Protein: SPT4
Transcription elongation factor SPT4 (Chromatin elongation factor SPT4)

Gene: SPT4
Organism: Saccharomyces cerevisiae S288C
Interactions: 70
UniProt ID: P32914

Gene Ontology (top 5):
GO:0000182 - rDNA binding
GO:0000776 - kinetochore
GO:0000993 - RNA polymerase II complex binding
GO:0005634 - nucleus
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

694511

SPT5
Transcription elongation factor SPT5

14

4

Small-scale

0.985

High

401946

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

0

Small-scale

0.710

High

594281

RPB3
DNA-directed RNA polymerase II subunit RPB3

7

0

Small-scale

0.707

High

470497

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

1

Small-scale

0.691

High

748280

RPB7
DNA-directed RNA polymerase II subunit RPB7

4

0

High-throughput

0.661

High

632072

RPB4
DNA-directed RNA polymerase II subunit RPB4

4

0

Small-scale

0.653

High

632151

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

4

0

Small-scale

0.649

High

748294

PP4R3
Serine/threonine-protein phosphatase 4 regulatory subunit 3

2

0

Small-scale

0.623

High

632246

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

0

High-throughput

0.622

High

699942

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

0

High-throughput

0.622

High

748286

RPB11
DNA-directed RNA polymerase II subunit RPB11

3

0

Small-scale

0.613

High

449285

RAD10
DNA repair protein RAD10

3

0

Small-scale

0.612

High

734846

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

2

1

Small-scale

0.611

High

748284

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

2

0

Small-scale

0.602

High

748295

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

1

High-throughput

0.584

High

748306

POB3
FACT complex subunit POB3

2

1

High-throughput

0.584

High

737811

HOG1
Mitogen-activated protein kinase HOG1

2

0

Small-scale

0.569

High

632330

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

0

High-throughput

0.559

High

645041

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

0

High-throughput

0.559

High

661155

SPT6
Transcription elongation factor SPT6

2

0

High-throughput

0.559

High

739577

SPT16
FACT complex subunit SPT16

2

0

High-throughput

0.559

High

748292

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

2

0

High-throughput

0.559

High

748296

T2FA
Transcription initiation factor IIF subunit alpha

2

0

High-throughput

0.559

High

748299

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

2

0

High-throughput

0.559

High

748308

IWS1
Transcription factor SPN1

2

0

High-throughput

0.559

High

644898

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

1

Small-scale

0.536

High

721802

XPO1
Exportin-1

1

1

High-throughput

0.536

High

748291

RSP5
E3 ubiquitin-protein ligase RSP5

1

2

High-throughput

0.501

High

585894

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.493

High

737625

HIR1
Protein HIR1

1

0

Small-scale

0.493

High

748285

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.480

High

381042

H2B1
Histone H2B.1

1

3

High-throughput

0.479

High

381470

H2B2
Histone H2B.2

1

3

High-throughput

0.479

High

748304

MCE1
mRNA-capping enzyme subunit alpha

1

1

High-throughput

0.479

High

748305

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

748311

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.460

High

148868

CET1
mRNA-capping enzyme subunit beta

1

0

High-throughput

0.458

High

381989

H4
Histone H4

1

0

High-throughput

0.458

High

419671

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

448946

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.458

High

561452

TBP
TATA-box-binding protein

1

0

High-throughput

0.458

High

706628

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

744696

MCES
mRNA cap guanine-N(7) methyltransferase

1

0

High-throughput

0.458

High

748281

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

748283

ELF1
Transcription elongation factor 1

1

0

High-throughput

0.458

High

748287

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

748297

T2FB
Transcription initiation factor IIF subunit beta

1

0

High-throughput

0.458

High

748302

RTF1
RNA polymerase-associated protein RTF1

1

0

High-throughput

0.458

High

748303

SEN1
Helicase SEN1

1

0

High-throughput

0.458

High

748309

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

748310

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

523471

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

526274

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

544298

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

741255

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

748293

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

743965

RAD23
UV excision repair protein RAD23

1

1

High-throughput

0.437

High

748289

CAJ1
Protein CAJ1

1

0

High-throughput

0.426

High

748300

DPH4
Diphthamide biosynthesis protein 4

1

0

High-throughput

0.426

High

748282

LHS1
Heat shock protein 70 homolog LHS1

1

2

High-throughput

0.407

High

748307

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

2

High-throughput

0.407

High

748298

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.269

Low

627756

TYR1
Prephenate dehydrogenase [NADP(+)]

1

0

Small-scale

0.249

Low

672637

BPH1
Beige protein homolog 1

1

0

High-throughput

0.249

Low

748290

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

579105

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.232

Low

626673

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

748279

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

748288

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low

748301

HLJ1
Protein HLJ1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025