Protein: DPOG1
DNA polymerase subunit gamma-1 (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (5'-deoxyribose-phosphate lyase) (EC 4.2.99.-) (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha)

Gene: DPOG1, POLG
Organism: Homo sapiens
Interactions: 107
UniProt ID: P54098

Gene Ontology (top 5):
GO:0000262 - mitochondrial chromosome
GO:0002020 - protease binding
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003887 - DNA-directed DNA polymerase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926136

DPOG2
DNA polymerase subunit gamma-2

7

0

Small-scale

0.922

High

926089

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

926114

MGME1
Mitochondrial genome maintenance exonuclease 1

3

0

High-throughput

0.634

High

225190

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

2

0

High-throughput

0.602

High

275270

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

349660

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

361620

OTC
Ornithine transcarbamylase, mitochondrial

2

0

High-throughput

0.602

High

641759

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

High-throughput

0.602

High

926073

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

926093

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

0

High-throughput

0.602

High

926099

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

926101

TSYL6
Testis-specific Y-encoded-like protein 6

2

0

High-throughput

0.602

High

926125

MTG2
Mitochondrial ribosome-associated GTPase 2

2

0

High-throughput

0.585

High

279708

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

926088

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

926112

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.554

High

926129

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

Small-scale

0.554

High

926077

TFAM
Transcription factor A, mitochondrial

2

0

High-throughput

0.547

High

926078

SSBP
Single-stranded DNA-binding protein, mitochondrial

2

0

High-throughput

0.547

High

926109

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

278640

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

289766

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

528433

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.513

High

664528

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.513

High

690472

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

842197

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

869146

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

926094

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

926100

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

0

High-throughput

0.513

High

926107

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

926108

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

926116

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

926117

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.513

High

926132

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

926133

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

926135

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

926137

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

926138

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

926139

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

926142

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.513

High

133234

P2Y10
Putative P2Y purinoceptor 10

1

1

High-throughput

0.489

High

258816

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.489

High

366401

FA12
Coagulation factor XII

1

1

High-throughput

0.489

High

926096

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

Small-scale

0.480

High

281921

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

287263

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

856225

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

926074

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

926080

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

926097

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

926102

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

1

High-throughput

0.479

High

926103

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

926104

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

926111

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

926122

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

926124

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

926134

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

350823

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

470941

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

519081

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

532477

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

559915

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

828718

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841665

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851854

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882604

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

926079

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

926081

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

926082

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

926083

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

926084

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

926086

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

926087

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.458

High

926090

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

926092

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

926105

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

926106

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

926110

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

926115

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

926118

TR61B
tRNA

1

0

High-throughput

0.458

High

926119

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

926120

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.458

High

926121

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

926123

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

926126

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

926128

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

926131

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

926140

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

926085

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

Small-scale

0.445

High

143418

E2F3
Transcription factor E2F3

1

0

Small-scale

0.426

High

371556

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.426

High

926091

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.426

High

926130

TRM1
tRNA

1

0

High-throughput

0.426

High

923574

TTC3
E3 ubiquitin-protein ligase TTC3

1

0

Small-scale

0.288

High

926072

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.282

High

182499

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

260745

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

346923

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

926113

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.279

Low

926127

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.279

Low

926141

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

315325

RECQ4
ATP-dependent DNA helicase Q4

1

0

Small-scale

0.249

Low

926076

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

926095

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

926098

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.249

Low

437650

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

926075

BAT1
b(0,+)-type amino acid transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025