Protein: ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2 (ITI heavy chain H2) (ITI-HC2) (Inter-alpha-inhibitor heavy chain 2) (Inter-alpha-trypsin inhibitor complex component II) (Serum-derived hyaluronan-associated protein) (SHAP)

Gene: ITIH2
Organism: Homo sapiens
Interactions: 88
UniProt ID: P19823

Gene Ontology (top 5):
GO:0004866 - endopeptidase inhibitor activity
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005540 - hyaluronic acid binding
GO:0005576 - extracellular region
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587348

CEA21
Carcinoembryonic antigen-related cell adhesion molecule 21

3

4

High-throughput

0.770

High

126351

MATN2
Matrilin-2

1

8

High-throughput

0.691

High

198396

KLK10
Kallikrein-10

1

4

High-throughput

0.691

High

246319

KERA
Keratocan

1

5

High-throughput

0.691

High

429266

PGS2
Decorin

1

5

High-throughput

0.691

High

439060

ELNE
Neutrophil elastase

1

5

High-throughput

0.691

High

587331

CMA1
Chymase

1

3

High-throughput

0.691

High

587334

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

4

High-throughput

0.691

High

587369

ASPN
Asporin

1

5

High-throughput

0.691

High

587379

OPT
Opticin

1

6

High-throughput

0.691

High

181658

FGF10
Fibroblast growth factor 10

3

1

High-throughput

0.667

High

496275

TAU
Microtubule-associated protein tau

3

4

Small-scale

0.624

High

587342

TSG6
Tumor necrosis factor-inducible gene 6 protein

2

2

Small-scale

0.619

High

587374

LRC4C
Leucine-rich repeat-containing protein 4C

1

2

High-throughput

0.618

High

587364

PAUF
Pancreatic adenocarcinoma up-regulated factor

2

0

High-throughput

0.602

High

305210

NXPH2
Neurexophilin-2

2

0

High-throughput

0.585

High

352485

TNFA
Tumor necrosis factor

2

0

High-throughput

0.585

High

59732

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

0

High-throughput

0.578

High

587349

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.575

High

337918

EGFR
Epidermal growth factor receptor

2

5

High-throughput

0.543

High

131873

UPK2
Uroplakin-2

1

1

High-throughput

0.536

High

238478

CST8
Cystatin-8

1

2

High-throughput

0.536

High

265755

CRLF1
Cytokine receptor-like factor 1

1

1

High-throughput

0.536

High

389440

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

5

High-throughput

0.536

High

441806

FGF4
Fibroblast growth factor 4

1

1

High-throughput

0.536

High

448902

MMP10
Stromelysin-2

1

4

High-throughput

0.536

High

587332

PTX3
Pentraxin-related protein PTX3

1

1

High-throughput

0.536

High

587343

DDR1
Epithelial discoidin domain-containing receptor 1

1

4

High-throughput

0.536

High

587347

PGFRL
Platelet-derived growth factor receptor-like protein

1

1

High-throughput

0.536

High

587368

ERP44
Endoplasmic reticulum resident protein 44

1

3

High-throughput

0.536

High

587370

ANGL4
Angiopoietin-related protein 4

1

4

High-throughput

0.536

High

587372

CSTL1
Cystatin-like 1

1

2

High-throughput

0.536

High

587377

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

1

High-throughput

0.536

High

587386

LIPG
Endothelial lipase

1

2

High-throughput

0.536

High

236356

B4GT4
Beta-1,4-galactosyltransferase 4

1

0

High-throughput

0.513

High

578222

LAG3
Lymphocyte activation gene 3 protein

1

0

High-throughput

0.513

High

587330

MCH
Pro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid

1

0

High-throughput

0.513

High

587345

NOGG
Noggin

1

0

High-throughput

0.513

High

587361

KRT35
Keratin, type I cuticular Ha5

1

0

High-throughput

0.513

High

587371

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

587373

RISC
Retinoid-inducible serine carboxypeptidase

1

0

High-throughput

0.513

High

587378

GALP
Galanin-like peptide

1

0

High-throughput

0.513

High

587381

TKNK
Tachykinin-3

1

0

High-throughput

0.513

High

199866

SPIT2
Kunitz-type protease inhibitor 2

1

3

Small-scale

0.501

High

134322

MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe

1

1

High-throughput

0.489

High

183018

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

328105

SG1D1
Secretoglobin family 1D member 1

1

6

High-throughput

0.489

High

528522

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.489

High

587335

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.489

High

587336

RYK
Tyrosine-protein kinase RYK

1

5

High-throughput

0.489

High

587338

DPP6
Dipeptidyl aminopeptidase-like protein 6

1

1

High-throughput

0.489

High

587339

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

1

High-throughput

0.489

High

587350

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

2

High-throughput

0.489

High

587353

PDILT
Protein disulfide-isomerase-like protein of the testis

1

3

High-throughput

0.489

High

587356

B3GN7
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

1

1

High-throughput

0.489

High

587357

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.489

High

587358

LIPH
Lipase member H

1

2

High-throughput

0.489

High

587362

SPSB4
SPRY domain-containing SOCS box protein 4

1

9

High-throughput

0.489

High

587366

SPSB2
SPRY domain-containing SOCS box protein 2

1

8

High-throughput

0.489

High

587367

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.489

High

587382

PHF11
PHD finger protein 11

1

2

High-throughput

0.489

High

587383

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

2

High-throughput

0.489

High

587351

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.480

High

362803

FINC
Fibronectin

1

9

Small-scale

0.479

High

587341

H31
Histone H3.1

1

1

High-throughput

0.479

High

226493

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.437

High

260471

PITX3
Pituitary homeobox 3

1

2

Small-scale

0.437

High

373663

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.437

High

587360

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

587380

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

587354

GDPD1
Lysophospholipase D GDPD1

3

0

High-throughput

0.347

High

519321

FCGR1
High affinity immunoglobulin gamma Fc receptor I

2

0

High-throughput

0.328

High

587384

DKKL1
Dickkopf-like protein 1

2

0

High-throughput

0.328

High

587337

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.282

High

159756

LECT2
Leukocyte cell-derived chemotaxin-2

1

0

High-throughput

0.279

Low

587333

NEC1
Neuroendocrine convertase 1

1

0

High-throughput

0.279

Low

587359

DCNL4
DCN1-like protein 4

1

0

High-throughput

0.279

Low

587363

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

587365

O52B2
Olfactory receptor 52B2

1

0

High-throughput

0.279

Low

587385

CD11A
Cyclin-dependent kinase 11A

1

0

High-throughput

0.279

Low

587387

HS3S4
Heparan sulfate glucosamine 3-O-sulfotransferase 4

1

0

High-throughput

0.279

Low

587340

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

587344

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.249

Low

587346

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

587352

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.249

Low

587355

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

0

Small-scale

0.249

Low

587375

ANLN
Anillin

1

0

High-throughput

0.249

Low

587376

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024