Protein: TLCD4
TLC domain-containing protein 4 (Transmembrane protein 56)

Gene: TLCD4
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q96MV1

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0016020 - membrane
GO:0055088 - lipid homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1388162

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

3

0

High-throughput

0.636

High

1291759

S22AG
Solute carrier family 22 member 16

2

2

High-throughput

0.628

High

1398494

GPR52
G-protein coupled receptor 52

3

1

High-throughput

0.609

High

239474

AGRB3
Adhesion G protein-coupled receptor B3

2

1

High-throughput

0.606

High

932704

EMP1
Epithelial membrane protein 1

2

1

High-throughput

0.606

High

1384623

S67A1
Solute carrier family 67 member A1

2

1

High-throughput

0.606

High

1398468

EMC6
ER membrane protein complex subunit 6

2

1

High-throughput

0.606

High

1398484

AT131
Endoplasmic reticulum transmembrane helix translocase

2

1

High-throughput

0.606

High

1398490

AGRE2
Adhesion G protein-coupled receptor E2

2

1

High-throughput

0.606

High

225384

ERD23
ER lumen protein-retaining receptor 3

2

0

High-throughput

0.602

High

144472

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

160324

GOSR2
Golgi SNAP receptor complex member 2

2

0

High-throughput

0.580

High

162259

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.580

High

257662

PRAF2
PRA1 family protein 2

2

0

High-throughput

0.580

High

388279

GLPA
Glycophorin-A

2

0

High-throughput

0.580

High

407513

K2C1
Keratin, type II cytoskeletal 1

2

0

High-throughput

0.580

High

483952

HMOX1
Heme oxygenase 1

2

0

High-throughput

0.580

High

642273

COMT
Catechol O-methyltransferase

2

0

High-throughput

0.580

High

789948

FDFT
Squalene synthase

2

0

High-throughput

0.580

High

907830

CLCN7
H(+)/Cl(-) exchange transporter 7

2

0

High-throughput

0.580

High

1092082

BNIP3
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

2

0

High-throughput

0.580

High

1142922

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

1195543

CTXN3
Cortexin-3

2

0

High-throughput

0.580

High

1272374

FA2H
Fatty acid 2-hydroxylase

2

0

High-throughput

0.580

High

1280163

PRRT2
Proline-rich transmembrane protein 2

2

0

High-throughput

0.580

High

1333265

T229B
Transmembrane protein 229B

2

0

High-throughput

0.580

High

1346723

SCAM5
Secretory carrier-associated membrane protein 5

2

0

High-throughput

0.580

High

1356596

CHPT1
Cholinephosphotransferase 1

2

0

High-throughput

0.580

High

1393235

TMM19
Transmembrane protein 19

2

0

High-throughput

0.580

High

1393434

REEP6
Receptor expression-enhancing protein 6

2

0

High-throughput

0.580

High

1398465

TM237
Transmembrane protein 237

2

0

High-throughput

0.580

High

1398467

YIPF4
Protein YIPF4

2

0

High-throughput

0.580

High

1398470

CLC7A
C-type lectin domain family 7 member A

2

0

High-throughput

0.580

High

1398476

TMM60
Transmembrane protein 60

2

0

High-throughput

0.580

High

1398487

CC167
Coiled-coil domain-containing protein 167

2

0

High-throughput

0.580

High

1398488

ORML1
ORM1-like protein 1

2

0

High-throughput

0.580

High

1398489

NAT8
N-acetyltransferase 8

2

0

High-throughput

0.580

High

1398491

LCAP
Leucyl-cystinyl aminopeptidase

2

0

High-throughput

0.580

High

1398492

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.580

High

1398498

SERP1
Stress-associated endoplasmic reticulum protein 1

2

0

High-throughput

0.580

High

1159098

C3AR
C3a anaphylatoxin chemotactic receptor

2

2

High-throughput

0.574

High

1308940

S22A9
Organic anion transporter 7

2

2

High-throughput

0.574

High

1398466

GPR21
Probable G-protein coupled receptor 21

2

1

High-throughput

0.574

High

280306

SC22B
Vesicle-trafficking protein SEC22b

2

1

High-throughput

0.553

High

1005407

CP4F2
Cytochrome P450 4F2

2

1

High-throughput

0.553

High

1030379

PMP22
Peripheral myelin protein 22

2

1

High-throughput

0.553

High

1238077

CP4FN
Ultra-long-chain fatty acid omega-hydroxylase

2

1

High-throughput

0.553

High

1394435

SC22A
Vesicle-trafficking protein SEC22a

2

1

High-throughput

0.553

High

1398469

SFXN3
Sideroflexin-3

2

1

High-throughput

0.553

High

1398480

SYNG1
Synapse differentiation-inducing gene protein 1

2

1

High-throughput

0.553

High

1398481

SFXN1
Sideroflexin-1

2

1

High-throughput

0.553

High

1398495

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

2

High-throughput

0.553

High

1398497

YIPF1
Protein YIPF1

2

1

High-throughput

0.553

High

132643

UPK1A
Uroplakin-1a

1

1

High-throughput

0.536

High

182735

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.536

High

1393064

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.536

High

1398479

AT133
Polyamine-transporting ATPase 13A3

1

1

High-throughput

0.536

High

564230

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

1053052

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.513

High

1053828

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.513

High

1239033

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.513

High

1398477

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

560055

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.493

High

832443

OPRX
Nociceptin receptor

1

1

High-throughput

0.489

High

956983

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.489

High

1398472

S22A4
Solute carrier family 22 member 4

1

2

High-throughput

0.489

High

1338039

TMIE
Transmembrane inner ear expressed protein

1

0

High-throughput

0.460

High

1398474

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.460

High

1398496

LOXL2
Lysyl oxidase homolog 2

1

0

Small-scale

0.426

High

1398478

SG196
Protein O-mannose kinase

3

0

High-throughput

0.347

High

596769

DPEP1
Dipeptidase 1

2

0

High-throughput

0.328

High

1340737

TPC2
Two pore channel protein 2

2

0

High-throughput

0.328

High

1398471

YIPF3
Protein YIPF3

2

0

High-throughput

0.328

High

49687

T120B
Transmembrane protein 120B

2

0

High-throughput

0.316

High

168115

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

2

0

High-throughput

0.316

High

328259

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

2

0

High-throughput

0.316

High

391749

STAT
Statherin

2

0

High-throughput

0.316

High

666016

IBP5
Insulin-like growth factor-binding protein 5

2

0

High-throughput

0.316

High

706046

CXB2
Gap junction beta-2 protein

2

0

High-throughput

0.316

High

944417

SYJ2B
Synaptojanin-2-binding protein

2

0

High-throughput

0.316

High

1055139

CCG1
Voltage-dependent calcium channel gamma-1 subunit

2

0

High-throughput

0.316

High

1081328

SMAGP
Small cell adhesion glycoprotein

2

0

High-throughput

0.316

High

1089155

TM115
Transmembrane protein 115

2

0

High-throughput

0.316

High

1159485

NKG7
Protein NKG7

2

0

High-throughput

0.316

High

1205532

M4A13
Membrane-spanning 4-domains subfamily A member 13

2

0

High-throughput

0.316

High

1294815

STX12
Syntaxin-12

2

0

High-throughput

0.316

High

1308782

S41A1
Solute carrier family 41 member 1

2

0

High-throughput

0.316

High

1327862

DHRSX
Polyprenol dehydrogenase

2

0

High-throughput

0.316

High

1371126

NINJ1
Ninjurin-1

2

0

High-throughput

0.316

High

1398473

FXYD6
FXYD domain-containing ion transport regulator 6

2

0

High-throughput

0.316

High

1398475

ARV1
Protein ARV1

2

0

High-throughput

0.316

High

1398486

TV23B
Golgi apparatus membrane protein TVP23 homolog B

2

0

High-throughput

0.316

High

349537

TSN15
Tetraspanin-15

1

0

High-throughput

0.279

Low

1348621

S7A14
Solute carrier family 7 member 14

1

0

High-throughput

0.279

Low

1398485

SC5A4
Probable glucose sensor protein SLC5A4

1

0

High-throughput

0.279

Low

1398493

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

1398482

MYG1
MYG1 exonuclease

1

0

High-throughput

0.268

Low

1398483

VEZA
Vezatin

1

0

High-throughput

0.251

Low

294195

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025