Protein: NEK6
Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512)

Gene: NEK6
Organism: Homo sapiens
Interactions: 181
UniProt ID: Q9HC98

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000922 - spindle pole
GO:0001222 - transcription corepressor binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1254381

NEK9
Serine/threonine-protein kinase Nek9

8

19

Small-scale

0.974

High

1255598

NEK7
Serine/threonine-protein kinase Nek7

6

16

High-throughput

0.950

High

1335910

IKZF3
Zinc finger protein Aiolos

5

11

High-throughput

0.925

High

1191794

NECA2
N-terminal EF-hand calcium-binding protein 2

5

0

High-throughput

0.879

High

473719

ZN688
Zinc finger protein 688

2

5

High-throughput

0.783

High

563678

ZNF24
Zinc finger protein 24

2

8

High-throughput

0.783

High

1153391

PKHA7
Pleckstrin homology domain-containing family A member 7

2

20

High-throughput

0.783

High

1157044

ZN774
Zinc finger protein 774

2

6

High-throughput

0.783

High

1158442

ZN343
Zinc finger protein 343

2

9

High-throughput

0.783

High

1243031

GLIS3
Zinc finger protein GLIS3

2

14

High-throughput

0.783

High

1257167

ZFP90
Zinc finger protein 90 homolog

2

8

High-throughput

0.783

High

1294333

PP16A
Protein phosphatase 1 regulatory subunit 16A

2

2

High-throughput

0.783

High

1302376

ZN587
Zinc finger protein 587

2

5

High-throughput

0.783

High

1335898

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

9

High-throughput

0.783

High

1335902

RBAK
RB-associated KRAB zinc finger protein

2

3

High-throughput

0.783

High

992606

ACK1
Activated CDC42 kinase 1

1

20

High-throughput

0.740

High

1033742

IKZF1
DNA-binding protein Ikaros

1

6

High-throughput

0.740

High

551282

ITF2
Transcription factor 4

4

3

High-throughput

0.705

High

1335897

PAK6
Serine/threonine-protein kinase PAK 6

1

16

High-throughput

0.698

High

1139089

TASO2
Protein TASOR 2

4

8

High-throughput

0.698

High

1147970

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

1

5

High-throughput

0.691

High

1173316

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

1

15

High-throughput

0.691

High

894456

CDC42
Cell division control protein 42 homolog

1

13

Small-scale

0.680

High

1334237

ANRA2
Ankyrin repeat family A protein 2

1

12

Small-scale

0.680

High

1012355

INCA1
Protein INCA1

4

0

High-throughput

0.675

High

537079

TRI27
Zinc finger protein RFP

3

6

High-throughput

0.675

High

1071404

K1H1
Keratin, type I cuticular Ha1

3

7

High-throughput

0.675

High

1149358

K1C40
Keratin, type I cytoskeletal 40

3

5

High-throughput

0.675

High

1308590

DHB14
17-beta-hydroxysteroid dehydrogenase 14

3

1

High-throughput

0.675

High

1310156

LZTS2
Leucine zipper putative tumor suppressor 2

3

20

High-throughput

0.675

High

1082998

CDC37
Hsp90 co-chaperone Cdc37

1

12

High-throughput

0.665

High

850714

KS6A3
Ribosomal protein S6 kinase alpha-3

1

16

High-throughput

0.665

High

1335896

NEK6
Serine/threonine-protein kinase Nek6

1

17

Small-scale

0.647

High

993610

TLE5
TLE family member 5

3

0

High-throughput

0.646

High

1067703

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.630

High

734780

TRI23
E3 ubiquitin-protein ligase TRIM23

2

4

High-throughput

0.628

High

957784

XIAP
E3 ubiquitin-protein ligase XIAP

2

8

High-throughput

0.628

High

928475

DYL1
Dynein light chain 1, cytoplasmic

2

12

High-throughput

0.621

High

1104147

EMAL3
Echinoderm microtubule-associated protein-like 3

2

11

High-throughput

0.621

High

1335034

PRD16
Histone-lysine N-methyltransferase PRDM16

1

6

High-throughput

0.621

High

617020

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

3

Small-scale

0.619

High

172234

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.618

High

673296

WEE1
Wee1-like protein kinase

1

17

High-throughput

0.618

High

1335710

EMAL4
Echinoderm microtubule-associated protein-like 4

2

10

Small-scale

0.611

High

208435

SPY3
Protein sprouty homolog 3

2

2

High-throughput

0.606

High

235597

VINEX
Vinexin

2

17

High-throughput

0.606

High

264408

GGYF1
GRB10-interacting GYF protein 1

2

5

High-throughput

0.606

High

280724

KRT34
Keratin, type I cuticular Ha4

2

5

High-throughput

0.606

High

318891

K2C75
Keratin, type II cytoskeletal 75

2

4

High-throughput

0.606

High

409239

K2C8
Keratin, type II cytoskeletal 8

2

3

High-throughput

0.606

High

422294

NFL
Neurofilament light polypeptide

2

16

High-throughput

0.606

High

535573

GFAP
Glial fibrillary acidic protein

2

16

High-throughput

0.606

High

546109

MYOG
Myogenin

2

3

High-throughput

0.606

High

568045

HXB6
Homeobox protein Hox-B6

2

4

High-throughput

0.606

High

569127

DESM
Desmin

2

16

High-throughput

0.606

High

830029

HXA1
Homeobox protein Hox-A1

2

8

High-throughput

0.606

High

881302

CTBP2
C-terminal-binding protein 2

2

3

High-throughput

0.606

High

889691

KR108
Keratin-associated protein 10-8

2

4

High-throughput

0.606

High

1020941

TRAF2
TNF receptor-associated factor 2

2

13

High-throughput

0.606

High

1087935

PTN21
Tyrosine-protein phosphatase non-receptor type 21

2

15

High-throughput

0.606

High

1110278

KR133
Keratin-associated protein 13-3

2

2

High-throughput

0.606

High

1127590

EFHC2
EF-hand domain-containing family member C2

2

4

High-throughput

0.606

High

1136611

FHL5
Four and a half LIM domains protein 5

2

2

High-throughput

0.606

High

1190659

ZN438
Zinc finger protein 438

2

9

High-throughput

0.606

High

1232772

ZCHC7
Zinc finger CCHC domain-containing protein 7

2

1

High-throughput

0.606

High

1251539

CEP76
Centrosomal protein of 76 kDa

2

1

High-throughput

0.606

High

1256106

SH3R2
E3 ubiquitin-protein ligase SH3RF2

2

13

High-throughput

0.606

High

1263087

MB3L1
Methyl-CpG-binding domain protein 3-like 1

2

1

High-throughput

0.606

High

1287664

DDT4L
DNA damage-inducible transcript 4-like protein

2

3

High-throughput

0.606

High

1289560

HOOK2
Protein Hook homolog 2

2

20

High-throughput

0.606

High

1303320

HTF4
Transcription factor 12

2

3

High-throughput

0.606

High

1310075

TIRR
Tudor-interacting repair regulator protein

2

1

High-throughput

0.606

High

1317454

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.606

High

1327277

KTBL1
KATNB1-like protein 1

2

1

High-throughput

0.606

High

1335899

PICK1
PRKCA-binding protein

2

5

High-throughput

0.606

High

1335905

TFP11
Tuftelin-interacting protein 11

2

2

High-throughput

0.606

High

1335909

ZRAN1
Ubiquitin thioesterase ZRANB1

2

12

High-throughput

0.606

High

1335911

FOXJ3
Forkhead box protein J3

2

9

High-throughput

0.606

High

1335915

LZTS1
Leucine zipper putative tumor suppressor 1

2

20

High-throughput

0.606

High

1335917

GRIP1
Glutamate receptor-interacting protein 1

2

3

High-throughput

0.606

High

1205289

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.586

High

146548

BHE40
Class E basic helix-loop-helix protein 40

2

0

High-throughput

0.580

High

1121671

SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

2

0

High-throughput

0.580

High

1132542

UBX11
UBX domain-containing protein 11

2

0

High-throughput

0.580

High

1190443

F220A
Protein FAM220A

2

0

High-throughput

0.580

High

1298406

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

1309389

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

2

0

High-throughput

0.580

High

1317415

PBX4
Pre-B-cell leukemia transcription factor 4

2

0

High-throughput

0.580

High

1326633

NIF3L
NIF3-like protein 1

2

0

High-throughput

0.580

High

1130613

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

16

High-throughput

0.575

High

527806

LAMP2
Lysosome-associated membrane glycoprotein 2

2

4

High-throughput

0.574

High

1056247

I13R2
Interleukin-13 receptor subunit alpha-2

2

11

High-throughput

0.574

High

1335913

LAMP3
Lysosome-associated membrane glycoprotein 3

2

4

High-throughput

0.574

High

964528

RELB
Transcription factor RelB

1

10

Small-scale

0.573

High

1252490

LNX1
E3 ubiquitin-protein ligase LNX

1

4

High-throughput

0.573

High

655098

PROP
Properdin

2

8

High-throughput

0.553

High

597427

PTN
Pleiotrophin

1

1

Small-scale

0.549

High

1191725

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

6

Small-scale

0.549

High

1300472

PRAM
PML-RARA-regulated adapter molecule 1

1

11

Small-scale

0.549

High

827280

ARRB1
Beta-arrestin-1

1

5

High-throughput

0.541

High

1079300

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.541

High

1335901

KCTD5
BTB/POZ domain-containing protein KCTD5

1

4

High-throughput

0.541

High

1219018

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

147863

RHG33
Rho GTPase-activating protein 33

1

5

Small-scale

0.527

High

671025

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

8

Small-scale

0.527

High

905743

RS7
Small ribosomal subunit protein eS7

1

1

Small-scale

0.527

High

1135059

ER6L2
DNA excision repair protein ERCC-6-like 2

1

3

Small-scale

0.527

High

579292

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.526

High

1076293

TRIP4
Activating signal cointegrator 1

1

0

Small-scale

0.526

High

117831

MYO1C
Unconventional myosin-Ic

1

20

High-throughput

0.515

High

325574

EMAL2
Echinoderm microtubule-associated protein-like 2

1

11

High-throughput

0.515

High

709063

MCM7
DNA replication licensing factor MCM7

1

4

High-throughput

0.515

High

790009

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.515

High

1027799

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

4

High-throughput

0.515

High

1038062

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.515

High

1128438

PCID2
PCI domain-containing protein 2

1

4

High-throughput

0.515

High

1230544

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

High-throughput

0.515

High

1256981

IPO4
Importin-4

1

7

High-throughput

0.515

High

1273740

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

11

High-throughput

0.515

High

1334935

XPO5
Exportin-5

1

18

High-throughput

0.515

High

1335900

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.515

High

1335912

SMC3
Structural maintenance of chromosomes protein 3

1

15

High-throughput

0.515

High

1335914

RUVB2
RuvB-like 2

1

5

High-throughput

0.515

High

653732

CALR
Calreticulin

1

1

High-throughput

0.515

High

1151249

Q6FHY5
MEOX2 protein

1

7

High-throughput

0.515

High

1335908

RIM3A
RIMS-binding protein 3A

1

20

High-throughput

0.515

High

362290

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

198058

PHF1
PHD finger protein 1

1

0

Small-scale

0.504

High

1204207

CIR1
Corepressor interacting with RBPJ 1

1

0

Small-scale

0.504

High

1230824

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.493

High

739296

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

173312

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.489

High

259218

CAD16
Cadherin-16

1

8

High-throughput

0.489

High

985389

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.489

High

1335904

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

63557

RIM3C
RIMS-binding protein 3C

1

20

High-throughput

0.481

High

838290

MEOX2
Homeobox protein MOX-2

1

7

High-throughput

0.481

High

1103197

PRIC4
Prickle-like protein 4

1

6

High-throughput

0.481

High

1215993

KR131
Keratin-associated protein 13-1

1

2

High-throughput

0.481

High

1220213

HOMEZ
Homeobox and leucine zipper protein Homez

1

3

High-throughput

0.481

High

311628

SMC2
Structural maintenance of chromosomes protein 2

1

15

High-throughput

0.479

High

314393

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

3

High-throughput

0.479

High

318022

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

10

High-throughput

0.479

High

437480

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.479

High

660164

RBL1
Retinoblastoma-like protein 1

1

1

High-throughput

0.479

High

803982

NSF
Vesicle-fusing ATPase

1

7

High-throughput

0.479

High

1057397

SMC1A
Structural maintenance of chromosomes protein 1A

1

20

High-throughput

0.479

High

1063372

CND1
Condensin complex subunit 1

1

1

High-throughput

0.479

High

1164711

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

2

High-throughput

0.479

High

1256727

ARH40
Rho guanine nucleotide exchange factor 40

1

5

High-throughput

0.479

High

1268254

GCN1
Stalled ribosome sensor GCN1

1

15

High-throughput

0.479

High

1318490

UCK2
Uridine-cytidine kinase 2

1

2

High-throughput

0.479

High

1327107

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

1335906

MYO1A
Unconventional myosin-Ia

1

17

High-throughput

0.479

High

1335907

COPG2
Coatomer subunit gamma-2

1

4

High-throughput

0.479

High

1335918

TNPO3
Transportin-3

1

16

High-throughput

0.479

High

622711

ERD21
ER lumen protein-retaining receptor 1

1

2

High-throughput

0.470

High

1078166

AAAT
Neutral amino acid transporter B(0)

1

2

High-throughput

0.470

High

1335903

HACD3
Very-long-chain

1

4

High-throughput

0.470

High

522207

CADH1
Cadherin-1

1

6

High-throughput

0.470

High

1238759

GG6L2
Golgin subfamily A member 6-like protein 2

1

20

High-throughput

0.470

High

173777

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.458

High

1204411

CNDG2
Condensin-2 complex subunit G2

1

0

High-throughput

0.458

High

443824

VIME
Vimentin

1

17

High-throughput

0.457

High

981732

REL
Proto-oncogene c-Rel

1

12

High-throughput

0.457

High

1295542

CC136
Coiled-coil domain-containing protein 136

1

20

High-throughput

0.439

High

831704

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

1222761

IHO1
Interactor of HORMAD1 protein 1

3

0

High-throughput

0.352

High

63458

MET15
12S rRNA N4-methylcytidine

2

0

High-throughput

0.316

High

1120648

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

1198323

K1328
Protein hinderin

2

0

High-throughput

0.316

High

1223783

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

1237272

BEND7
BEN domain-containing protein 7

2

0

High-throughput

0.316

High

1238898

CBY2
Protein chibby homolog 2

2

0

High-throughput

0.316

High

1238923

SAXO5
Stabilizer of axonemal microtubules 5

2

0

High-throughput

0.316

High

1254738

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

1293359

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.316

High

1335916

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

1291989

BSCL2
Seipin

1

0

High-throughput

0.279

Low

1335872

Q9HC85
Metastasis related protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024