Protein: UTP4
U3 small nucleolar RNA-associated protein 4 (U3 snoRNA-associated protein 4) (U three protein 4) (U3 protein 4 required for transcription) (t-UTP4)

Gene: UTP4
Organism: Saccharomyces cerevisiae S288C
Interactions: 146
UniProt ID: Q06679

Gene Ontology (top 5):
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0030490 - maturation of SSU-rRNA
GO:0030686 - 90S preribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1039862

UTP17
NET1-associated nuclear protein 1

7

20

Small-scale

0.963

High

1046261

UTP15
U3 small nucleolar RNA-associated protein 15

7

18

Small-scale

0.963

High

823396

UTP18
U3 small nucleolar RNA-associated protein 18

7

3

Small-scale

0.963

High

678470

PWP2
Periodic tryptophan protein 2

7

19

Small-scale

0.962

High

1046049

DHR1
Probable ATP-dependent RNA helicase DHR1

6

9

Small-scale

0.937

High

817642

UTP7
U3 small nucleolar RNA-associated protein 7

5

18

Small-scale

0.925

High

1055434

RRP9
Ribosomal RNA-processing protein 9

4

19

Small-scale

0.895

High

1056483

UTP4
U3 small nucleolar RNA-associated protein 4

2

18

Small-scale

0.776

High

919182

UTP8
U3 small nucleolar RNA-associated protein 8

11

1

Small-scale

0.758

High

844629

UTP10
U3 small nucleolar RNA-associated protein 10

10

6

Small-scale

0.756

High

754343

DCA13
Protein SOF1

2

18

Small-scale

0.754

High

852613

ROK1
ATP-dependent RNA helicase ROK1

2

10

Small-scale

0.754

High

864528

MTR4
ATP-dependent RNA helicase DOB1

2

20

Small-scale

0.754

High

1053118

UTP13
U3 small nucleolar RNA-associated protein 13

2

19

Small-scale

0.754

High

1045114

UTP5
U3 small nucleolar RNA-associated protein 5

8

19

Small-scale

0.749

High

1055492

NOC4
Nucleolar complex protein 4

8

7

Small-scale

0.748

High

806584

UTP9
U3 small nucleolar RNA-associated protein 9

7

1

Small-scale

0.746

High

798325

ENP1
Essential nuclear protein 1

8

2

Small-scale

0.743

High

677581

KRR1
KRR1 small subunit processome component

6

2

Small-scale

0.732

High

918836

UTP22
U3 small nucleolar RNA-associated protein 22

5

3

Small-scale

0.716

High

1056504

NOP58
Nucleolar protein 58

5

12

Small-scale

0.714

High

1053521

UTP21
U3 small nucleolar RNA-associated protein 21

5

18

Small-scale

0.709

High

1036419

UTP6
U3 small nucleolar RNA-associated protein 6

4

2

Small-scale

0.694

High

1056492

UTP16
U3 small nucleolar RNA-associated protein 16

4

1

High-throughput

0.694

High

751495

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

4

High-throughput

0.691

High

865183

MPP10
U3 small nucleolar RNA-associated protein MPP10

3

7

Small-scale

0.656

High

925206

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

3

3

Small-scale

0.656

High

1050180

RRP5
rRNA biogenesis protein RRP5

3

10

High-throughput

0.656

High

1054898

ESF1
Pre-rRNA-processing protein ESF1

3

1

High-throughput

0.654

High

673239

RRP7
Ribosomal RNA-processing protein 7

3

1

Small-scale

0.640

High

763634

UTP20
U3 small nucleolar RNA-associated protein 20

3

2

Small-scale

0.640

High

923991

CSL4
Exosome complex component CSL4

3

2

Small-scale

0.640

High

924643

NAT10
RNA cytidine acetyltransferase

3

3

Small-scale

0.640

High

1046802

UTP14
U3 small nucleolar RNA-associated protein 14

3

7

Small-scale

0.640

High

1056493

BMS1
Ribosome biogenesis protein BMS1

3

10

Small-scale

0.640

High

816181

DPO5
rDNA transcriptional regulator POL5

2

2

High-throughput

0.621

High

1030582

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

7

High-throughput

0.618

High

802911

DBP8
ATP-dependent RNA helicase DBP8

1

14

High-throughput

0.618

High

816561

SNU13
13 kDa ribonucleoprotein-associated protein

1

8

Small-scale

0.618

High

874547

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.618

High

917489

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

7

Small-scale

0.618

High

919010

PESC
Pescadillo homolog

1

2

High-throughput

0.618

High

924195

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

15

High-throughput

0.618

High

1043294

HAS1
ATP-dependent RNA helicase HAS1

1

20

High-throughput

0.618

High

1056490

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

1

Small-scale

0.618

High

1056501

DBP10
ATP-dependent RNA helicase DBP10

1

14

High-throughput

0.618

High

826219

FAF1
Protein FAF1

2

1

Small-scale

0.611

High

1056485

NOP6
Nucleolar protein 6

2

1

High-throughput

0.611

High

819906

SSB2
Ribosome-associated molecular chaperone SSB2

3

13

High-throughput

0.587

High

758416

UTP11
U3 small nucleolar RNA-associated protein 11

2

1

Small-scale

0.584

High

782112

RL1D1
Ribosome biogenesis protein UTP30

2

8

Small-scale

0.584

High

818353

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

2

1

Small-scale

0.584

High

864970

NOP9
Nucleolar protein 9

2

2

Small-scale

0.584

High

871065

NOL10
Ribosome biogenesis protein ENP2

2

4

Small-scale

0.584

High

923262

ESF2
Pre-rRNA-processing protein ESF2

2

2

Small-scale

0.584

High

1053786

SGD1
Suppressor of glycerol defect protein 1

2

3

Small-scale

0.584

High

1054544

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

2

1

Small-scale

0.584

High

1056315

BFR2
Protein BFR2

2

3

Small-scale

0.584

High

1056486

CMS1
Protein CMS1

2

1

Small-scale

0.584

High

1056487

RCL1
rRNA processing protein RCL1

2

2

Small-scale

0.584

High

1056496

SAS10
Something about silencing protein 10

2

3

Small-scale

0.584

High

1056497

RRP6
Exosome complex exonuclease RRP6

2

8

High-throughput

0.584

High

1056498

UTP12
U3 small nucleolar RNA-associated protein 12

2

18

Small-scale

0.584

High

1056505

RRP12
Ribosomal RNA-processing protein 12

2

3

Small-scale

0.584

High

1056508

NOP14
Nucleolar complex protein 14

2

4

Small-scale

0.584

High

1056509

PNO1
Pre-rRNA-processing protein PNO1

2

1

Small-scale

0.584

High

1053610

MRD1
Multiple RNA-binding domain-containing protein 1

2

5

Small-scale

0.571

High

546432

SSB1
Ribosome-associated molecular chaperone SSB1

2

13

High-throughput

0.565

High

503261

RS22A
Small ribosomal subunit protein uS8A

2

4

High-throughput

0.533

High

810771

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.514

High

525281

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.489

High

672269

CDC10
Cell division control protein 10

1

10

High-throughput

0.489

High

687617

SYLC
Leucine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.489

High

923132

BRE5
UBP3-associated protein BRE5

1

7

High-throughput

0.489

High

435384

RS3
Small ribosomal subunit protein uS3

1

6

High-throughput

0.479

High

442129

RS14A
Small ribosomal subunit protein uS11A

1

7

High-throughput

0.479

High

585390

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

9

High-throughput

0.479

High

623021

CSK22
Casein kinase II subunit alpha'

1

12

Small-scale

0.479

High

647234

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.479

High

672959

RRP43
Exosome complex component RRP43

1

1

High-throughput

0.479

High

689683

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.479

High

735184

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

747054

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

7

High-throughput

0.479

High

747598

RSSA1
Small ribosomal subunit protein uS2A

1

3

High-throughput

0.479

High

753603

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

803945

CIC1
Proteasome-interacting protein CIC1

1

8

High-throughput

0.479

High

804757

RRP4
Exosome complex component RRP4

1

6

High-throughput

0.479

High

804965

LRP1
Exosome complex protein LRP1

1

1

High-throughput

0.479

High

808318

RRP8
25S rRNA

1

3

High-throughput

0.479

High

825090

RRT14
Regulator of rDNA transcription protein 14

1

1

High-throughput

0.479

High

825570

UTP25
U3 small nucleolar RNA-associated protein 25

1

1

High-throughput

0.479

High

843278

KRI1
Protein KRI1

1

3

Small-scale

0.479

High

863143

RRP41
Exosome complex component SKI6

1

16

High-throughput

0.479

High

871132

MTR3
Exosome complex component MTR3

1

1

High-throughput

0.479

High

918902

RRP46
Exosome complex component RRP46

1

15

High-throughput

0.479

High

1042246

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.479

High

1046479

BUD22
Bud site selection protein 22

1

1

Small-scale

0.479

High

1051167

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

1051716

RRP45
Exosome complex component RRP45

1

10

High-throughput

0.479

High

1056488

RRP44
Exosome complex exonuclease DIS3

1

5

High-throughput

0.479

High

1056489

RRP40
Exosome complex component RRP40

1

2

High-throughput

0.479

High

1056495

FCF2
rRNA-processing protein FCF2

1

2

High-throughput

0.479

High

1056499

RRP42
Exosome complex component RRP42

1

10

High-throughput

0.479

High

1056500

UTP23
rRNA-processing protein UTP23

1

2

Small-scale

0.479

High

1056502

NOP56
Nucleolar protein 56

1

12

High-throughput

0.479

High

1056503

RRP36
rRNA biogenesis protein RRP36

1

1

High-throughput

0.479

High

1056506

EFG1P
rRNA-processing protein EFG1

1

1

High-throughput

0.479

High

792970

ANM1
Protein arginine N-methyltransferase 1

1

7

Small-scale

0.457

High

782458

RPF2
Ribosome biogenesis protein RPF2

1

2

High-throughput

0.445

High

430932

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

4

Small-scale

0.437

High

636690

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.437

High

708298

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

751298

BUD2
Inhibitory regulator protein BUD2/CLA2

1

7

Small-scale

0.437

High

812689

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

826871

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

918468

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.437

High

1025047

NUM1
Nuclear migration protein NUM1

1

12

High-throughput

0.437

High

1033586

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

1043924

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

1046313

VMS1
tRNA endonuclease VMS1

1

2

High-throughput

0.437

High

1056484

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

1056491

SGO1
Shugoshin

1

1

High-throughput

0.437

High

1056494

NEW1
[NU+] prion formation protein 1

1

3

Small-scale

0.437

High

1056507

RS22B
Small ribosomal subunit protein uS8B

1

4

High-throughput

0.437

High

453813

PYR1
Multifunctional protein URA2

1

6

High-throughput

0.407

High

510847

HSP77
Import motor subunit, mitochondrial

1

15

High-throughput

0.407

High

527790

HSP72
Heat shock protein SSA2

1

12

High-throughput

0.407

High

580132

HSC82
ATP-dependent molecular chaperone HSC82

1

10

High-throughput

0.407

High

671720

SCJ1
DnaJ-related protein SCJ1

1

7

High-throughput

0.407

High

676387

MAS5
Mitochondrial protein import protein MAS5

1

9

High-throughput

0.407

High

727343

HS104
Heat shock protein 104

1

3

High-throughput

0.407

High

742492

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.407

High

752783

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

763501

MDJ1
DnaJ homolog 1, mitochondrial

1

7

High-throughput

0.407

High

798075

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

15

High-throughput

0.407

High

811412

CAJ1
Protein CAJ1

1

7

High-throughput

0.407

High

814954

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

1

High-throughput

0.407

High

816426

HSP7E
Heat shock protein SSC3, mitochondrial

1

15

High-throughput

0.407

High

850654

ERJ5
ER-localized J domain-containing protein 5

1

8

High-throughput

0.407

High

871452

HLJ1
Protein HLJ1

1

3

High-throughput

0.407

High

1056425

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

9

High-throughput

0.407

High

448411

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.279

Low

568938

INO4
Protein INO4

1

0

High-throughput

0.279

Low

804873

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.249

Low

922957

MPP6
M-phase phosphoprotein 6 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025