Protein: GREM2
Gremlin-2 (Cysteine knot superfamily 1, BMP antagonist 2) (DAN domain family member 3) (Protein related to DAN and cerberus)

Gene: GREM2
Organism: Homo sapiens
Interactions: 38
UniProt ID: Q9H772

Gene Ontology (top 5):
GO:0005125 - cytokine activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0008201 - heparin binding
GO:0010172 - embryonic body morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

207881

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

2

1

High-throughput

0.549

High

1212618

HECD3
E3 ubiquitin-protein ligase HECTD3

2

1

High-throughput

0.549

High

1358858

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

1

High-throughput

0.549

High

370114

CYTS
Cystatin-S

1

1

High-throughput

0.536

High

370235

CYTN
Cystatin-SN

1

1

High-throughput

0.536

High

541685

FGFR1
Fibroblast growth factor receptor 1

1

2

High-throughput

0.536

High

772340

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

4

High-throughput

0.536

High

1047739

NOTC2
Neurogenic locus notch homolog protein 2

1

1

High-throughput

0.536

High

1324225

VWDE
von Willebrand factor D and EGF domain-containing protein

1

1

High-throughput

0.536

High

1366668

SORL
Sortilin-related receptor

1

2

High-throughput

0.536

High

562760

BMP1
Bone morphogenetic protein 1

1

0

High-throughput

0.513

High

719742

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

0

High-throughput

0.513

High

1158184

MK14
Mitogen-activated protein kinase 14

1

0

High-throughput

0.513

High

376548

LDLR
Low-density lipoprotein receptor

1

2

High-throughput

0.489

High

1022647

LRP2
Low-density lipoprotein receptor-related protein 2

1

2

High-throughput

0.489

High

1290304

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

1

High-throughput

0.489

High

1401282

NACC1
Nucleus accumbens-associated protein 1

1

1

High-throughput

0.489

High

291961

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

0

High-throughput

0.279

Low

835755

KPCI
Protein kinase C iota type

1

0

High-throughput

0.279

Low

994377

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

High-throughput

0.279

Low

1108159

SQSTM
Sequestosome-1

1

0

High-throughput

0.279

Low

1220801

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.279

Low

1272747

MAEA
E3 ubiquitin-protein transferase MAEA

1

0

High-throughput

0.279

Low

1279236

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.279

Low

1311109

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.279

Low

1333078

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

0

High-throughput

0.279

Low

1382776

FERM2
Fermitin family homolog 2

1

0

High-throughput

0.279

Low

1388498

ZMY19
Zinc finger MYND domain-containing protein 19

1

0

High-throughput

0.279

Low

1393316

SAHH3
Adenosylhomocysteinase 3

1

0

High-throughput

0.279

Low

1396810

SNX27
Sorting nexin-27

1

0

High-throughput

0.279

Low

1412786

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

High-throughput

0.279

Low

1435552

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.279

Low

1435554

MKLN1
Muskelin

1

0

High-throughput

0.279

Low

1361394

BBX
HMG box transcription factor BBX

1

0

High-throughput

0.232

Low

1434743

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.232

Low

1434910

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

0

High-throughput

0.232

Low

1435551

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.232

Low

1435553

AHSP
Alpha-hemoglobin-stabilizing protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025