Protein: HIPPO
Serine/threonine-protein kinase hippo (EC 2.7.11.1) (Drosophila homolog of MST1 and MST2) (STE20-like kinase MST) (dMST)

Gene: HIPPO, hpo
Organism: Drosophila melanogaster
Interactions: 83
UniProt ID: Q8T0S6

Gene Ontology (top 5):
GO:0001654 - eye development
GO:0001745 - compound eye morphogenesis
GO:0002011 - morphogenesis of an epithelial sheet
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1249829

HIPPO
Serine/threonine-protein kinase hippo

8

16

Small-scale

0.973

High

1249834

WARTS
Serine/threonine-protein kinase Warts

8

18

Small-scale

0.968

High

1249857

Q9W5R5
LD47843p

3

20

Small-scale

0.839

High

1249838

SAV
Scaffold protein salvador

24

20

Small-scale

0.768

High

1249832

TRC
Serine/threonine-protein kinase tricornered

1

17

Small-scale

0.747

High

1249837

Q9VCQ7
LD40758p

7

17

Small-scale

0.743

High

442965

RAP1
Ras-related protein Rap1

1

20

Small-scale

0.724

High

1249830

MOB1
MOB kinase activator-like 1

4

20

Small-scale

0.683

High

991229

EXPA
Protein expanded

3

19

Small-scale

0.661

High

527259

MODU
DNA-binding protein modulo

1

5

High-throughput

0.656

High

1249628

KIPF
Zinc finger protein kipf

1

5

High-throughput

0.656

High

112704

M9NE33
non-specific serine/threonine protein kinase

1

20

Small-scale

0.647

High

619891

PP2A
Serine/threonine-protein phosphatase PP2A

3

20

Small-scale

0.640

High

1097058

DIAP1
Death-associated inhibitor of apoptosis 1

3

5

Small-scale

0.635

High

1182559

Q7KUZ5
Cyclin D, isoform D

1

7

High-throughput

0.621

High

1249157

Q8SYC0
Bruno 1, isoform D

1

8

High-throughput

0.621

High

90540

E1JGN0
non-specific serine/threonine protein kinase

1

19

Small-scale

0.618

High

585762

CI
Transcriptional activator cubitus interruptus

1

12

Small-scale

0.618

High

734198

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

1

17

Small-scale

0.618

High

1099221

Q24590
Tumor suppressor

1

20

Small-scale

0.618

High

1155103

Q6NPA6
non-specific serine/threonine protein kinase

1

19

Small-scale

0.618

High

1249831

GIT
ARF GTPase-activating protein Git

1

19

Small-scale

0.618

High

1249850

RAN
GTP-binding nuclear protein Ran

1

17

High-throughput

0.618

High

780878

RS18
Small ribosomal subunit protein uS13

2

2

High-throughput

0.600

High

333215

O97468
TAR-binding protein

1

13

High-throughput

0.590

High

618456

CDK2
Cyclin-dependent kinase 2

1

13

High-throughput

0.590

High

1179443

Q7K306
Cyclin-dependent kinase 4, isoform A

1

10

High-throughput

0.590

High

1213882

Q8IP90
Bruno 1, isoform B

1

8

High-throughput

0.590

High

1249849

Q9VXM1
LD22957p

1

7

High-throughput

0.590

High

1249847

DEFI8
Differentially expressed in FDCP 8 homolog

1

17

High-throughput

0.587

High

87981

D3DML3
Connector of kinase to AP-1, isoform E

2

20

Small-scale

0.584

High

1115138

YAP1
Transcriptional coactivator yorkie

2

20

Small-scale

0.584

High

1215288

Q8IRD5
AT25231p

2

12

Small-scale

0.584

High

1249844

Q9VQW7
Echinoid, isoform A

1

1

Small-scale

0.553

High

1249858

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.549

High

1249841

Q9VGU4
FI02822p

1

8

High-throughput

0.536

High

1249843

FGOP2
FGFR1 oncogene partner 2 homolog

2

14

Small-scale

0.533

High

186211

GBLP
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.508

High

1249833

Q9U6R9
Gamma-soluble NSF attachment protein

1

8

High-throughput

0.508

High

1249835

Q9VB23
Serine/threonine protein phosphatase 2A regulatory subunit

1

6

High-throughput

0.508

High

1249842

EF1D
Probable elongation factor 1-delta

1

1

High-throughput

0.508

High

1249851

FBXW7
F-box/WD repeat-containing protein 7

1

20

High-throughput

0.508

High

55949

A1ZBE0
Major facilitator superfamily transporter 15, isoform B

1

0

High-throughput

0.486

High

954674

L259
Probable multidrug resistance-associated protein lethal(2)03659

1

0

High-throughput

0.486

High

1187254

Q7YU15
Klarsicht, isoform B

1

1

High-throughput

0.481

High

54106

A1Z9E3
Elongation factor Tu

1

3

High-throughput

0.479

High

91161

E3CTP7
Epidermal growth factor receptor pathway substrate clone 15, isoform D

1

5

High-throughput

0.479

High

112579

M9ND00
Dynamin associated protein 160, isoform D

1

20

High-throughput

0.479

High

115752

M9PGB1
Rho-type guanine nucleotide exchange factor, isoform G

1

20

Small-scale

0.479

High

611093

ATC1
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

1

3

High-throughput

0.479

High

612651

DDX6
ATP-dependent RNA helicase me31b

1

11

High-throughput

0.479

High

897450

ARF1
ADP-ribosylation factor 1

1

10

High-throughput

0.479

High

1098268

MERH
Moesin/ezrin/radixin homolog 2

1

14

Small-scale

0.479

High

1178598

MOB4
MOB kinase activator-like 4

1

20

Small-scale

0.479

High

1213949

Q8IPC3
ubiquitinyl hydrolase 1

1

2

Small-scale

0.479

High

1249839

Q9VDE3
LD08669p

1

20

Small-scale

0.479

High

1249840

KIBRA
Protein kibra

1

20

Small-scale

0.479

High

1249852

Q9W0H2
HECT and RLD domain containing E3 ubiquitin ligase 4, isoform A

1

20

Small-scale

0.479

High

1249855

Q9W392
T-complex protein 1 subunit beta

1

20

High-throughput

0.479

High

56390

A1ZBW6
Uncharacterized protein, isoform A

1

3

High-throughput

0.464

High

950395

H4
Histone H4

1

3

High-throughput

0.464

High

1249856

Q9W5E8
Uncharacterized protein, isoform A

1

20

High-throughput

0.464

High

81140

B7YZT5
Phospholipase

1

0

High-throughput

0.460

High

1249853

Q9W0Q4
Klarsicht, isoform A

1

1

High-throughput

0.457

High

1123725

Q59DN5
FI18025p1

1

12

High-throughput

0.439

High

1182426

Q7KUK4
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

1214537

Q8IQ71
Dikar, isoform C

1

15

High-throughput

0.439

High

1249845

Q9VT68
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.439

High

1096986

DS
Protein dachsous

1

3

High-throughput

0.437

High

1249846

Q9VT69
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase

1

1

High-throughput

0.417

High

1249859

AMOS
Basic helix-loop-helix transcription factor amos

1

4

High-throughput

0.417

High

878841

RS20
Small ribosomal subunit protein uS10

2

0

High-throughput

0.310

High

51126

NUP75
Nuclear pore complex protein Nup75

1

0

High-throughput

0.265

Low

524735

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.265

Low

620726

DISC
Protein disconnected

1

0

High-throughput

0.265

Low

1001184

Q0E9B7
DNAation factor-related protein 3, isoform A

1

0

High-throughput

0.265

Low

1118641

Q4V5M2
IP06990p

1

0

High-throughput

0.265

Low

1248537

Q8SX23
RE67967p

1

0

High-throughput

0.265

Low

1248671

Q8SX89
Kugelkern, isoform A

1

0

High-throughput

0.265

Low

1249836

Q9VBX5
Tubulin--tyrosine ligase-like protein 5

1

0

High-throughput

0.265

Low

1249848

Q9VUP0
AT03386p

1

0

High-throughput

0.265

Low

1249854

Q9W1A7
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024