Protein: DZIP3
E3 ubiquitin-protein ligase DZIP3 (EC 2.3.2.27) (DAZ-interacting protein 3) (RING-type E3 ubiquitin transferase DZIP3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138)

Gene: DZIP3
Organism: Homo sapiens
Interactions: 177
UniProt ID: Q86Y13

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0003723 - RNA binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1294552

UB2E2
Ubiquitin-conjugating enzyme E2 E2

4

20

High-throughput

0.885

High

906698

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.800

High

982234

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.800

High

1294533

DZIP3
E3 ubiquitin-protein ligase DZIP3

2

18

Small-scale

0.778

High

1294562

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

4

10

High-throughput

0.705

High

909343

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

957127

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.698

High

957782

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

970731

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

993641

UBC9
SUMO-conjugating enzyme UBC9

1

20

High-throughput

0.698

High

1103913

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

1154273

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.698

High

1218728

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1258770

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

20

High-throughput

0.698

High

1294545

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

1294546

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1294567

RNF38
E3 ubiquitin-protein ligase RNF38

1

12

High-throughput

0.698

High

1294597

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

927395

ATX1
Ataxin-1

3

2

Small-scale

0.676

High

912950

HNRPF
Heterogeneous nuclear ribonucleoprotein F

3

9

High-throughput

0.675

High

600331

ZNF24
Zinc finger protein 24

3

5

High-throughput

0.664

High

1294539

ZCH10
Zinc finger CCHC domain-containing protein 10

3

1

High-throughput

0.664

High

1029008

TIAR
Nucleolysin TIAR

3

3

High-throughput

0.657

High

1294561

RBM4B
RNA-binding protein 4B

2

10

High-throughput

0.628

High

1294570

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.625

High

1294571

AKTIP
AKT-interacting protein

1

20

High-throughput

0.625

High

1293366

CARM1
Histone-arginine methyltransferase CARM1

2

4

Small-scale

0.624

High

957624

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

20

High-throughput

0.621

High

1294581

RN181
E3 ubiquitin-protein ligase RNF181

1

11

High-throughput

0.618

High

1294598

RNF11
RING finger protein 11

1

15

Small-scale

0.618

High

336710

BAG4
BAG family molecular chaperone regulator 4

2

6

High-throughput

0.606

High

729341

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

9

High-throughput

0.606

High

1005610

PITX1
Pituitary homeobox 1

2

3

High-throughput

0.606

High

1224846

TENS2
Tensin-2

2

5

High-throughput

0.606

High

414143

P53
Cellular tumor antigen p53

2

11

Small-scale

0.595

High

1294566

TOLIP
Toll-interacting protein

1

3

High-throughput

0.586

High

1109860

HDAC1
Histone deacetylase 1

2

16

Small-scale

0.584

High

1294547

PF21A
PHD finger protein 21A

2

8

Small-scale

0.584

High

1294548

FBX17
F-box only protein 17

2

0

High-throughput

0.580

High

1294577

MED4
Mediator of RNA polymerase II transcription subunit 4

2

1

High-throughput

0.574

High

664772

CCND1
G1/S-specific cyclin-D1

1

3

Small-scale

0.561

High

725084

HXC8
Homeobox protein Hox-C8

2

2

High-throughput

0.553

High

1240793

T2H2L
General transcription factor IIH subunit 2-like protein

1

0

High-throughput

0.549

High

1271961

ZN765
Zinc finger protein 765

1

0

High-throughput

0.549

High

623417

RO52
E3 ubiquitin-protein ligase TRIM21

1

10

High-throughput

0.541

High

1106997

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.541

High

1107425

BIRC2
Baculoviral IAP repeat-containing protein 2

1

7

High-throughput

0.541

High

1185917

PCGF3
Polycomb group RING finger protein 3

1

11

High-throughput

0.541

High

1294580

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.541

High

74536

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

6

High-throughput

0.536

High

1126716

BECN1
Beclin-1

1

1

High-throughput

0.536

High

75515

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

419063

H2A1B
Histone H2A type 1-B/E

1

2

Small-scale

0.528

High

67688

RHG32
Rho GTPase-activating protein 32

1

7

High-throughput

0.523

High

1294553

CEP63
Centrosomal protein of 63 kDa

1

18

High-throughput

0.523

High

1294563

AP1M1
AP-1 complex subunit mu-1

1

3

High-throughput

0.523

High

1254251

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.518

High

1294560

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.518

High

846372

MATR3
Matrin-3

1

5

High-throughput

0.515

High

1294599

GRIP1
Glutamate receptor-interacting protein 1

1

7

Small-scale

0.512

High

1294578

DAZ1
Deleted in azoospermia protein 1

1

11

Small-scale

0.508

High

967837

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

12

Small-scale

0.501

High

256480

TOM1
Target of Myb1 membrane trafficking protein

1

11

High-throughput

0.479

High

316904

MTA2
Metastasis-associated protein MTA2

1

5

Small-scale

0.479

High

442760

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.479

High

460587

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.479

High

474796

VIME
Vimentin

1

20

Small-scale

0.479

High

573855

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.479

High

655260

SFPQ
Splicing factor, proline- and glutamine-rich

1

8

Small-scale

0.479

High

675570

TYY1
Transcriptional repressor protein YY1

1

2

Small-scale

0.479

High

713808

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

7

High-throughput

0.479

High

875709

PRC2A
Protein PRRC2A

1

16

High-throughput

0.479

High

964666

DCAF7
DDB1- and CUL4-associated factor 7

1

14

Small-scale

0.479

High

1008221

PRKDC
DNA-dependent protein kinase catalytic subunit

1

7

Small-scale

0.479

High

1014547

SMAD3
Mothers against decapentaplegic homolog 3

1

3

Small-scale

0.479

High

1100087

TIF1B
Transcription intermediary factor 1-beta

1

13

Small-scale

0.479

High

1102585

MTA1
Metastasis-associated protein MTA1

1

5

Small-scale

0.479

High

1112585

CUL1
Cullin-1

1

15

Small-scale

0.479

High

1115285

CUL4B
Cullin-4B

1

15

Small-scale

0.479

High

1117056

RUNX3
Runt-related transcription factor 3

1

1

Small-scale

0.479

High

1122415

GIT2
ARF GTPase-activating protein GIT2

1

10

High-throughput

0.479

High

1129442

PUM1
Pumilio homolog 1

1

2

High-throughput

0.479

High

1130095

SMC1A
Structural maintenance of chromosomes protein 1A

1

13

Small-scale

0.479

High

1132805

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

Small-scale

0.479

High

1144402

NONO
Non-POU domain-containing octamer-binding protein

1

10

Small-scale

0.479

High

1153974

SMAD1
Mothers against decapentaplegic homolog 1

1

3

Small-scale

0.479

High

1158905

RBBP7
Histone-binding protein RBBP7

1

15

Small-scale

0.479

High

1165464

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

5

High-throughput

0.479

High

1239864

CAVN1
Caveolae-associated protein 1

1

1

High-throughput

0.479

High

1252325

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

1280684

YTHD3
YTH domain-containing family protein 3

1

10

High-throughput

0.479

High

1294534

P66A
Transcriptional repressor p66-alpha

1

1

Small-scale

0.479

High

1294535

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

19

High-throughput

0.479

High

1294536

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

High-throughput

0.479

High

1294538

LNX1
E3 ubiquitin-protein ligase LNX

1

7

Small-scale

0.479

High

1294541

GEMI5
Gem-associated protein 5

1

9

Small-scale

0.479

High

1294542

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

1294543

FUBP2
Far upstream element-binding protein 2

1

8

High-throughput

0.479

High

1294544

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

2

Small-scale

0.479

High

1294550

FUBP3
Far upstream element-binding protein 3

1

8

High-throughput

0.479

High

1294555

RBM14
RNA-binding protein 14

1

9

Small-scale

0.479

High

1294556

WRIP1
ATPase WRNIP1

1

2

High-throughput

0.479

High

1294557

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

1294558

CDC5L
Cell division cycle 5-like protein

1

2

Small-scale

0.479

High

1294559

ATX2
Ataxin-2

1

8

High-throughput

0.479

High

1294564

YTHD1
YTH domain-containing family protein 1

1

10

High-throughput

0.479

High

1294568

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

6

Small-scale

0.479

High

1294569

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.479

High

1294572

MOV10
Helicase MOV-10

1

2

High-throughput

0.479

High

1294573

NCK5L
Nck-associated protein 5-like

1

2

High-throughput

0.479

High

1294575

TUFT1
Tuftelin

1

2

High-throughput

0.479

High

1294579

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

9

Small-scale

0.479

High

1294582

ZMYM2
Zinc finger MYM-type protein 2

1

1

High-throughput

0.479

High

1294583

LIMD1
LIM domain-containing protein 1

1

11

Small-scale

0.479

High

1294584

XPO7
Exportin-7

1

4

High-throughput

0.479

High

1294586

HERC5
E3 ISG15--protein ligase HERC5

1

13

Small-scale

0.479

High

1294587

RABX5
Rab5 GDP/GTP exchange factor

1

3

High-throughput

0.479

High

1294591

MYO6
Unconventional myosin-VI

1

19

High-throughput

0.479

High

1294594

RUVB2
RuvB-like 2

1

5

Small-scale

0.479

High

1294596

R3HD2
R3H domain-containing protein 2

1

4

High-throughput

0.479

High

1294600

YTHD2
YTH domain-containing family protein 2

1

10

High-throughput

0.479

High

1294601

NS1BP
Influenza virus NS1A-binding protein

1

7

Small-scale

0.479

High

1117406

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.470

High

128451

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.458

High

163131

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.458

High

503620

TFPT
TCF3 fusion partner

1

0

High-throughput

0.458

High

719346

MPIP3
M-phase inducer phosphatase 3

1

0

Small-scale

0.458

High

1157797

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

1294549

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.458

High

1294574

BRMS1
Breast cancer metastasis-suppressor 1

1

0

Small-scale

0.458

High

1029871

RUNX1
Runt-related transcription factor 1

1

1

Small-scale

0.457

High

1294588

TNIK
TRAF2 and NCK-interacting protein kinase

1

20

High-throughput

0.457

High

1288891

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

11

High-throughput

0.445

High

130773

TAF4
Transcription initiation factor TFIID subunit 4

1

5

Small-scale

0.437

High

132744

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

10

High-throughput

0.437

High

163997

NDC80
Kinetochore protein NDC80 homolog

1

18

High-throughput

0.437

High

192938

CLOCK
Circadian locomoter output cycles protein kaput

1

10

High-throughput

0.437

High

246728

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.437

High

278378

NCOR1
Nuclear receptor corepressor 1

1

16

Small-scale

0.437

High

469304

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

4

Small-scale

0.437

High

634511

LMNB1
Lamin-B1

1

18

Small-scale

0.437

High

703343

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

7

Small-scale

0.437

High

846631

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.437

High

941481

CTBP2
C-terminal-binding protein 2

1

3

Small-scale

0.437

High

959611

MAX
Protein max

1

6

High-throughput

0.437

High

997832

CSK21
Casein kinase II subunit alpha

1

14

Small-scale

0.437

High

1048026

TLE3
Transducin-like enhancer protein 3

1

14

Small-scale

0.437

High

1066376

RBBP4
Histone-binding protein RBBP4

1

10

Small-scale

0.437

High

1103260

CTBP1
C-terminal-binding protein 1

1

3

Small-scale

0.437

High

1144843

RABE1
Rab GTPase-binding effector protein 1

1

17

High-throughput

0.437

High

1149780

TAF5
Transcription initiation factor TFIID subunit 5

1

10

Small-scale

0.437

High

1163032

H2B2E
Histone H2B type 2-E

1

12

Small-scale

0.437

High

1196275

GRAP1
GRIP1-associated protein 1

1

18

High-throughput

0.437

High

1200043

EIPR1
EARP and GARP complex-interacting protein 1

1

10

High-throughput

0.437

High

1201133

CCD93
Coiled-coil domain-containing protein 93

1

14

High-throughput

0.437

High

1237902

PHLB3
Pleckstrin homology-like domain family B member 3

1

17

High-throughput

0.437

High

1243014

PKN3
Serine/threonine-protein kinase N3

1

14

High-throughput

0.437

High

1256888

TM1L2
TOM1-like protein 2

1

11

High-throughput

0.437

High

1278402

HAUS6
HAUS augmin-like complex subunit 6

1

2

High-throughput

0.437

High

1294537

GOGA5
Golgin subfamily A member 5

1

18

High-throughput

0.437

High

1294540

CCHCR
Coiled-coil alpha-helical rod protein 1

1

14

High-throughput

0.437

High

1294565

NUF2
Kinetochore protein Nuf2

1

18

High-throughput

0.437

High

1294576

HM20A
High mobility group protein 20A

1

6

High-throughput

0.437

High

1294589

RCOR1
REST corepressor 1

1

7

High-throughput

0.437

High

1294592

MAGD2
Melanoma-associated antigen D2

1

16

Small-scale

0.437

High

1294593

SMC3
Structural maintenance of chromosomes protein 3

1

13

Small-scale

0.437

High

1294595

RUVB1
RuvB-like 1

1

5

Small-scale

0.437

High

1133787

SL9A5
Sodium/hydrogen exchanger 5

1

5

High-throughput

0.407

High

85283

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

217143

MS18B
Protein Mis18-beta

1

0

High-throughput

0.249

Low

340358

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.249

Low

1217263

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.249

Low

1294551

VPS50
Syndetin

1

0

High-throughput

0.249

Low

1294554

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.249

Low

1294585

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.249

Low

1294590

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025