Protein: TF2H4
General transcription factor IIH subunit 4 (Basic transcription factor 2 52 kDa subunit) (BTF2 p52) (General transcription factor IIH polypeptide 4) (TFIIH basal transcription factor complex p52 subunit)

Gene: TF2H4, GTF2H4
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q92759

Gene Ontology (top 5):
GO:0000438 - core TFIIH complex portion of holo TFIIH complex
GO:0000439 - transcription factor TFIIH core complex
GO:0001671 - ATPase activator activity
GO:0003690 - double-stranded DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1257571

TF2H5
General transcription factor IIH subunit 5

8

1

Small-scale

0.972

High

622840

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

9

3

Small-scale

0.971

High

1118847

TF2H3
General transcription factor IIH subunit 3

5

2

Small-scale

0.931

High

897355

CDK7
Cyclin-dependent kinase 7

8

3

High-throughput

0.751

High

1118821

TF2H2
General transcription factor IIH subunit 2

7

3

Small-scale

0.743

High

744678

TF2H1
General transcription factor IIH subunit 1

4

2

Small-scale

0.689

High

1240796

T2H2L
General transcription factor IIH subunit 2-like protein

3

3

High-throughput

0.667

High

1367958

EAF1
ELL-associated factor 1

3

1

High-throughput

0.647

High

908772

MAT1
CDK-activating kinase assembly factor MAT1

2

2

High-throughput

0.601

High

770407

T2FA
General transcription factor IIF subunit 1

2

0

Small-scale

0.592

High

1332089

EIF1A
Probable RNA-binding protein EIF1AD

2

0

High-throughput

0.580

High

628821

TBP
TATA-box-binding protein

1

1

Small-scale

0.550

High

708911

T2EA
General transcription factor IIE subunit 1

1

1

Small-scale

0.550

High

1025132

TF2B
Transcription initiation factor IIB

1

1

Small-scale

0.550

High

396639

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

132503

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.536

High

667385

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.527

High

1141245

BRD3
Bromodomain-containing protein 3

1

2

High-throughput

0.515

High

659546

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

704755

ERCC5
DNA excision repair protein ERCC-5

1

0

High-throughput

0.513

High

1108376

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

Small-scale

0.513

High

1349606

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.513

High

1367960

PRD11
PR domain-containing protein 11

1

0

High-throughput

0.513

High

414327

P53
Cellular tumor antigen p53

1

1

Small-scale

0.501

High

508367

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

611686

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

3

Small-scale

0.500

High

908712

CCNH
Cyclin-H

1

1

Small-scale

0.500

High

674277

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.479

High

897921

CDK9
Cyclin-dependent kinase 9

1

3

High-throughput

0.479

High

1110279

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

High-throughput

0.479

High

1110385

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

2

High-throughput

0.479

High

1110521

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.479

High

1201954

BRDT
Bromodomain testis-specific protein

1

2

High-throughput

0.479

High

242471

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

372734

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

606961

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

696101

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

832932

CETN2
Centrin-2

1

0

High-throughput

0.458

High

854900

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

879321

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

938121

ANM2
Protein arginine N-methyltransferase 2

1

0

High-throughput

0.458

High

1004916

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1088937

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1276574

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1289795

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

1329784

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1367956

ZBT10
Zinc finger and BTB domain-containing protein 10

1

0

Small-scale

0.458

High

1367961

ANLN
Anillin

1

0

High-throughput

0.458

High

1367962

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1367965

RNF11
RING finger protein 11

1

0

Small-scale

0.458

High

173733

BTAF1
TATA-binding protein-associated factor 172

1

0

Small-scale

0.426

High

537630

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

799351

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.426

High

1278778

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.426

High

1356123

THAP3
THAP domain-containing protein 3

2

0

High-throughput

0.322

High

1332146

SR1IP
Protein SREK1IP1

2

0

High-throughput

0.316

High

182703

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

296730

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

718443

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

1027116

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.279

Low

1160922

PRSS8
Prostasin

1

0

High-throughput

0.279

Low

1367963

LCAP
Leucyl-cystinyl aminopeptidase

1

0

High-throughput

0.279

Low

1367966

TLN1
Talin-1

1

0

High-throughput

0.279

Low

346140

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

1360789

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.249

Low

1367957

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1367964

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1367959

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025