput

0.232

Low

995876

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.232

Low

1337012

DIK2A
Divergent protein kinase domain 2A

1

0

High-throughput

0.232

Low

1394412

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

High-throughput

0.232

Low

1458686

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025