Protein: DCP2
m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc)

Gene: DCP2
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q8IU60

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000290 - deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0000932 - P-body
GO:0004534 - 5'-3' RNA exonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1306924

DCP1A
mRNA-decapping enzyme 1A

15

3

Small-scale

0.987

High

1306898

DCP1B
mRNA-decapping enzyme 1B

7

3

Small-scale

0.965

High

1306925

PNRC2
Proline-rich nuclear receptor coactivator 2

3

0

Small-scale

0.796

High

1241464

EDC4
Enhancer of mRNA-decapping protein 4

10

2

Small-scale

0.757

High

1306910

EDC3
Enhancer of mRNA-decapping protein 3

6

4

Small-scale

0.732

High

1306908

RENT1
Regulator of nonsense transcripts 1

3

1

Small-scale

0.667

High

1107886

SQSTM
Sequestosome-1

4

0

High-throughput

0.664

High

855674

CRK
Adapter molecule crk

3

1

High-throughput

0.650

High

156306

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

3

0

High-throughput

0.638

High

944825

PCBP3
Poly(rC)-binding protein 3

3

0

High-throughput

0.638

High

1051795

EF1A2
Elongation factor 1-alpha 2

3

0

High-throughput

0.638

High

1306936

COL10
Collectin-10

3

0

High-throughput

0.638

High

791508

SYUA
Alpha-synuclein

3

0

Small-scale

0.622

High

1125993

LRC32
Transforming growth factor beta activator LRRC32

2

0

High-throughput

0.602

High

684300

DDX6
Probable ATP-dependent RNA helicase DDX6

2

2

Small-scale

0.584

High

959203

ABCE1
ATP-binding cassette sub-family E member 1

2

1

Small-scale

0.584

High

1306895

DCP2
m7GpppN-mRNA hydrolase

1

1

Small-scale

0.575

High

1306922

RENT2
Regulator of nonsense transcripts 2

2

0

Small-scale

0.575

High

366250

FA9
Coagulation factor IX

2

1

High-throughput

0.574

High

623420

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

Small-scale

0.537

High

483141

CLCA
Clathrin light chain A

1

1

High-throughput

0.536

High

483362

CLCB
Clathrin light chain B

1

1

High-throughput

0.536

High

688274

TTP
mRNA decay activator protein ZFP36

1

1

Small-scale

0.536

High

855898

CRKL
Crk-like protein

1

1

High-throughput

0.536

High

530044

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

650842

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.513

High

799968

COIL
Coilin

1

0

High-throughput

0.513

High

957435

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.513

High

1306900

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1306902

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.513

High

1306905

PPR35
Protein phosphatase 1 regulatory subunit 35

1

0

High-throughput

0.513

High

1306912

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

1306914

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.513

High

839311

MTOR
Serine/threonine-protein kinase mTOR

1

3

Small-scale

0.501

High

633736

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.486

High

1122748

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.486

High

1306931

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.486

High

317460

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

1

High-throughput

0.479

High

575158

IDE
Insulin-degrading enzyme

1

1

High-throughput

0.479

High

1024681

VIGLN
Vigilin

1

2

High-throughput

0.479

High

1054306

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

1

High-throughput

0.479

High

1059231

TISB
mRNA decay activator protein ZFP36L1

1

1

Small-scale

0.479

High

1287091

PATL1
Protein PAT1 homolog 1

1

3

Small-scale

0.479

High

1306934

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

327615

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

335626

AGM1
Phosphoacetylglucosamine mutase

1

0

High-throughput

0.458

High

359685

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

401097

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

467935

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

0

High-throughput

0.458

High

589086

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

606013

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.458

High

687692

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

0

High-throughput

0.458

High

768585

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

831023

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

834339

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.458

High

966571

1433G
14-3-3 protein gamma

1

0

High-throughput

0.458

High

992608

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

1140218

DPOD3
DNA polymerase delta subunit 3

1

0

High-throughput

0.458

High

1191869

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.458

High

1217788

ANGE2
Protein angel homolog 2

1

0

High-throughput

0.458

High

1244553

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1275547

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

Small-scale

0.458

High

1306897

TRM2A
tRNA

1

0

High-throughput

0.458

High

1306901

RHG18
Rho GTPase-activating protein 18

1

0

High-throughput

0.458

High

1306903

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

High-throughput

0.458

High

1306907

DDX17
Probable ATP-dependent RNA helicase DDX17

1

0

Small-scale

0.458

High

1306909

KPBB
Phosphorylase b kinase regulatory subunit beta

1

0

High-throughput

0.458

High

1306913

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1306916

AP1M1
AP-1 complex subunit mu-1

1

0

High-throughput

0.458

High

1306917

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1306918

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

1306919

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1306920

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1306921

ELP3
Elongator complex protein 3

1

0

High-throughput

0.458

High

1306926

INT7
Integrator complex subunit 7

1

0

High-throughput

0.458

High

1306928

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.458

High

1306932

FBX3
F-box only protein 3

1

0

High-throughput

0.458

High

1306933

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

1306935

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

1306899

XRN1
5'-3' exoribonuclease 1

1

2

Small-scale

0.445

High

1306915

GTPB2
GTP-binding protein 2

1

1

High-throughput

0.437

High

3677

NBDY
Negative regulator of P-body association

1

0

Small-scale

0.426

High

341982

CEP43
Centrosomal protein 43

1

0

High-throughput

0.426

High

1010067

DLK1
Protein delta homolog 1

1

0

High-throughput

0.426

High

1254211

ARHGI
Rho guanine nucleotide exchange factor 18

1

0

High-throughput

0.426

High

1306929

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

Small-scale

0.426

High

1306896

FBX16
F-box only protein 16

1

1

High-throughput

0.407

High

1306923

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

276151

NIPS2
Protein NipSnap homolog 2

2

0

High-throughput

0.318

High

327070

NXPH3
Neurexophilin-3

2

0

High-throughput

0.318

High

1306930

GGT7
Glutathione hydrolase 7

2

0

High-throughput

0.318

High

342612

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

630171

ACM3
Muscarinic acetylcholine receptor M3

1

0

High-throughput

0.279

Low

1128916

I13R2
Interleukin-13 receptor subunit alpha-2

1

0

High-throughput

0.279

Low

1142499

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.279

Low

1160918

PRSS8
Prostasin

1

0

High-throughput

0.279

Low

1306904

LY65B
Lymphocyte antigen 6 complex locus protein G5b

1

0

High-throughput

0.279

Low

1306906

FNDC8
Fibronectin type III domain-containing protein 8

1

0

High-throughput

0.279

Low

800218

VKGC
Vitamin K-dependent gamma-carboxylase

1

0

High-throughput

0.249

Low

1241070

ARMX5
Armadillo repeat-containing X-linked protein 5

1

0

High-throughput

0.249

Low

1306911

SFXN2
Sideroflexin-2

1

0

High-throughput

0.249

Low

1306927

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

0

High-throughput

0.249

Low

516685

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low

841563

I12R1
Interleukin-12 receptor subunit beta-1

1

0

High-throughput

0.232

Low

1288318

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025