Protein: OBI1
ORC ubiquitin ligase 1 (OBI1) (EC 2.3.2.27) (RING finger protein 219)

Gene: OBI1
Organism: Homo sapiens
Interactions: 175
UniProt ID: Q5W0B1

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0006275 - regulation of DNA replication
GO:0006513 - protein monoubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1219831

OBI1
ORC ubiquitin ligase 1

2

0

Small-scale

0.738

High

906675

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

1

Small-scale

0.647

High

982208

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

1

Small-scale

0.647

High

970647

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.618

High

1219899

CNOT2
CCR4-NOT transcription complex subunit 2

3

1

Small-scale

0.606

High

273879

CNOT3
CCR4-NOT transcription complex subunit 3

3

2

Small-scale

0.603

High

1113360

CUL3
Cullin-3

2

0

High-throughput

0.585

High

1215659

RC3H1
Roquin-1

2

1

Small-scale

0.584

High

260075

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.576

High

230909

ORC5
Origin recognition complex subunit 5

1

1

Small-scale

0.561

High

1219877

CNO6L
CCR4-NOT transcription complex subunit 6-like

2

1

High-throughput

0.558

High

1219906

CNOT7
CCR4-NOT transcription complex subunit 7

2

1

Small-scale

0.543

High

1219901

ORC3
Origin recognition complex subunit 3

1

0

Small-scale

0.537

High

1219880

CEP89
Centrosomal protein of 89 kDa

2

1

High-throughput

0.533

High

1219887

TB182
182 kDa tankyrase-1-binding protein

2

1

High-throughput

0.533

High

256893

H2B1K
Histone H2B type 1-K

1

0

High-throughput

0.517

High

937638

FOXG1
Forkhead box protein G1

1

0

High-throughput

0.513

High

949498

NANO2
Nanos homolog 2

1

0

High-throughput

0.513

High

1207217

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

1

0

High-throughput

0.513

High

1219833

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.513

High

1219849

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1219884

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

1219886

TX13A
Testis-expressed protein 13A

1

0

High-throughput

0.513

High

274622

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.489

High

761708

HSP74
Heat shock 70 kDa protein 4

1

1

High-throughput

0.489

High

1219844

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

1

High-throughput

0.489

High

1219855

DNJB8
DnaJ homolog subfamily B member 8

1

1

High-throughput

0.489

High

1219870

HDA11
Histone deacetylase 11

1

1

High-throughput

0.489

High

1219883

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.489

High

1219896

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

1

High-throughput

0.489

High

1006469

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.480

High

920032

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

1201939

BRDT
Bromodomain testis-specific protein

1

1

High-throughput

0.479

High

1219872

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

1

Small-scale

0.479

High

1219876

IFT74
Intraflagellar transport protein 74 homolog

1

1

High-throughput

0.479

High

1219894

RC3H2
Roquin-2

1

2

High-throughput

0.479

High

67773

TBKB1
TANK-binding kinase 1-binding protein 1

1

0

High-throughput

0.458

High

246670

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

274160

ANR17
Ankyrin repeat domain-containing protein 17

1

0

High-throughput

0.458

High

350040

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

414009

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

588903

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

695685

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

791454

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

869045

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

1104316

ORC1
Origin recognition complex subunit 1

1

0

Small-scale

0.458

High

1109810

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1198981

KLH12
Kelch-like protein 12

1

0

Small-scale

0.458

High

1219835

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1219839

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1219854

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1219864

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1219869

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

1219873

RNF31
E3 ubiquitin-protein ligase RNF31

1

0

High-throughput

0.458

High

1219888

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

Small-scale

0.458

High

1219893

BRF2
Transcription factor IIIB 50 kDa subunit

1

0

High-throughput

0.458

High

1219897

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

1219898

TRM1
tRNA

1

0

High-throughput

0.458

High

1219903

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

Small-scale

0.458

High

1219907

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

1219910

CNOT6
CCR4-NOT transcription complex subunit 6

1

1

Small-scale

0.457

High

862659

UTRN
Utrophin

1

1

High-throughput

0.457

High

133754

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.438

High

1219846

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

0

High-throughput

0.438

High

1219858

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

0

High-throughput

0.438

High

170194

AURKA
Aurora kinase A

1

1

High-throughput

0.437

High

346646

TTC4
Tetratricopeptide repeat protein 4

1

2

High-throughput

0.437

High

1105619

GOGA4
Golgin subfamily A member 4

1

2

High-throughput

0.437

High

1117386

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

High-throughput

0.437

High

1124470

MAP7
Ensconsin

1

1

High-throughput

0.437

High

1219837

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

1219850

MACOI
Macoilin

1

1

High-throughput

0.437

High

1219853

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

1

High-throughput

0.437

High

1219863

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.437

High

1219874

AURKB
Aurora kinase B

1

1

High-throughput

0.437

High

1219904

CNOT8
CCR4-NOT transcription complex subunit 8

1

1

High-throughput

0.437

High

1219911

CP131
Centrosomal protein of 131 kDa

1

2

High-throughput

0.437

High

1219912

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

1

High-throughput

0.437

High

1219913

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

1

High-throughput

0.437

High

503604

TFPT
TCF3 fusion partner

1

0

High-throughput

0.426

High

1103226

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

1219862

DDB2
DNA damage-binding protein 2

1

0

High-throughput

0.426

High

1219900

WRP73
WD repeat-containing protein WRAP73

6

0

High-throughput

0.380

High

64036

CNOT1
CCR4-NOT transcription complex subunit 1

4

0

Small-scale

0.364

High

1219892

CNO10
CCR4-NOT transcription complex subunit 10

4

0

Small-scale

0.359

High

1219909

CNO11
CCR4-NOT transcription complex subunit 11

4

0

Small-scale

0.358

High

1219851

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

3

0

High-throughput

0.349

High

897463

TOB1
Protein Tob1

2

0

High-throughput

0.328

High

1219865

CNOT9
CCR4-NOT transcription complex subunit 9

2

0

Small-scale

0.325

High

764367

CTNA1
Catenin alpha-1

2

0

Small-scale

0.320

High

1219848

RIBC1
RIB43A-like with coiled-coils protein 1

2

0

High-throughput

0.313

High

1219879

FACOS
FANCD2 opposite strand protein

2

0

High-throughput

0.313

High

1219908

AGO2
Protein argonaute-2

2

0

High-throughput

0.305

High

1219867

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.298

High

48150

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.279

Low

289780

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

336972

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

High-throughput

0.279

Low

347097

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

947469

RAB15
Ras-related protein Rab-15

1

0

High-throughput

0.279

Low

954703

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.279

Low

1064570

HDHD1
Pseudouridine-5'-phosphatase

1

0

High-throughput

0.279

Low

1163918

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.279

Low

1211419

CF141
Uncharacterized protein C6orf141

1

0

High-throughput

0.279

Low

1219834

BORA
Protein aurora borealis

1

0

High-throughput

0.279

Low

1219842

FA83A
Protein FAM83A

1

0

High-throughput

0.279

Low

1219843

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1219845

AN13A
Ankyrin repeat domain-containing protein 13A

1

0

High-throughput

0.279

Low

1219856

UHMK1
Serine/threonine-protein kinase Kist

1

0

High-throughput

0.279

Low

1219875

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.279

Low

1219878

F218A
Protein FAM218A

1

0

High-throughput

0.279

Low

1219889

RPP21
Ribonuclease P protein subunit p21

1

0

High-throughput

0.279

Low

1219890

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.279

Low

1219891

SYNCI
Syncoilin

1

0

High-throughput

0.279

Low

1219902

NLK
Serine/threonine-protein kinase NLK

1

0

High-throughput

0.279

Low

1219914

COR2B
Coronin-2B

1

0

High-throughput

0.279

Low

1219840

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.268

Low

1209240

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.261

Low

1219881

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.251

Low

166668

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

0

High-throughput

0.249

Low

172927

XPO1
Exportin-1

1

0

High-throughput

0.249

Low

176490

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

253768

UGDH
UDP-glucose 6-dehydrogenase

1

0

Small-scale

0.249

Low

293832

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

319832

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

385839

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.249

Low

451002

LDHB
L-lactate dehydrogenase B chain

1

0

High-throughput

0.249

Low

618700

ML12A
Myosin regulatory light chain 12A

1

0

Small-scale

0.249

Low

664765

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.249

Low

683255

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.249

Low

730664

1433S
14-3-3 protein sigma

1

0

High-throughput

0.249

Low

768405

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

862868

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.249

Low

867201

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.249

Low

897578

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.249

Low

959822

RS3A
Small ribosomal subunit protein eS1

1

0

Small-scale

0.249

Low

975743

RL7A
Large ribosomal subunit protein eL8

1

0

Small-scale

0.249

Low

1004270

F193A
Protein FAM193A

1

0

High-throughput

0.249

Low

1026076

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.249

Low

1041115

CAV1
Caveolin-1

1

0

Small-scale

0.249

Low

1104349

ORC2
Origin recognition complex subunit 2

1

0

Small-scale

0.249

Low

1105962

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.249

Low

1135709

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1140407

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1143154

PLEC
Plectin

1

0

Small-scale

0.249

Low

1161489

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.249

Low

1193531

CRY2
Cryptochrome-2

1

0

High-throughput

0.249

Low

1196986

AMOT
Angiomotin

1

0

High-throughput

0.249

Low

1219838

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1219841

N4BP2
NEDD4-binding protein 2

1

0

High-throughput

0.249

Low

1219847

STK40
Serine/threonine-protein kinase 40

1

0

Small-scale

0.249

Low

1219857

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low

1219860

IFT81
Intraflagellar transport protein 81 homolog

1

0

High-throughput

0.249

Low

1219866

MY18A
Unconventional myosin-XVIIIa

1

0

Small-scale

0.249

Low

1219882

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.249

Low

1219885

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.249

Low

1219895

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low

1219905

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.249

Low

322734

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.238

Low

472811

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.238

Low

963429

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.238

Low

1133338

PTGR1
Prostaglandin reductase 1

1

0

High-throughput

0.238

Low

1219868

FUBP1
Far upstream element-binding protein 1

1

0

High-throughput

0.238

Low

87488

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low

244980

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low

294727

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.232

Low

537324

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.232

Low

946141

MLF1
Myeloid leukemia factor 1

1

0

High-throughput

0.232

Low

1178834

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.232

Low

1219832

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.232

Low

1219836

CCNI2
Cyclin-I2

1

0

High-throughput

0.232

Low

1219852

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1219859

NET5
Netrin-5

1

0

High-throughput

0.232

Low

1219861

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.232

Low

1219871

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025