Protein: HXKG
Glucokinase-1 (EC 2.7.1.2) (Glucose kinase 1) (GLK-1)

Gene: HXKG, GLK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 97
UniProt ID: P17709

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0004340 - glucokinase activity
GO:0005524 - ATP binding
GO:0005536 - D-glucose binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607728

HXKG
Glucokinase-1

2

14

Small-scale

0.786

High

607787

EMI2
Putative glucokinase-2

2

14

High-throughput

0.743

High

607739

HS104
Heat shock protein 104

2

5

Small-scale

0.584

High

607771

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

543739

SSB1
Ribosome-associated molecular chaperone SSB1

2

11

High-throughput

0.571

High

607731

SIS1
Protein SIS1

2

5

High-throughput

0.571

High

558567

CAF20
Cap-associated protein CAF20

2

2

High-throughput

0.543

High

607791

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

2

1

High-throughput

0.543

High

607783

IMA1
Importin subunit alpha

1

1

High-throughput

0.541

High

460943

LTE1
Guanine nucleotide exchange factor LTE1

1

1

High-throughput

0.536

High

509383

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

607768

BNI1
Protein BNI1

1

1

High-throughput

0.501

High

364317

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.500

High

416794

DNLI1
DNA ligase 1

1

1

High-throughput

0.500

High

607737

HRR25
Casein kinase I homolog HRR25

1

2

High-throughput

0.500

High

607738

RAD16
DNA repair protein RAD16

1

3

High-throughput

0.500

High

607742

GYP6
GTPase-activating protein GYP6

1

1

High-throughput

0.500

High

607748

TCTP
Translationally-controlled tumor protein homolog

1

2

High-throughput

0.500

High

607749

YPT10
GTP-binding protein YPT10

1

4

High-throughput

0.500

High

607754

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

4

High-throughput

0.500

High

607755

RCK1
Serine/threonine-protein kinase RCK1

1

4

High-throughput

0.500

High

607762

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.500

High

607763

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

2

High-throughput

0.500

High

607766

TBP6
Probable 26S proteasome subunit YTA6

1

6

High-throughput

0.500

High

607773

PPP5
Serine/threonine-protein phosphatase T

1

6

High-throughput

0.500

High

607776

SIW14
Inositol diphosphatase SIW14

1

2

High-throughput

0.500

High

607781

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

3

High-throughput

0.500

High

607788

KU80
ATP-dependent DNA helicase II subunit 2

1

1

High-throughput

0.500

High

607796

MLH3
DNA mismatch repair protein MLH3

1

1

High-throughput

0.500

High

607799

YP150
Putative serine/threonine-protein kinase YPL150W

1

1

High-throughput

0.500

High

607801

ATG5
Autophagy protein 5

1

2

High-throughput

0.500

High

607741

TOR2
Serine/threonine-protein kinase TOR2

1

1

High-throughput

0.481

High

607747

TOR1
Serine/threonine-protein kinase TOR1

1

1

High-throughput

0.481

High

607757

KOG1
Target of rapamycin complex 1 subunit KOG1

1

1

High-throughput

0.481

High

444825

SIR3
Regulatory protein SIR3

1

0

High-throughput

0.479

High

449390

SPT2
Protein SPT2

1

0

High-throughput

0.479

High

557659

SRS2
ATP-dependent DNA helicase SRS2

1

0

High-throughput

0.479

High

607745

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.479

High

607760

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.479

High

607767

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.479

High

607786

POLH
DNA polymerase eta

1

0

High-throughput

0.479

High

364914

KPYK1
Pyruvate kinase 1

1

2

Small-scale

0.479

High

392189

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

578796

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

607730

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.479

High

607734

CDC48
Cell division control protein 48

1

4

High-throughput

0.479

High

607743

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

607744

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.479

High

607758

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

607764

RSP5
E3 ubiquitin-protein ligase RSP5

1

2

High-throughput

0.479

High

607772

KPYK2
Pyruvate kinase 2

1

2

High-throughput

0.479

High

607777

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

607797

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

607802

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.479

High

607782

MCE1
mRNA-capping enzyme subunit alpha

1

0

High-throughput

0.458

High

607785

ESP1
Separin

1

0

High-throughput

0.458

High

607778

ACT
Actin

1

1

Small-scale

0.457

High

427126

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.457

High

448128

HAP2
Transcriptional activator HAP2

1

1

High-throughput

0.457

High

586424

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.457

High

607729

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.457

High

607732

CDC10
Cell division control protein 10

1

2

High-throughput

0.457

High

607735

RFA3
Replication factor A protein 3

1

1

High-throughput

0.457

High

607740

PP12
Serine/threonine-protein phosphatase PP1-2

1

4

High-throughput

0.457

High

607746

PPZ2
Serine/threonine-protein phosphatase PP-Z2

1

4

High-throughput

0.457

High

607751

PLPHP
Pyridoxal phosphate homeostasis protein

1

1

High-throughput

0.457

High

607753

SHE3
SWI5-dependent HO expression protein 3

1

1

High-throughput

0.457

High

607759

TEM1
Protein TEM1

1

4

High-throughput

0.457

High

607761

SWD1
COMPASS component SWD1

1

3

High-throughput

0.457

High

607769

SKP2
F-box protein SKP2

1

1

High-throughput

0.457

High

607770

MOB2
CBK1 kinase activator protein MOB2

1

1

High-throughput

0.457

High

607775

CWC22
Pre-mRNA-splicing factor CWC22

1

1

High-throughput

0.457

High

607779

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.457

High

607790

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.457

High

607800

RAD59
DNA repair protein RAD59

1

1

High-throughput

0.457

High

522984

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.445

High

525857

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

607765

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

607793

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

3

High-throughput

0.445

High

607736

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

607750

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

607756

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.437

High

607795

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

607798

RRP6
Exosome complex exonuclease RRP6

1

5

High-throughput

0.437

High

454391

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.279

Low

381852

H4
Histone H4

1

0

High-throughput

0.269

Low

607780

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.269

Low

607803

NOP58
Nucleolar protein 58

1

0

High-throughput

0.269

Low

423581

ARGR2
Arginine metabolism regulation protein II

1

0

High-throughput

0.265

Low

607752

FIG1
Factor-induced gene 1 protein

1

0

High-throughput

0.265

Low

607794

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.261

Low

607774

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.261

Low

607784

UTP17
NET1-associated nuclear protein 1

1

0

High-throughput

0.261

Low

607789

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.261

Low

607733

YCE6
Putative uncharacterized protein YCL046W

1

0

High-throughput

0.249

Low

607792

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025