Protein: UPK2
Uroplakin-2 (UP2) (Uroplakin II) (UPII)

Gene: UPK2
Organism: Homo sapiens
Interactions: 228
UniProt ID: O00526

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0016324 - apical plasma membrane
GO:0030855 - epithelial cell differentiation
GO:0070062 - extracellular exosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

139159

RENR
Renin receptor

3

0

High-throughput

0.620

High

132536

UPK1A
Uroplakin-1a

1

1

Small-scale

0.618

High

139150

TNF11
Tumor necrosis factor ligand superfamily member 11

2

1

High-throughput

0.606

High

139153

TMPS2
Transmembrane protease serine 2

2

2

High-throughput

0.606

High

139155

TNF14
Tumor necrosis factor ligand superfamily member 14

2

1

High-throughput

0.606

High

139170

HEPS
Serine protease hepsin

2

2

High-throughput

0.606

High

139171

ASGR2
Asialoglycoprotein receptor 2

2

2

High-throughput

0.606

High

139175

FCGR1
High affinity immunoglobulin gamma Fc receptor I

2

1

High-throughput

0.606

High

139176

FCG2A
Low affinity immunoglobulin gamma Fc region receptor II-a

2

2

High-throughput

0.606

High

139192

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

2

2

High-throughput

0.606

High

139260

AGRG3
Adhesion G protein-coupled receptor G3

2

6

High-throughput

0.606

High

139269

KI3L3
Killer cell immunoglobulin-like receptor 3DL3

2

2

High-throughput

0.606

High

139305

CLC7A
C-type lectin domain family 7 member A

2

2

High-throughput

0.606

High

139231

AB17B
Alpha/beta hydrolase domain-containing protein 17B

2

1

High-throughput

0.601

High

139319

CNNM2
Metal transporter CNNM2

2

2

High-throughput

0.601

High

139355

PCDB2
Protocadherin beta-2

2

16

High-throughput

0.601

High

50070

S22AN
Solute carrier family 22 member 23

2

0

High-throughput

0.580

High

139165

CLD7
Claudin-7

2

0

High-throughput

0.580

High

139168

HG2A
HLA class II histocompatibility antigen gamma chain

2

0

High-throughput

0.580

High

139201

MYPR
Myelin proteolipid protein

2

0

High-throughput

0.580

High

139210

SMAGP
Small cell adhesion glycoprotein

2

0

High-throughput

0.580

High

139225

TTMP
TPA-induced transmembrane protein

2

0

High-throughput

0.580

High

139243

BTNL9
Butyrophilin-like protein 9

2

0

High-throughput

0.580

High

139273

STML3
Stomatin-like protein 3

2

0

High-throughput

0.580

High

139298

GPA33
Cell surface A33 antigen

2

0

High-throughput

0.580

High

139329

ITM2C
Integral membrane protein 2C

2

0

High-throughput

0.580

High

139185

IL6RB
Interleukin-6 receptor subunit beta

2

0

High-throughput

0.576

High

139196

MMP15
Matrix metalloproteinase-15

2

0

High-throughput

0.576

High

139203

ASIC1
Acid-sensing ion channel 1

2

0

High-throughput

0.576

High

139215

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.576

High

139217

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

2

0

High-throughput

0.576

High

139274

TIP
T-cell immunomodulatory protein

2

0

High-throughput

0.576

High

139297

SORT
Sortilin

2

0

High-throughput

0.576

High

139306

TMM59
Transmembrane protein 59

2

0

High-throughput

0.576

High

139309

KPCD2
Serine/threonine-protein kinase D2

2

0

High-throughput

0.576

High

139311

SEM4C
Semaphorin-4C

2

0

High-throughput

0.576

High

139317

ANTR1
Anthrax toxin receptor 1

2

0

High-throughput

0.576

High

139365

BACE2
Beta-secretase 2

2

0

High-throughput

0.576

High

139200

FCGRN
IgG receptor FcRn large subunit p51

2

3

High-throughput

0.553

High

139247

CL17A
C-type lectin domain family 17, member A

2

2

High-throughput

0.553

High

139259

AMGO1
Amphoterin-induced protein 1

2

1

High-throughput

0.553

High

139162

IPO13
Importin-13

2

1

High-throughput

0.549

High

139282

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

2

3

High-throughput

0.549

High

139368

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

2

4

High-throughput

0.549

High

139369

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

2

4

High-throughput

0.549

High

139179

TSN8
Tetraspanin-8

1

0

High-throughput

0.546

High

139157

NRP2
Neuropilin-2

1

1

High-throughput

0.536

High

139163

AGRL1
Adhesion G protein-coupled receptor L1

1

6

High-throughput

0.536

High

139173

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.536

High

139177

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

3

High-throughput

0.536

High

139180

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

1

High-throughput

0.536

High

139182

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

2

High-throughput

0.536

High

139194

AGRE5
Adhesion G protein-coupled receptor E5

1

6

High-throughput

0.536

High

139195

BCAM
Basal cell adhesion molecule

1

2

High-throughput

0.536

High

139198

AT12A
Potassium-transporting ATPase alpha chain 2

1

2

High-throughput

0.536

High

139207

PCDH1
Protocadherin-1

1

18

High-throughput

0.536

High

139213

CD166
CD166 antigen

1

2

High-throughput

0.536

High

139219

PRSS8
Prostasin

1

2

High-throughput

0.536

High

139228

AGRF1
Adhesion G-protein coupled receptor F1

1

6

High-throughput

0.536

High

139234

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

1

1

High-throughput

0.536

High

139240

CNNM4
Metal transporter CNNM4

1

2

High-throughput

0.536

High

139250

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.536

High

139252

SV2A
Synaptic vesicle glycoprotein 2A

1

1

High-throughput

0.536

High

139254

MON2
Protein MON2 homolog

1

4

High-throughput

0.536

High

139257

AGRG6
Adhesion G-protein coupled receptor G6

1

6

High-throughput

0.536

High

139323

PCDH9
Protocadherin-9

1

18

High-throughput

0.536

High

139325

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

7

High-throughput

0.536

High

139336

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

1

1

High-throughput

0.536

High

139337

PCD10
Protocadherin-10

1

18

High-throughput

0.536

High

139362

PCDGB
Protocadherin gamma-A11

1

17

High-throughput

0.536

High

61063

T131L
Transmembrane protein 131-like

1

0

High-throughput

0.513

High

139164

UCP5
Brain mitochondrial carrier protein 1

1

0

High-throughput

0.513

High

139186

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

High-throughput

0.513

High

139189

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.513

High

139208

DDR1
Epithelial discoidin domain-containing receptor 1

1

0

High-throughput

0.513

High

139221

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.513

High

139238

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

0

High-throughput

0.513

High

139270

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.513

High

139272

NLGN2
Neuroligin-2

1

0

High-throughput

0.513

High

139277

MOT10
Monocarboxylate transporter 10

1

0

High-throughput

0.513

High

139279

S20A1
Sodium-dependent phosphate transporter 1

1

0

High-throughput

0.513

High

139291

KIRR1
Kin of IRRE-like protein 1

1

0

High-throughput

0.513

High

139308

ABCA2
ATP-binding cassette sub-family A member 2

1

0

High-throughput

0.513

High

139314

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

139321

RHOF
Rho-related GTP-binding protein RhoF

1

0

High-throughput

0.513

High

139327

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.513

High

139340

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.513

High

139353

LRP12
Low-density lipoprotein receptor-related protein 12

1

0

High-throughput

0.513

High

139151

TM9S1
Transmembrane 9 superfamily member 1

1

2

High-throughput

0.489

High

139156

XPOT
Exportin-T

1

1

High-throughput

0.489

High

139160

C1QRF
C1q-related factor

1

1

High-throughput

0.489

High

139261

C1QL4
Complement C1q-like protein 4

1

1

High-throughput

0.489

High

139283

TM9S4
Transmembrane 9 superfamily member 4

1

2

High-throughput

0.489

High

139284

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.489

High

139285

GLT14
Polypeptide N-acetylgalactosaminyltransferase 14

1

1

High-throughput

0.489

High

139299

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.489

High

139300

CSTN3
Calsyntenin-3

1

16

High-throughput

0.489

High

139318

AT133
Polyamine-transporting ATPase 13A3

1

3

High-throughput

0.489

High

139326

TM9S3
Transmembrane 9 superfamily member 3

1

2

High-throughput

0.489

High

139149

UPK2
Uroplakin-2

1

0

Small-scale

0.480

High

116989

J3KQ12
Seipin

1

1

High-throughput

0.470

High

139166

GTR10
Solute carrier family 2, facilitated glucose transporter member 10

1

1

High-throughput

0.445

High

139169

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.445

High

139205

AT2C1
Calcium-transporting ATPase type 2C member 1

1

2

High-throughput

0.445

High

139206

ATP7A
Copper-transporting ATPase 1

1

2

High-throughput

0.445

High

139214

GAS6
Growth arrest-specific protein 6

1

1

High-throughput

0.445

High

139245

PCD23
Protocadherin-23

1

9

High-throughput

0.445

High

139256

GALT7
N-acetylgalactosaminyltransferase 7

1

1

High-throughput

0.445

High

139263

WDFY3
WD repeat and FYVE domain-containing protein 3

1

2

High-throughput

0.445

High

139276

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

1

High-throughput

0.445

High

139287

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

1

High-throughput

0.445

High

139295

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

1

2

High-throughput

0.445

High

139320

AGRL3
Adhesion G protein-coupled receptor L3

1

6

High-throughput

0.445

High

139324

PCD18
Protocadherin-18

1

19

High-throughput

0.445

High

139328

IL1AP
Interleukin-1 receptor accessory protein

1

1

High-throughput

0.445

High

139332

CNNM1
Metal transporter CNNM1

1

2

High-throughput

0.445

High

139343

PCDB8
Protocadherin beta-8

1

17

High-throughput

0.445

High

139344

PCDBA
Protocadherin beta-10

1

16

High-throughput

0.445

High

139345

PCDGK
Protocadherin gamma-C3

1

14

High-throughput

0.445

High

139346

PCDGG
Protocadherin gamma-B4

1

18

High-throughput

0.445

High

139347

PCDA6
Protocadherin alpha-6

1

14

High-throughput

0.445

High

139348

PCDA4
Protocadherin alpha-4

1

15

High-throughput

0.445

High

139349

PCDAC
Protocadherin alpha-12

1

16

High-throughput

0.445

High

139354

PCDB5
Protocadherin beta-5

1

15

High-throughput

0.445

High

139356

PCDBE
Protocadherin beta-14

1

15

High-throughput

0.445

High

139357

PCDBD
Protocadherin beta-13

1

16

High-throughput

0.445

High

139358

PCDBC
Protocadherin beta-12

1

16

High-throughput

0.445

High

139359

PCDBB
Protocadherin beta-11

1

16

High-throughput

0.445

High

139360

PCDGH
Protocadherin gamma-B5

1

18

High-throughput

0.445

High

139361

PCDGD
Protocadherin gamma-B1

1

17

High-throughput

0.445

High

139363

PCDA8
Protocadherin alpha-8

1

14

High-throughput

0.445

High

139364

PCDC2
Protocadherin alpha-C2

1

15

High-throughput

0.445

High

139286

BSCL2
Seipin

1

1

High-throughput

0.439

High

139158

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.426

High

139172

FURIN
Furin

1

0

High-throughput

0.426

High

139178

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

0

High-throughput

0.426

High

139187

PI4KA
Phosphatidylinositol 4-kinase alpha

1

0

High-throughput

0.426

High

139218

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.426

High

139220

MA2A1
Alpha-mannosidase 2

1

0

High-throughput

0.426

High

139224

PKHG4
Puratrophin-1

1

0

High-throughput

0.426

High

139266

ARG28
Rho guanine nucleotide exchange factor 28

1

0

High-throughput

0.426

High

139292

SPTCS
Spatacsin

1

0

High-throughput

0.426

High

139301

MXRA8
Matrix remodeling-associated protein 8

1

0

High-throughput

0.426

High

139331

C42S2
CDC42 small effector protein 2

1

0

High-throughput

0.426

High

139350

NAC2
Sodium/calcium exchanger 2

1

0

High-throughput

0.426

High

139352

TLR6
Toll-like receptor 6

1

0

High-throughput

0.426

High

139190

MAGA6
Melanoma-associated antigen 6

1

1

High-throughput

0.407

High

139191

MAGAC
Melanoma-associated antigen 12

1

1

High-throughput

0.407

High

139223

WDR81
WD repeat-containing protein 81

1

1

High-throughput

0.407

High

139230

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

1

3

High-throughput

0.407

High

139235

ZFY26
Zinc finger FYVE domain-containing protein 26

1

1

High-throughput

0.407

High

139249

SAMC
Mitochondrial S-adenosylmethionine carrier protein

1

1

High-throughput

0.407

High

139281

RUFY2
RUN and FYVE domain-containing protein 2

1

1

High-throughput

0.407

High

139275

FNDC9
Fibronectin type III domain-containing protein 9

2

0

High-throughput

0.316

High

139280

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

0

High-throughput

0.316

High

139293

RN170
E3 ubiquitin-protein ligase RNF170

2

0

High-throughput

0.316

High

139304

T106C
Transmembrane protein 106C

2

0

High-throughput

0.316

High

139315

LIME1
Lck-interacting transmembrane adapter 1

2

0

High-throughput

0.316

High

139222

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

2

0

High-throughput

0.313

High

139229

DIK1A
Divergent protein kinase domain 1A

2

0

High-throughput

0.313

High

139232

RN213
E3 ubiquitin-protein ligase RNF213

2

0

High-throughput

0.313

High

139233

SE1L3
Protein sel-1 homolog 3

2

0

High-throughput

0.313

High

139237

HEAT6
HEAT repeat-containing protein 6

2

0

High-throughput

0.313

High

139239

TTC27
Tetratricopeptide repeat protein 27

2

0

High-throughput

0.313

High

139289

INT4
Integrator complex subunit 4

2

0

High-throughput

0.313

High

139294

ARL5B
ADP-ribosylation factor-like protein 5B

2

0

High-throughput

0.313

High

139302

ADPGK
ADP-dependent glucokinase

2

0

High-throughput

0.313

High

139307

FACD2
Fanconi anemia group D2 protein

2

0

High-throughput

0.313

High

139313

LMA2L
VIP36-like protein

2

0

High-throughput

0.313

High

139268

KASH5
Protein KASH5

1

0

High-throughput

0.299

High

139181

CTNA2
Catenin alpha-2

1

0

High-throughput

0.279

Low

139183

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.279

Low

139184

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.279

Low

139204

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

139216

UBE3C
Ubiquitin-protein ligase E3C

1

0

High-throughput

0.279

Low

139226

MKS3
Meckelin

1

0

High-throughput

0.279

Low

139241

INT5
Integrator complex subunit 5

1

0

High-throughput

0.279

Low

139251

INT8
Integrator complex subunit 8

1

0

High-throughput

0.279

Low

139258

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

139265

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.279

Low

139296

GCP5
Gamma-tubulin complex component 5

1

0

High-throughput

0.279

Low

139310

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

0

High-throughput

0.279

Low

139312

INT2
Integrator complex subunit 2

1

0

High-throughput

0.279

Low

139316

HEAT1
HEAT repeat-containing protein 1

1

0

High-throughput

0.279

Low

139334

INT7
Integrator complex subunit 7

1

0

High-throughput

0.279

Low

139335

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.279

Low

139339

IPO11
Importin-11

1

0

High-throughput

0.279

Low

139351

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

High-throughput

0.279

Low

139366

ORNT1
Mitochondrial ornithine transporter 1

1

0

High-throughput

0.279

Low

139167

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.251

Low

139197

VMAT1
Chromaffin granule amine transporter

1

0

High-throughput

0.251

Low

139367

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

0

High-throughput

0.251

Low

139174

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.249

Low

139199

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

Small-scale

0.249

Low

48121

IFT56
Intraflagellar transport protein 56

1

0

High-throughput

0.232

Low

62203

DEN11
DENN domain-containing protein 11

1

0

High-throughput

0.232

Low

139152

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.232

Low

139154

RA51C
DNA repair protein RAD51 homolog 3

1

0

High-throughput

0.232

Low

139161

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.232

Low

139188

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

139193

ACDSB
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

139202

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.232

Low

139209

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.232

Low

139211

WASC5
WASH complex subunit 5

1

0

High-throughput

0.232

Low

139212

ATM
Serine-protein kinase ATM

1

0

High-throughput

0.232

Low

139227

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

139236

CRBG3
Very large A-kinase anchor protein

1

0

High-throughput

0.232

Low

139242

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.232

Low

139244

LRRN1
Leucine-rich repeat neuronal protein 1

1

0

High-throughput

0.232

Low

139246

THADA
tRNA

1

0

High-throughput

0.232

Low

139248

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

0

High-throughput

0.232

Low

139253

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.232

Low

139255

CF120
UPF0669 protein C6orf120

1

0

High-throughput

0.232

Low

139262

ZNG1B
Zinc-regulated GTPase metalloprotein activator 1B

1

0

High-throughput

0.232

Low

139264

FCSK
L-fucose kinase

1

0

High-throughput

0.232

Low

139267

INT1
Integrator complex subunit 1

1

0

High-throughput

0.232

Low

139271

MROH1
Maestro heat-like repeat-containing protein family member 1

1

0

High-throughput

0.232

Low

139278

TM263
Transmembrane protein 263

1

0

High-throughput

0.232

Low

139288

SGSM3
Small G protein signaling modulator 3

1

0

High-throughput

0.232

Low

139290

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.232

Low

139303

TCAB1
Telomerase Cajal body protein 1

1

0

High-throughput

0.232

Low

139322

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.232

Low

139330

AAAS
Aladin

1

0

High-throughput

0.232

Low

139333

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.232

Low

139338

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.232

Low

139341

FBX2
F-box only protein 2

1

0

High-throughput

0.232

Low

139342

FBXL3
F-box/LRR-repeat protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025