Protein: FA12
Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]

Gene: FA12, F12
Organism: Homo sapiens
Interactions: 73
UniProt ID: P00748

Gene Ontology (top 5):
GO:0002353 - plasma kallikrein-kinin cascade
GO:0002542 - Factor XII activation
GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341412

A4
Amyloid-beta precursor protein

1

15

High-throughput

0.665

High

341410

FA12
Coagulation factor XII

1

14

Small-scale

0.647

High

341413

GP1BA
Platelet glycoprotein Ib alpha chain

1

6

Small-scale

0.647

High

341435

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.647

High

341416

HSP7C
Heat shock cognate 71 kDa protein

2

5

High-throughput

0.628

High

341467

ARHG4
Rho guanine nucleotide exchange factor 4

1

2

High-throughput

0.618

High

341442

ANR40
Ankyrin repeat domain-containing protein 40

2

1

High-throughput

0.574

High

341411

TBB4A
Tubulin beta-4A chain

1

11

High-throughput

0.536

High

341414

TBB5
Tubulin beta chain

1

11

High-throughput

0.536

High

341418

HSP76
Heat shock 70 kDa protein 6

1

5

High-throughput

0.536

High

341428

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.536

High

341432

TBA4A
Tubulin alpha-4A chain

1

11

High-throughput

0.536

High

341433

PRAME
Melanoma antigen preferentially expressed in tumors

1

1

High-throughput

0.536

High

341446

TBA1A
Tubulin alpha-1A chain

1

11

High-throughput

0.536

High

341472

DD19B
ATP-dependent RNA helicase DDX19B

1

2

High-throughput

0.536

High

341473

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

High-throughput

0.536

High

341474

NEUR3
Sialidase-3

1

1

High-throughput

0.536

High

341438

HIF1A
Hypoxia-inducible factor 1-alpha

1

3

Small-scale

0.528

High

341417

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.515

High

341419

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.513

High

341434

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.513

High

341453

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

0

High-throughput

0.513

High

341465

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

0

High-throughput

0.513

High

341470

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

0

High-throughput

0.513

High

341459

EPAS1
Endothelial PAS domain-containing protein 1

1

3

Small-scale

0.512

High

341429

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

5

Small-scale

0.501

High

341430

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

5

Small-scale

0.501

High

341431

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

5

Small-scale

0.501

High

72702

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

1

High-throughput

0.489

High

182306

PER1
Period circadian protein homolog 1

1

4

High-throughput

0.489

High

215412

SCO2
Protein SCO2 homolog, mitochondrial

1

2

High-throughput

0.489

High

294245

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.489

High

324151

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.489

High

341421

ETV3
ETS translocation variant 3

1

2

High-throughput

0.489

High

341436

PEX6
Peroxisomal ATPase PEX6

1

1

High-throughput

0.489

High

341437

CUL7
Cullin-7

1

2

High-throughput

0.489

High

341443

ACD10
Acyl-CoA dehydrogenase family member 10

1

2

High-throughput

0.489

High

341444

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

1

High-throughput

0.489

High

341448

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.489

High

341450

NEDD1
Protein NEDD1

1

1

High-throughput

0.489

High

341460

TEP1
Telomerase protein component 1

1

2

High-throughput

0.489

High

341461

TBA1C
Tubulin alpha-1C chain

1

11

High-throughput

0.489

High

341469

RNF12
E3 ubiquitin-protein ligase RLIM

1

3

High-throughput

0.489

High

341471

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.489

High

341420

NF1
Neurofibromin

1

0

Small-scale

0.458

High

341424

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

5

Small-scale

0.457

High

341425

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

5

Small-scale

0.457

High

341415

HS71B
Heat shock 70 kDa protein 1B

1

5

High-throughput

0.445

High

341449

PJA1
E3 ubiquitin-protein ligase Praja-1

1

1

High-throughput

0.437

High

277225

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

341423

CACP
Carnitine O-acetyltransferase

1

0

High-throughput

0.279

Low

341426

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.279

Low

341427

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.279

Low

341439

WDR81
WD repeat-containing protein 81

1

0

High-throughput

0.279

Low

341440

PR14L
Protein PRR14L

1

0

High-throughput

0.279

Low

341441

ZMYM4
Zinc finger MYM-type protein 4

1

0

High-throughput

0.279

Low

341445

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.279

Low

341447

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.279

Low

341451

SHKB1
SH3KBP1-binding protein 1

1

0

High-throughput

0.279

Low

341452

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.279

Low

341454

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

0

High-throughput

0.279

Low

341455

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

341457

ATX2
Ataxin-2

1

0

High-throughput

0.279

Low

341458

METH
Methionine synthase

1

0

High-throughput

0.279

Low

341462

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

341464

ESRP2
Epithelial splicing regulatory protein 2

1

0

High-throughput

0.279

Low

341466

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

341468

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.279

Low

167196

MRPP3
Mitochondrial ribonuclease P catalytic subunit

1

0

High-throughput

0.249

Low

341456

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.249

Low

341463

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

High-throughput

0.249

Low

341422

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024