Protein: DGKE
Diacylglycerol kinase epsilon (DAG kinase epsilon) (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon)

Gene: DGKE
Organism: Homo sapiens
Interactions: 81
UniProt ID: P52429

Gene Ontology (top 5):
GO:0004143 - ATP-dependent diacylglycerol kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

400517

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.691

High

733731

GRK4
G protein-coupled receptor kinase 4

1

15

High-throughput

0.691

High

911903

JAK3
Tyrosine-protein kinase JAK3

1

15

High-throughput

0.691

High

911982

STYK1
Tyrosine-protein kinase STYK1

1

4

High-throughput

0.691

High

912001

PSKH2
Serine/threonine-protein kinase H2

1

8

High-throughput

0.691

High

912015

SG196
Protein O-mannose kinase

1

0

High-throughput

0.656

High

374485

RASH
GTPase HRas

1

5

Small-scale

0.647

High

411622

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.646

High

911980

NTRK3
NT-3 growth factor receptor

1

5

High-throughput

0.646

High

912014

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.618

High

911998

TSN17
Tetraspanin-17

2

2

High-throughput

0.611

High

901140

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.586

High

407057

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.536

High

732489

ARRB2
Beta-arrestin-2

1

6

High-throughput

0.536

High

882418

ARRB1
Beta-arrestin-1

1

6

High-throughput

0.536

High

911974

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

3

High-throughput

0.536

High

911979

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.536

High

911989

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.536

High

911997

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

912020

GPC5D
G-protein coupled receptor family C group 5 member D

1

8

High-throughput

0.536

High

912022

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

1

High-throughput

0.536

High

912016

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.518

High

911973

SET
Protein SET

1

3

High-throughput

0.515

High

912006

NUF2
Kinetochore protein Nuf2

1

1

High-throughput

0.515

High

911981

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

912013

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

912017

IFT46
Intraflagellar transport protein 46 homolog

1

0

High-throughput

0.513

High

646792

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.493

High

912026

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.493

High

241157

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

588261

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

694987

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

830388

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

911971

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

1

High-throughput

0.479

High

911972

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

911975

CUL3
Cullin-3

1

1

High-throughput

0.479

High

911976

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

4

High-throughput

0.479

High

911994

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.479

High

911996

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

1

High-throughput

0.479

High

911999

TECT2
Tectonic-2

1

1

High-throughput

0.479

High

912004

DERL1
Derlin-1

1

1

High-throughput

0.479

High

912008

BRD8
Bromodomain-containing protein 8

1

3

High-throughput

0.479

High

912018

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.479

High

912023

XPO7
Exportin-7

1

2

High-throughput

0.479

High

912024

AMFR
E3 ubiquitin-protein ligase AMFR

1

4

High-throughput

0.479

High

912025

TRI33
E3 ubiquitin-protein ligase TRIM33

1

4

High-throughput

0.479

High

470937

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.470

High

293405

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

342136

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

418032

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

820612

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.458

High

911987

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

912000

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

912003

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

912007

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

912019

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.458

High

912021

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.458

High

104124

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.445

High

211912

SPIT1
Kunitz-type protease inhibitor 1

1

3

High-throughput

0.445

High

844913

EAA2
Excitatory amino acid transporter 2

1

1

High-throughput

0.445

High

870215

S6A12
Sodium- and chloride-dependent betaine transporter

1

7

High-throughput

0.445

High

870344

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

7

High-throughput

0.445

High

911977

SL9A5
Sodium/hydrogen exchanger 5

1

1

High-throughput

0.445

High

911978

S39AE
Metal cation symporter ZIP14

1

1

High-throughput

0.445

High

911993

S39AB
Zinc transporter ZIP11

1

1

High-throughput

0.445

High

911995

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

912002

SL9A7
Sodium/hydrogen exchanger 7

1

1

High-throughput

0.445

High

912012

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

7

High-throughput

0.445

High

912027

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

911984

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

911992

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

911983

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

911986

S27A1
Long-chain fatty acid transport protein 1

1

0

High-throughput

0.426

High

911991

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

0

High-throughput

0.426

High

912005

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.426

High

911988

HEAT3
HEAT repeat-containing protein 3

2

0

High-throughput

0.313

High

912009

UN93B
Protein unc-93 homolog B1

2

0

High-throughput

0.313

High

911990

IT70A
Intraflagellar transport protein 70A

1

0

High-throughput

0.279

Low

912010

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.249

Low

912011

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

911985

ZNT6
Zinc transporter 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025