Protein: IWS1
Transcription factor SPN1 (Interacts with SPT6 protein 1) (Suppresses postrecruitment functions protein 1)

Gene: IWS1, SPN1
Organism: Saccharomyces cerevisiae S288C
Interactions: 68
UniProt ID: Q06505

Gene Ontology (top 5):
GO:0000993 - RNA polymerase II complex binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005665 - RNA polymerase II, core complex
GO:0006334 - nucleosome assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

661197

SPT6
Transcription elongation factor SPT6

15

3

Small-scale

0.761

High

402121

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

1

Small-scale

0.736

High

594584

RPB3
DNA-directed RNA polymerase II subunit RPB3

7

0

Small-scale

0.707

High

470597

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

1

High-throughput

0.688

High

694651

SPT5
Transcription elongation factor SPT5

4

1

Small-scale

0.672

High

382366

H4
Histone H4

3

1

Small-scale

0.651

High

963739

H3
Histone H3

2

2

Small-scale

0.602

High

780389

ELF1
Transcription elongation factor 1

2

0

Small-scale

0.576

High

806953

RPB11
DNA-directed RNA polymerase II subunit RPB11

2

0

High-throughput

0.576

High

739786

SPT16
FACT complex subunit SPT16

2

0

Small-scale

0.559

High

748308

SPT4
Transcription elongation factor SPT4

2

0

High-throughput

0.559

High

441396

KAPB
cAMP-dependent protein kinase type 2

1

2

High-throughput

0.536

High

632215

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.518

High

449013

TOP2
DNA topoisomerase 2

1

1

High-throughput

0.479

High

643666

SNF2
Transcription regulatory protein SNF2

1

1

Small-scale

0.479

High

647231

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

708270

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

708789

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

863956

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

3

High-throughput

0.479

High

826089

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.460

High

435379

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

632114

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.458

High

632292

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

632374

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

671158

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

680086

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

699973

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.458

High

735179

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

736736

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

757348

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

795232

NU170
Nucleoporin NUP170

1

0

High-throughput

0.458

High

808917

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

826861

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

836556

T2FB
Transcription initiation factor IIF subunit beta

1

0

High-throughput

0.458

High

849898

IES1
Ino eighty subunit 1

1

0

Small-scale

0.458

High

1025183

SEN1
Helicase SEN1

1

0

High-throughput

0.458

High

1029637

MCE1
mRNA-capping enzyme subunit alpha

1

0

High-throughput

0.458

High

1031056

NOP3
Serine/arginine

1

0

Small-scale

0.458

High

1055424

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

1055427

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

1055428

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1055429

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

1055430

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

381278

H2B1
Histone H2B.1

1

4

High-throughput

0.445

High

546399

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

1035337

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

2

High-throughput

0.445

High

792968

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.438

High

504430

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

1046937

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

1055425

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

383907

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

410351

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

442124

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

455277

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503255

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

512666

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

513235

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514849

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

558873

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

674850

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

689678

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

753599

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

778547

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

802401

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

874542

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

1033581

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

1055426

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

1035115

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025