Protein: KI2L4
Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d)

Gene: KI2L4, KIR2DL4
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q99706

Gene Ontology (top 5):
GO:0002729 - positive regulation of natural killer cell cytokine production
GO:0002764 - immune response-regulating signaling pathway
GO:0004888 - transmembrane signaling receptor activity
GO:0005886 - plasma membrane
GO:0006968 - cellular defense response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607412

HLAG
HLA class I histocompatibility antigen, alpha chain G

2

20

Small-scale

0.768

High

1228648

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

12

High-throughput

0.691

High

473506

FCG3A
Low affinity immunoglobulin gamma Fc region receptor III-A

1

9

Small-scale

0.618

High

718725

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

2

5

Small-scale

0.584

High

1151631

TRIP6
Thyroid receptor-interacting protein 6

1

5

High-throughput

0.573

High

1216151

FHL5
Four and a half LIM domains protein 5

2

4

High-throughput

0.553

High

1406548

BPIA1
BPI fold-containing family A member 1

2

1

High-throughput

0.553

High

163350

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

6

High-throughput

0.536

High

169726

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

18

High-throughput

0.536

High

189264

IPO8
Importin-8

1

4

High-throughput

0.536

High

222391

TSN6
Tetraspanin-6

1

5

High-throughput

0.536

High

334888

IPO7
Importin-7

1

5

High-throughput

0.536

High

565693

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

1

High-throughput

0.536

High

591356

CD44
CD44 antigen

1

3

High-throughput

0.536

High

661323

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

9

High-throughput

0.536

High

931286

AT12A
Potassium-transporting ATPase alpha chain 2

1

1

High-throughput

0.536

High

1008305

PRKDC
DNA-dependent protein kinase catalytic subunit

1

2

High-throughput

0.536

High

1032645

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

8

High-throughput

0.536

High

1037032

DSC2
Desmocollin-2

1

10

High-throughput

0.536

High

1140742

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.536

High

1154721

VAMP3
Vesicle-associated membrane protein 3

1

3

High-throughput

0.536

High

1203778

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1226419

TBC9B
TBC1 domain family member 9B

1

5

High-throughput

0.536

High

1245121

RHDF2
Inactive rhomboid protein 2

1

3

High-throughput

0.536

High

1251742

CERS6
Ceramide synthase 6

1

1

High-throughput

0.536

High

1290525

LAP4B
Lysosomal-associated transmembrane protein 4B

1

2

High-throughput

0.536

High

1346765

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

2

High-throughput

0.536

High

1349684

CIP2A
Protein CIP2A

1

2

High-throughput

0.536

High

1365120

SL9A6
Sodium/hydrogen exchanger 6

1

1

High-throughput

0.536

High

1381818

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

2

High-throughput

0.536

High

1402458

MYADM
Myeloid-associated differentiation marker

1

3

High-throughput

0.536

High

1406541

PKP2
Plakophilin-2

1

6

High-throughput

0.536

High

1406547

AT131
Endoplasmic reticulum transmembrane helix translocase

1

3

High-throughput

0.536

High

1406551

GINM1
Glycoprotein integral membrane protein 1

1

1

High-throughput

0.536

High

1406556

LRP12
Low-density lipoprotein receptor-related protein 12

1

1

High-throughput

0.536

High

1406558

MTCH2
Mitochondrial carrier homolog 2

1

3

High-throughput

0.536

High

178833

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.513

High

211841

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.513

High

256122

S19A2
Thiamine transporter 1

1

0

High-throughput

0.513

High

376538

LDLR
Low-density lipoprotein receptor

1

0

High-throughput

0.513

High

582397

B4GT1
Beta-1,4-galactosyltransferase 1

1

0

High-throughput

0.513

High

749266

CD70
CD70 antigen

1

0

High-throughput

0.513

High

790173

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

High-throughput

0.513

High

1312166

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.513

High

1325380

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.513

High

1350112

SPP2A
Signal peptide peptidase-like 2A

1

0

High-throughput

0.513

High

1356598

CHPT1
Cholinephosphotransferase 1

1

0

High-throughput

0.513

High

1358466

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.513

High

1390780

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.513

High

1392711

S39AD
Zinc transporter ZIP13

1

0

High-throughput

0.513

High

1396207

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.513

High

1401072

XPO6
Exportin-6

1

0

High-throughput

0.513

High

1406542

G6PC3
Glucose-6-phosphatase 3

1

0

High-throughput

0.513

High

1406544

YIPF3
Protein YIPF3

1

0

High-throughput

0.513

High

1406545

INT2
Integrator complex subunit 2

1

0

High-throughput

0.513

High

1406546

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

164631

TNPO2
Transportin-2

1

5

High-throughput

0.489

High

220973

XPOT
Exportin-T

1

7

High-throughput

0.489

High

249892

STX10
Syntaxin-10

1

3

High-throughput

0.489

High

252905

EXOC3
Exocyst complex component 3

1

1

High-throughput

0.489

High

298952

DNJB5
DnaJ homolog subfamily B member 5

1

3

High-throughput

0.489

High

317912

LTN1
E3 ubiquitin-protein ligase listerin

1

1

High-throughput

0.489

High

322757

RHBT3
Rho-related BTB domain-containing protein 3

1

4

High-throughput

0.489

High

946191

MLF1
Myeloid leukemia factor 1

1

1

High-throughput

0.489

High

1053733

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.489

High

1200278

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

3

High-throughput

0.489

High

1237919

PHLB3
Pleckstrin homology-like domain family B member 3

1

3

High-throughput

0.489

High

1239540

ZNT6
Zinc transporter 6

1

2

High-throughput

0.489

High

1248285

MOXD1
DBH-like monooxygenase protein 1

1

1

High-throughput

0.489

High

1254232

TBCD9
TBC1 domain family member 9

1

6

High-throughput

0.489

High

1363558

FAM3C
Protein FAM3C

1

2

High-throughput

0.489

High

1371183

GLMN
Glomulin

1

2

High-throughput

0.489

High

1402140

JMJD8
JmjC domain-containing protein 8

1

1

High-throughput

0.489

High

1406543

XPO4
Exportin-4

1

3

High-throughput

0.489

High

1406554

TMED7
Transmembrane emp24 domain-containing protein 7

1

1

High-throughput

0.489

High

1406557

TNPO3
Transportin-3

1

10

High-throughput

0.489

High

1406555

TRAF6
TNF receptor-associated factor 6

1

5

Small-scale

0.479

High

465029

SP1
Transcription factor Sp1

1

2

Small-scale

0.437

High

506651

GPHRB
Golgi pH regulator B

1

1

High-throughput

0.437

High

577495

ETS1
Protein C-ets-1

1

2

Small-scale

0.437

High

613157

EGR1
Early growth response protein 1

1

3

High-throughput

0.437

High

1029920

RUNX1
Runt-related transcription factor 1

1

3

Small-scale

0.437

High

1117066

RUNX3
Runt-related transcription factor 3

1

3

Small-scale

0.437

High

85395

GPHRA
Golgi pH regulator A

1

1

High-throughput

0.407

High

1081451

INCA1
Protein INCA1

2

0

High-throughput

0.316

High

1406549

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

2

0

High-throughput

0.316

High

1406552

RN216
E3 ubiquitin-protein ligase RNF216

1

0

Small-scale

0.299

High

1372049

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.299

High

325588

YIF1A
Protein YIF1A

1

0

High-throughput

0.279

Low

407884

SEMG1
Semenogelin-1

1

0

High-throughput

0.279

Low

1229195

INT3
Integrator complex subunit 3

1

0

High-throughput

0.279

Low

1238586

RINT1
RAD50-interacting protein 1

1

0

High-throughput

0.279

Low

1275959

SETX
Probable helicase senataxin

1

0

High-throughput

0.279

Low

1325275

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.279

Low

1360064

NELFB
Negative elongation factor B

1

0

High-throughput

0.279

Low

1389647

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.279

Low

1393573

INT4
Integrator complex subunit 4

1

0

High-throughput

0.279

Low

1406550

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.279

Low

1406553

DOLK
Dolichol kinase

1

0

High-throughput

0.279

Low

511044

PNM6A
Paraneoplastic antigen-like protein 6A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025