Protein: SC5A6
Sodium-dependent multivitamin transporter (Na(+)-dependent multivitamin transporter) (hSMVT) (Solute carrier family 5 member 6)

Gene: SC5A6, SLC5A6
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9Y289

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0006768 - biotin metabolic process
GO:0006814 - sodium ion transport
GO:0008523 - sodium-dependent multivitamin transmembrane transporter activity
GO:0009925 - basal plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1212247

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

2

1

High-throughput

0.611

High

845867

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.586

High

923449

SC5A3
Sodium/myo-inositol cotransporter

1

6

High-throughput

0.575

High

397257

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

125671

LEG9
Galectin-9

2

3

High-throughput

0.558

High

477183

ACM5
Muscarinic acetylcholine receptor M5

1

1

High-throughput

0.541

High

190521

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.536

High

228116

PM34
Peroxisomal membrane protein PMP34

1

1

High-throughput

0.536

High

248638

FADS1
Acyl-CoA

1

1

High-throughput

0.536

High

609844

LEG3
Galectin-3

1

3

High-throughput

0.536

High

669086

FPR2
N-formyl peptide receptor 2

1

5

High-throughput

0.536

High

699268

CALX
Calnexin

1

2

High-throughput

0.536

High

867692

GPR12
G-protein coupled receptor 12

1

3

High-throughput

0.536

High

1041380

CAV1
Caveolin-1

1

2

High-throughput

0.536

High

1108473

MTX1
Metaxin-1

1

2

High-throughput

0.536

High

1231490

ATLA3
Atlastin-3

1

1

High-throughput

0.536

High

1240595

MBOA5
Lysophospholipid acyltransferase 5

1

2

High-throughput

0.536

High

1291923

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

3

High-throughput

0.536

High

1322844

ORML3
ORM1-like protein 3

1

3

High-throughput

0.536

High

1348823

S35G2
Solute carrier family 35 member G2

1

2

High-throughput

0.536

High

1356610

CHPT1
Cholinephosphotransferase 1

1

2

High-throughput

0.536

High

1381411

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

1

High-throughput

0.536

High

1428179

YIPF3
Protein YIPF3

1

2

High-throughput

0.536

High

1448045

PXMP2
Peroxisomal membrane protein 2

1

2

High-throughput

0.536

High

1401959

ERBIN
Erbin

1

1

Small-scale

0.527

High

216029

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.513

High

403240

APOB
Apolipoprotein B-100

1

0

High-throughput

0.513

High

1060312

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

0

High-throughput

0.513

High

1217402

AB17B
Alpha/beta hydrolase domain-containing protein 17B

1

0

High-throughput

0.513

High

1228789

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

High-throughput

0.513

High

1238905

MFS12
Major facilitator superfamily domain-containing protein 12

1

0

High-throughput

0.513

High

1259232

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

1

0

High-throughput

0.513

High

1295456

C2CD5
C2 domain-containing protein 5

1

0

High-throughput

0.513

High

1317093

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

0

High-throughput

0.513

High

1324887

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1350011

SPPL3
Signal peptide peptidase-like 3

1

0

High-throughput

0.513

High

1361967

BSND
Barttin

1

0

High-throughput

0.513

High

1387244

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.513

High

1414425

G6PC3
Glucose-6-phosphatase 3

1

0

High-throughput

0.513

High

1429313

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.513

High

1459564

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.513

High

1204230

PDZ11
PDZ domain-containing protein 11

1

0

Small-scale

0.506

High

1335826

GALT6
Polypeptide N-acetylgalactosaminyltransferase 6

1

1

High-throughput

0.494

High

732863

GLPK
Glycerol kinase

1

1

High-throughput

0.489

High

1198955

ORML2
ORM1-like protein 2

1

3

High-throughput

0.489

High

1204966

MTX3
Metaxin-3

1

2

High-throughput

0.489

High

1329529

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

1

High-throughput

0.489

High

1350639

SFXN5
Sideroflexin-5

1

1

High-throughput

0.489

High

1382981

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.489

High

1388024

RSPRY
RING finger and SPRY domain-containing protein 1

1

2

High-throughput

0.489

High

1389731

TV23C
Golgi apparatus membrane protein TVP23 homolog C

1

1

High-throughput

0.489

High

1428523

ELOV4
Very long chain fatty acid elongase 4

1

1

High-throughput

0.489

High

1454000

ORML1
ORM1-like protein 1

1

3

High-throughput

0.489

High

508857

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

218977

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

71070

PDZ1P
Putative PDZ domain-containing protein PDZK1P1

1

1

High-throughput

0.445

High

948967

CD81
CD81 antigen

1

4

High-throughput

0.445

High

414879

P53
Cellular tumor antigen p53

1

1

High-throughput

0.437

High

1367623

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

380198

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

506685

GPHRB
Golgi pH regulator B

1

4

High-throughput

0.407

High

1450859

TM38B
Trimeric intracellular cation channel type B

2

0

High-throughput

0.313

High

975570

SELT
Thioredoxin reductase-like selenoprotein T

1

0

High-throughput

0.279

Low

1052385

RN5A
2-5A-dependent ribonuclease

1

0

High-throughput

0.279

Low

1239837

MZT2B
Mitotic-spindle organizing protein 2B

1

0

High-throughput

0.279

Low

1243261

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.279

Low

1431693

ARV1
Protein ARV1

1

0

High-throughput

0.279

Low

1458927

MTFP1
Mitochondrial fission process protein 1

1

0

High-throughput

0.279

Low

294547

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1005258

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1197759

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1203100

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

1293214

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1459357

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1244721

TTC33
Tetratricopeptide repeat protein 33

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025