Protein: CTSL2
CTD small phosphatase-like protein 2 (CTDSP-like 2) (EC 3.1.3.-)

Gene: CTSL2, CTDSPL2
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q05D32

Gene Ontology (top 5):
GO:0004721 - phosphoprotein phosphatase activity
GO:0005654 - nucleoplasm
GO:0006611 - protein export from nucleus
GO:0008420 - RNA polymerase II CTD heptapeptide repeat phosphatase activity
GO:0030514 - negative regulation of BMP signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1053376

PDK1L
Serine/threonine-protein kinase PDIK1L

7

7

Small-scale

0.747

High

1053378

STK35
Serine/threonine-protein kinase 35

4

3

Small-scale

0.699

High

910861

IMA1
Importin subunit alpha-1

4

4

Small-scale

0.691

High

142534

IMA3
Importin subunit alpha-3

3

4

Small-scale

0.651

High

911219

IMA5
Importin subunit alpha-5

3

4

Small-scale

0.650

High

1053356

CTSL2
CTD small phosphatase-like protein 2

1

6

Small-scale

0.618

High

138671

IMA4
Importin subunit alpha-4

2

4

Small-scale

0.611

High

1053363

IMB1
Importin subunit beta-1

2

1

Small-scale

0.611

High

519490

MYBB
Myb-related protein B

1

1

High-throughput

0.536

High

890307

NU153
Nuclear pore complex protein Nup153

1

6

High-throughput

0.536

High

1053364

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.536

High

1053368

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1053381

MED15
Mediator of RNA polymerase II transcription subunit 15

1

3

High-throughput

0.536

High

854635

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.513

High

890455

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.513

High

171443

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.489

High

658696

JAK1
Tyrosine-protein kinase JAK1

1

5

High-throughput

0.489

High

1053360

MYO1E
Unconventional myosin-Ie

1

1

High-throughput

0.489

High

1053370

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

4

High-throughput

0.489

High

1053375

CPNE8
Copine-8

1

1

High-throughput

0.489

High

1053379

SCYL1
N-terminal kinase-like protein

1

3

High-throughput

0.489

High

1053383

KLF16
Krueppel-like factor 16

1

14

High-throughput

0.489

High

227513

SPOP
Speckle-type POZ protein

1

1

Small-scale

0.481

High

222962

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

253613

IMA7
Importin subunit alpha-7

1

4

Small-scale

0.479

High

256843

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

443327

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.479

High

775028

FUS
RNA-binding protein FUS

1

1

Small-scale

0.479

High

979544

H4
Histone H4

1

1

High-throughput

0.479

High

980713

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

998240

H31
Histone H3.1

1

3

High-throughput

0.479

High

1016795

H33
Histone H3.3

1

3

High-throughput

0.479

High

1053358

ILF2
Interleukin enhancer-binding factor 2

1

1

Small-scale

0.479

High

1053359

ILF3
Interleukin enhancer-binding factor 3

1

1

Small-scale

0.479

High

1053367

ELOC
Elongin-C

1

1

High-throughput

0.479

High

1053373

NIPBL
Nipped-B-like protein

1

4

Small-scale

0.479

High

1053385

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1053387

NCOA3
Nuclear receptor coactivator 3

1

1

Small-scale

0.479

High

214781

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

0

Small-scale

0.458

High

247847

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

487225

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

697085

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

910471

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

Small-scale

0.458

High

1053362

TADBP
TAR DNA-binding protein 43

1

0

Small-scale

0.458

High

1053382

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

293599

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

534967

BIP
Endoplasmic reticulum chaperone BiP

1

2

Small-scale

0.437

High

587632

DESP
Desmoplakin

1

1

Small-scale

0.437

High

693706

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.437

High

940603

ATP5E
ATP synthase F(1) complex subunit epsilon, mitochondrial

1

1

High-throughput

0.437

High

945780

EPIPL
Epiplakin

1

1

Small-scale

0.437

High

1015186

ERH
Enhancer of rudimentary homolog

1

1

Small-scale

0.437

High

1053361

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

3

High-throughput

0.437

High

1053365

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

1053366

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.437

High

1053380

FGD4
FYVE, RhoGEF and PH domain-containing protein 4

1

3

High-throughput

0.437

High

1053384

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

95777

E5RHG8
Elongin-C

1

1

High-throughput

0.407

High

107403

F8W7C6
Ribosomal protein L10

1

1

High-throughput

0.407

High

1053371

AT5EL
ATP synthase subunit epsilon-like protein, mitochondrial

1

1

High-throughput

0.407

High

1053369

PPR29
Protein phosphatase 1 regulatory subunit 29

1

0

High-throughput

0.279

Low

1053374

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.279

Low

1053377

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.279

Low

1053386

IPP
Actin-binding protein IPP

1

0

High-throughput

0.279

Low

105804

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

595752

H13
Histone H1.3

1

0

Small-scale

0.249

Low

772758

MYH9
Myosin-9

1

0

High-throughput

0.249

Low

1039175

RL6
Large ribosomal subunit protein eL6

1

0

Small-scale

0.249

Low

1053357

NU160
Nuclear pore complex protein Nup160

1

0

Small-scale

0.249

Low

1053372

H2A2A
Histone H2A type 2-A

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025