Protein: PRTB
Cerevisin (EC 3.4.21.48) (Proteinase YSCB) (Vacuolar protease B) (PrB)

Gene: PRTB, PRB1
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: P09232

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0000328 - fungal-type vacuole lumen
GO:0000425 - pexophagy
GO:0004252 - serine-type endopeptidase activity
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

479954

HSP71
Heat shock protein SSA1

5

5

High-throughput

0.635

High

392046

HSP82
ATP-dependent molecular chaperone HSP82

3

5

High-throughput

0.585

High

479957

SYQ
Glutamine--tRNA ligase

2

1

High-throughput

0.549

High

480006

CDC53
Cell division control protein 53

2

2

High-throughput

0.549

High

479971

MKK2
MAP kinase kinase MKK2/SSP33

1

2

High-throughput

0.536

High

479994

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

1

High-throughput

0.515

High

448604

SNF1
Carbon catabolite-derepressing protein kinase

1

1

High-throughput

0.489

High

470083

SPS1
Sporulation-specific protein 1

1

1

High-throughput

0.489

High

479986

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.489

High

479993

COPA
Coatomer subunit alpha

1

2

High-throughput

0.489

High

479995

CBK1
Serine/threonine-protein kinase CBK1

1

1

High-throughput

0.489

High

480008

RIO1
Serine/threonine-protein kinase RIO1

1

0

Small-scale

0.460

High

479953

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.458

High

479960

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.458

High

479978

IMB2
Importin subunit beta-2

1

1

Small-scale

0.457

High

479958

SEC63
Protein translocation protein SEC63

1

2

Small-scale

0.439

High

416844

CDC25
Cell division control protein 25

1

2

High-throughput

0.437

High

479959

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.437

High

479962

PDI
Protein disulfide-isomerase

1

3

High-throughput

0.437

High

479967

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

479970

EUG1
Protein disulfide-isomerase EUG1

1

3

High-throughput

0.437

High

479973

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

2

High-throughput

0.437

High

479977

AKL1
Serine/threonine-protein kinase AKL1

1

2

High-throughput

0.437

High

479983

RSP5
E3 ubiquitin-protein ligase RSP5

1

2

High-throughput

0.437

High

479987

RIM15
Serine/threonine-protein kinase RIM15

1

3

High-throughput

0.437

High

479998

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

480000

SEC13
Protein transport protein SEC13

1

1

High-throughput

0.437

High

480009

SIZ2
E3 SUMO-protein ligase SIZ2

1

1

High-throughput

0.437

High

479955

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.407

High

479956

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.407

High

479964

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.407

High

479984

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.407

High

479999

GCN5
Histone acetyltransferase GCN5

1

1

High-throughput

0.407

High

479980

SAF1
SCF-associated factor 1

3

0

Small-scale

0.342

High

479990

SKP1
Suppressor of kinetochore protein 1

2

0

High-throughput

0.313

High

479981

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

2

0

High-throughput

0.298

High

479961

HPR1
THO complex subunit HPR1

1

0

High-throughput

0.279

Low

479963

YPK2
Serine/threonine-protein kinase YPK2/YKR2

1

0

High-throughput

0.279

Low

479969

NTH1
Endonuclease III homolog 1

1

0

High-throughput

0.279

Low

479979

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

479985

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.279

Low

480010

RAD59
DNA repair protein RAD59

1

0

High-throughput

0.279

Low

480011

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.279

Low

479989

INP52
Polyphosphatidylinositol phosphatase INP52

1

0

High-throughput

0.269

Low

479965

PBN1
Protein PBN1

1

0

Small-scale

0.265

Low

479988

LSM1
LSM1-LSM7 complex subunit LSM1

1

0

High-throughput

0.265

Low

479997

H3
Histone H3

1

0

Small-scale

0.261

Low

401825

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.249

Low

479966

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

0

High-throughput

0.249

Low

479968

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

479974

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

479975

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.249

Low

479976

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.249

Low

479982

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.249

Low

479991

YG34
Uncharacterized protein YGR122W

1

0

High-throughput

0.249

Low

479992

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.249

Low

479996

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

480001

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

480002

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low

480004

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

480005

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.249

Low

480007

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

480012

NAA25
N-terminal acetyltransferase B complex subunit MDM20

1

0

High-throughput

0.249

Low

480013

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.249

Low

479972

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.238

Low

480003

RBX1
RING-box protein HRT1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025