Protein: APH1A
Gamma-secretase subunit APH-1A (APH-1a) (Aph-1alpha) (Presenilin-stabilization factor)

Gene: APH1A
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q96BI3

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001656 - metanephros development
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

890031

PSN1
Presenilin-1

7

10

Small-scale

0.961

High

890765

PSN2
Presenilin-2

3

10

Small-scale

0.839

High

1364051

NICA
Nicastrin

10

6

Small-scale

0.751

High

1384650

PEN2
Gamma-secretase subunit PEN-2

7

3

Small-scale

0.740

High

1384644

FXYD6
FXYD domain-containing ion transport regulator 6

2

1

High-throughput

0.606

High

1384647

S39A9
Zinc transporter ZIP9

2

1

High-throughput

0.606

High

60594

TM218
Transmembrane protein 218

2

0

High-throughput

0.580

High

220400

LAT
Linker for activation of T-cells family member 1

2

0

High-throughput

0.580

High

423823

APOD
Apolipoprotein D

2

0

High-throughput

0.580

High

455930

ASGR1
Asialoglycoprotein receptor 1

2

0

High-throughput

0.580

High

1023965

EM55
55 kDa erythrocyte membrane protein

2

0

High-throughput

0.580

High

1081324

SMAGP
Small cell adhesion glycoprotein

2

0

High-throughput

0.580

High

1254186

MFSD6
Major facilitator superfamily domain-containing protein 6

2

0

High-throughput

0.580

High

1292124

ANR46
Ankyrin repeat domain-containing protein 46

2

0

High-throughput

0.580

High

1384643

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

High-throughput

0.580

High

1384648

TM140
Transmembrane protein 140

2

0

High-throughput

0.580

High

1384649

S38A7
Sodium-coupled neutral amino acid transporter 7

2

0

High-throughput

0.580

High

1384652

FIS1
Mitochondrial fission 1 protein

2

0

High-throughput

0.580

High

1384653

SERP1
Stress-associated endoplasmic reticulum protein 1

2

0

High-throughput

0.580

High

846088

GLP1R
Glucagon-like peptide 1 receptor

1

1

Small-scale

0.552

High

1242896

S39A4
Zinc transporter ZIP4

1

1

High-throughput

0.536

High

1384645

SNX25
Sorting nexin-25

1

1

High-throughput

0.536

High

572458

DRD2
D(2) dopamine receptor

1

0

High-throughput

0.518

High

1384646

GPR35
G-protein coupled receptor 35

1

0

High-throughput

0.518

High

63685

A5PKU2
TUSC5 protein

1

3

High-throughput

0.515

High

422823

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

1331184

F241A
Uncharacterized protein FAM241A

1

0

High-throughput

0.513

High

440668

FYN
Tyrosine-protein kinase Fyn

1

0

High-throughput

0.493

High

958170

ARP3
Actin-related protein 3

1

0

High-throughput

0.493

High

1149058

CYH1
Cytohesin-1

1

0

High-throughput

0.493

High

1364080

SNX19
Sorting nexin-19

1

1

High-throughput

0.489

High

230388

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.486

High

1126801

HES1
Transcription factor HES-1

1

1

High-throughput

0.481

High

1312112

TARG1
Trafficking regulator of GLUT4 1

1

3

High-throughput

0.481

High

321328

ERLN2
Erlin-2

1

1

Small-scale

0.479

High

1249093

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1384642

APH1A
Gamma-secretase subunit APH-1A

1

0

Small-scale

0.458

High

733039

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.445

High

155016

BHE40
Class E basic helix-loop-helix protein 40

1

1

High-throughput

0.439

High

1047851

TLE1
Transducin-like enhancer protein 1

1

2

High-throughput

0.439

High

1330725

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.426

High

1351516

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.426

High

666012

IBP5
Insulin-like growth factor-binding protein 5

2

0

High-throughput

0.316

High

944203

SCND1
SCAN domain-containing protein 1

2

0

High-throughput

0.316

High

617235

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

High-throughput

0.282

High

167348

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.251

Low

211383

RFOX2
RNA binding protein fox-1 homolog 2

1

0

High-throughput

0.251

Low

586337

ZEP1
Zinc finger protein 40

1

0

High-throughput

0.251

Low

821240

TPO
Thrombopoietin

1

0

High-throughput

0.251

Low

1384651

GPTC8
G patch domain-containing protein 8

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025