Protein: BRAP
BRCA1-associated protein (EC 2.3.2.27) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (RING-type E3 ubiquitin transferase BRAP2) (Renal carcinoma antigen NY-REN-63)

Gene: BRAP
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q7Z569

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000165 - MAPK cascade
GO:0003676 - nucleic acid binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508202

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

20

Small-scale

0.924

High

1278903

BRAP
BRCA1-associated protein

3

15

Small-scale

0.839

High

970711

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

11

High-throughput

0.698

High

1278921

KLDC3
Kelch domain-containing protein 3

3

5

High-throughput

0.667

High

1278907

KSR1
Kinase suppressor of Ras 1

3

6

Small-scale

0.662

High

507252

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

Small-scale

0.656

High

425554

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.647

High

982223

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

6

High-throughput

0.647

High

995984

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

7

High-throughput

0.647

High

1278937

SPB13
Serpin B13

2

2

High-throughput

0.628

High

799244

BRCA1
Breast cancer type 1 susceptibility protein

2

16

Small-scale

0.619

High

242136

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

1151479

IKBB
NF-kappa-B inhibitor beta

1

9

Small-scale

0.618

High

1154864

NEDD8
Ubiquitin-like protein NEDD8

1

11

Small-scale

0.618

High

1278904

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

6

Small-scale

0.618

High

1278906

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.618

High

211898

PROD
Proline dehydrogenase 1, mitochondrial

2

1

High-throughput

0.611

High

1134627

NUMA1
Nuclear mitotic apparatus protein 1

2

14

Small-scale

0.595

High

1278913

SYNE2
Nesprin-2

2

7

Small-scale

0.595

High

1278931

TANC2
Protein TANC2

1

4

Small-scale

0.587

High

1278922

YJU2
Splicing factor YJU2

2

0

High-throughput

0.580

High

247368

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

8

Small-scale

0.573

High

299717

AKAP3
A-kinase anchor protein 3

1

1

Small-scale

0.573

High

1278939

CC14A
Dual specificity protein phosphatase CDC14A

1

8

Small-scale

0.573

High

1278932

HM20A
High mobility group protein 20A

2

8

Small-scale

0.572

High

1101847

SKP2
S-phase kinase-associated protein 2

1

3

Small-scale

0.561

High

685024

DNMT1
DNA

1

1

Small-scale

0.552

High

1094580

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

17

High-throughput

0.552

High

1278942

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

20

High-throughput

0.552

High

1278912

TRI41
E3 ubiquitin-protein ligase TRIM41

1

16

High-throughput

0.541

High

1278923

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.541

High

1278925

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

20

High-throughput

0.541

High

1112893

CUL2
Cullin-2

1

12

High-throughput

0.536

High

1151963

TWST1
Twist-related protein 1

1

3

Small-scale

0.536

High

374711

RASH
GTPase HRas

1

14

Small-scale

0.534

High

1038315

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

11

Small-scale

0.515

High

1278910

ZN526
Zinc finger protein 526

1

0

High-throughput

0.513

High

1278927

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.513

High

213537

ATMIN
ATM interactor

1

2

Small-scale

0.508

High

387285

APOA1
Apolipoprotein A-I

1

1

Small-scale

0.508

High

1278909

F184A
Protein FAM184A

1

15

Small-scale

0.508

High

1278915

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

6

Small-scale

0.508

High

1278919

ZN382
Zinc finger protein 382

1

2

Small-scale

0.508

High

1278924

SHP1L
Testicular spindle-associated protein SHCBP1L

1

1

Small-scale

0.508

High

1278933

RBM12
RNA-binding protein 12

1

13

Small-scale

0.508

High

1278911

BRK1
Protein BRICK1

1

0

Small-scale

0.486

High

1278917

ZN479
Zinc finger protein 479

1

0

Small-scale

0.486

High

1278918

ZN521
Zinc finger protein 521

1

0

Small-scale

0.486

High

167922

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

10

Small-scale

0.479

High

401058

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

Small-scale

0.479

High

578508

BRAF
Serine/threonine-protein kinase B-raf

1

6

Small-scale

0.479

High

589033

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

695821

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

768533

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

808110

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

Small-scale

0.479

High

1045451

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

1112571

CUL1
Cullin-1

1

12

Small-scale

0.479

High

1113535

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1278905

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1278914

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

3

High-throughput

0.479

High

1278916

OTUL
Ubiquitin thioesterase otulin

1

5

Small-scale

0.479

High

1278920

DNJC2
DnaJ homolog subfamily C member 2

1

5

High-throughput

0.479

High

1278926

WWTR1
WW domain-containing transcription regulator protein 1

1

14

High-throughput

0.479

High

1278928

VP33B
Vacuolar protein sorting-associated protein 33B

1

1

High-throughput

0.479

High

1278929

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1278940

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

4

High-throughput

0.479

High

1218578

CCD30
Coiled-coil domain-containing protein 30

1

15

Small-scale

0.464

High

1278938

FBX2
F-box only protein 2

1

0

Small-scale

0.460

High

939633

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

1278936

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.458

High

1278941

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.458

High

1157788

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.457

High

95895

E7EQL6
Proline dehydrogenase

1

1

High-throughput

0.445

High

425703

LEG2
Galectin-2

1

4

Small-scale

0.437

High

472322

CFAH
Complement factor H

1

2

Small-scale

0.437

High

1278935

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

5

High-throughput

0.437

High

1207366

EFHC1
EF-hand domain-containing protein 1

3

0

Small-scale

0.351

High

1211597

TEX35
Testis-expressed protein 35

1

0

Small-scale

0.265

Low

1278908

TEKL1
Tektin-like protein 1

1

0

Small-scale

0.265

Low

1278930

CPLN1
Ciliogenesis and planar polarity effector 1

1

0

Small-scale

0.238

Low

1278934

FBX28
F-box only protein 28

1

0

Small-scale

0.238

Low


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Last updated: 11Aug2025