Protein: CPNE8
Copine-8 (Copine VIII)

Gene: CPNE8
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q86YQ8

Gene Ontology (top 5):
GO:0005544 - calcium-dependent phospholipid binding
GO:0005886 - plasma membrane
GO:0046872 - metal ion binding
GO:0070062 - extracellular exosome
GO:0071277 - cellular response to calcium ion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

250283

VINEX
Vinexin

2

3

High-throughput

0.700

High

849202

KSYK
Tyrosine-protein kinase SYK

1

8

High-throughput

0.665

High

375687

RASK
GTPase KRas

3

11

High-throughput

0.640

High

189680

STX7
Syntaxin-7

1

7

High-throughput

0.618

High

226111

STX6
Syntaxin-6

1

1

High-throughput

0.618

High

401094

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.618

High

463628

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.618

High

845710

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.618

High

1004118

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.618

High

1295351

CPNE5
Copine-5

1

16

High-throughput

0.618

High

1295338

T185A
Transmembrane protein 185A

3

1

High-throughput

0.609

High

407650

S100B
Protein S100-B

1

1

High-throughput

0.594

High

374029

RASN
GTPase NRas

2

11

High-throughput

0.584

High

374729

RASH
GTPase HRas

2

10

High-throughput

0.584

High

540544

LAMP1
Lysosome-associated membrane glycoprotein 1

2

1

High-throughput

0.584

High

978134

RHOB
Rho-related GTP-binding protein RhoB

2

10

High-throughput

0.584

High

1295352

ANLN
Anillin

2

2

High-throughput

0.558

High

1295337

NECA1
N-terminal EF-hand calcium-binding protein 1

2

2

High-throughput

0.553

High

882526

ARRB1
Beta-arrestin-1

1

2

High-throughput

0.536

High

1159990

SRSF7
Serine/arginine-rich splicing factor 7

1

0

High-throughput

0.513

High

1295356

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

0

High-throughput

0.513

High

1122280

SCRIB
Protein scribble homolog

1

3

High-throughput

0.501

High

762085

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.493

High

756256

MCM7
DNA replication licensing factor MCM7

1

8

High-throughput

0.489

High

1053375

CTSL2
CTD small phosphatase-like protein 2

1

1

High-throughput

0.489

High

1295334

ZDH23
Palmitoyltransferase ZDHHC23

1

2

High-throughput

0.489

High

126681

RHOD
Rho-related GTP-binding protein RhoD

1

12

High-throughput

0.479

High

218415

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

341098

DIRA3
GTP-binding protein Di-Ras3

1

5

High-throughput

0.479

High

363526

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

466341

RHOC
Rho-related GTP-binding protein RhoC

1

8

High-throughput

0.479

High

562192

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

581151

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.479

High

601358

RHOQ
Rho-related GTP-binding protein RhoQ

1

10

High-throughput

0.479

High

604075

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

630564

RAB3B
Ras-related protein Rab-3B

1

9

High-throughput

0.479

High

630870

RAB4A
Ras-related protein Rab-4A

1

5

High-throughput

0.479

High

631328

RAB5A
Ras-related protein Rab-5A

1

4

High-throughput

0.479

High

774479

BASI
Basigin

1

1

High-throughput

0.479

High

901372

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

901917

RAB9A
Ras-related protein Rab-9A

1

5

High-throughput

0.479

High

910121

RND2
Rho-related GTP-binding protein RhoN

1

14

High-throughput

0.479

High

932095

EPHA4
Ephrin type-A receptor 4

1

5

High-throughput

0.479

High

936377

AFAD
Afadin

1

8

High-throughput

0.479

High

953546

RAC3
Ras-related C3 botulinum toxin substrate 3

1

9

High-throughput

0.479

High

955348

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

962236

RHOA
Transforming protein RhoA

1

9

High-throughput

0.479

High

962780

RND3
Rho-related GTP-binding protein RhoE

1

13

High-throughput

0.479

High

975111

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

976389

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

988500

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.479

High

1015574

RHOG
Rho-related GTP-binding protein RhoG

1

8

High-throughput

0.479

High

1144995

RAB35
Ras-related protein Rab-35

1

4

High-throughput

0.479

High

1147364

EPHA7
Ephrin type-A receptor 7

1

3

High-throughput

0.479

High

1151764

RHOH
Rho-related GTP-binding protein RhoH

1

10

High-throughput

0.479

High

1270888

RHOU
Rho-related GTP-binding protein RhoU

1

15

High-throughput

0.479

High

1295335

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.479

High

1295339

PARD3
Partitioning defective 3 homolog

1

7

High-throughput

0.479

High

1295340

RND1
Rho-related GTP-binding protein Rho6

1

13

High-throughput

0.479

High

1295343

RHOV
Rho-related GTP-binding protein RhoV

1

11

High-throughput

0.479

High

1295345

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1295346

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1295347

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

1295348

RHOJ
Rho-related GTP-binding protein RhoJ

1

10

High-throughput

0.479

High

1295350

RHOF
Rho-related GTP-binding protein RhoF

1

11

High-throughput

0.479

High

1295353

ANFY1
Rabankyrin-5

1

3

High-throughput

0.479

High

1295354

ZO2
Tight junction protein 2

1

4

High-throughput

0.479

High

1295357

ALK
ALK tyrosine kinase receptor

1

7

High-throughput

0.479

High

164378

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

299272

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

605743

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.458

High

715660

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

1041154

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1159737

OCLN
Occludin

1

0

High-throughput

0.458

High

1233320

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1295341

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.458

High

1295344

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

176213

PER2
Period circadian protein homolog 2

1

2

Small-scale

0.437

High

327339

ZFPL1
Zinc finger protein-like 1

1

1

High-throughput

0.437

High

888170

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.437

High

991874

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.437

High

1254498

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1295342

SPDLY
Protein Spindly

1

5

High-throughput

0.437

High

1295355

DNJ5B
DnaJ homolog subfamily C member 5B

1

3

High-throughput

0.437

High

1295358

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

6

High-throughput

0.407

High

1169011

CSPP1
Centrosome and spindle pole-associated protein 1

2

0

High-throughput

0.318

High

1295336

S2541
Mitochondrial carrier protein SCaMC-3L

2

0

High-throughput

0.318

High

1158026

SNPC1
snRNA-activating protein complex subunit 1

1

0

High-throughput

0.279

Low

1224747

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.279

Low

139919

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

847593

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

951248

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

1250165

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

1293055

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1295349

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025