Protein: KLH11
Kelch-like protein 11

Gene: KLH11, KLHL11
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q9NVR0

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1990756 - ubiquitin-like ligase-substrate adaptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114434

CUL3
Cullin-3

8

20

Small-scale

0.967

High

1450769

UBQL2
Ubiquilin-2

2

2

High-throughput

0.783

High

1450765

KLH11
Kelch-like protein 11

2

19

High-throughput

0.757

High

169277

CASQ2
Calsequestrin-2

3

2

High-throughput

0.667

High

1448364

PICK1
PRKCA-binding protein

3

1

High-throughput

0.667

High

508712

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.647

High

1350269

RHPN1
Rhophilin-1

2

4

High-throughput

0.628

High

1220841

RN123
E3 ubiquitin-protein ligase RNF123

2

3

High-throughput

0.601

High

1136607

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

16

High-throughput

0.575

High

1295801

C1QL4
Complement C1q-like protein 4

2

3

High-throughput

0.574

High

1007989

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.553

High

126261

ST2B1
Sulfotransferase 2B1

1

1

High-throughput

0.536

High

248793

PEPL
Periplakin

1

6

High-throughput

0.536

High

259137

DNJA2
DnaJ homolog subfamily A member 2

1

5

High-throughput

0.536

High

289286

SPB7
Serpin B7

1

6

High-throughput

0.536

High

457926

INVO
Involucrin

1

4

High-throughput

0.536

High

553734

ANXA3
Annexin A3

1

1

High-throughput

0.536

High

568984

ANXA8
Annexin A8

1

1

High-throughput

0.536

High

577906

PLAK
Junction plakoglobin

1

4

High-throughput

0.536

High

615243

IL1RA
Interleukin-1 receptor antagonist protein

1

2

High-throughput

0.536

High

652424

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

711745

RABP2
Cellular retinoic acid-binding protein 2

1

1

High-throughput

0.536

High

713467

SPB3
Serpin B3

1

6

High-throughput

0.536

High

724643

S10A7
Protein S100-A7

1

1

High-throughput

0.536

High

787716

SPB5
Serpin B5

1

6

High-throughput

0.536

High

818773

CAPG
Macrophage-capping protein

1

2

High-throughput

0.536

High

868778

LEG7
Galectin-7

1

1

High-throughput

0.536

High

874877

SPB4
Serpin B4

1

6

High-throughput

0.536

High

931305

AT12A
Potassium-transporting ATPase alpha chain 2

1

1

High-throughput

0.536

High

945871

EPIPL
Epiplakin

1

3

High-throughput

0.536

High

1286357

S1A7A
Protein S100-A7A

1

1

High-throughput

0.536

High

1338075

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.536

High

1353466

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

2

High-throughput

0.536

High

1369019

EVPL
Envoplakin

1

7

High-throughput

0.536

High

1396693

CPNS2
Calpain small subunit 2

1

6

High-throughput

0.536

High

1450767

IL36G
Interleukin-36 gamma

1

2

High-throughput

0.536

High

1450768

CALL5
Calmodulin-like protein 5

1

1

High-throughput

0.536

High

1450771

SPB13
Serpin B13

1

6

High-throughput

0.536

High

1450774

TRI35
E3 ubiquitin-protein ligase TRIM35

1

4

High-throughput

0.536

High

582630

PPAP
Prostatic acid phosphatase

1

0

High-throughput

0.513

High

609340

SAP3
Ganglioside GM2 activator

1

0

High-throughput

0.513

High

627170

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.513

High

636187

ENDOU
Uridylate-specific endoribonuclease

1

0

High-throughput

0.513

High

692822

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

1400659

GSDMA
Gasdermin-A

1

0

High-throughput

0.513

High

1410004

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.513

High

1450773

NDRG2
Protein NDRG2

1

0

High-throughput

0.513

High

261665

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

369512

AACT
Alpha-1-antichymotrypsin

1

5

High-throughput

0.489

High

721533

ILEU
Leukocyte elastase inhibitor

1

6

High-throughput

0.489

High

888571

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

892141

KLK7
Kallikrein-7

1

2

High-throughput

0.489

High

1009733

NGAL
Neutrophil gelatinase-associated lipocalin

1

2

High-throughput

0.489

High

1120974

TRI29
Tripartite motif-containing protein 29

1

10

High-throughput

0.489

High

1358588

POF1B
Protein POF1B

1

1

High-throughput

0.489

High

704557

RXRB
Retinoic acid receptor RXR-beta

1

3

High-throughput

0.479

High

1135827

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

1280548

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1308594

NUDC3
NudC domain-containing protein 3

1

20

High-throughput

0.479

High

1348538

LNX1
E3 ubiquitin-protein ligase LNX

1

10

Small-scale

0.479

High

1434033

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

291562

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

58949

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

1

High-throughput

0.445

High

128329

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

11

High-throughput

0.445

High

700484

PSB8
Proteasome subunit beta type-8

1

1

High-throughput

0.445

High

1290990

TAXB1
Tax1-binding protein 1

1

8

High-throughput

0.445

High

1404121

PSB7
Proteasome subunit beta type-7

1

1

High-throughput

0.445

High

1412791

UBAC1
Ubiquitin-associated domain-containing protein 1

1

2

High-throughput

0.445

High

75733

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

1325768

LNX2
Ligand of Numb protein X 2

1

10

Small-scale

0.437

High

69560

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

1233895

K0930
Uncharacterized protein KIAA0930

3

0

High-throughput

0.347

High

1314616

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.316

High

1154354

CYTM
Cystatin-M

1

0

High-throughput

0.279

Low

1236044

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

1249639

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.279

Low

1396516

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

1450766

RBAK
RB-associated KRAB zinc finger protein

1

0

High-throughput

0.279

Low

1450770

CBPA4
Carboxypeptidase A4

1

0

High-throughput

0.279

Low

1450772

CLC4K
C-type lectin domain family 4 member K

1

0

High-throughput

0.279

Low

218843

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025