Protein: HIG1A
HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a)

Gene: HIG1A, HIGD1A
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q9Y241

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0032991 - protein-containing complex
GO:0042149 - cellular response to glucose starvation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460503

SPB13
Serpin B13

2

0

High-throughput

0.602

High

531178

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

1

High-throughput

0.571

High

1096522

PAK1
Serine/threonine-protein kinase PAK 1

2

2

High-throughput

0.571

High

1110204

HDAC1
Histone deacetylase 1

2

1

High-throughput

0.571

High

1114684

CUL3
Cullin-3

2

0

High-throughput

0.559

High

622487

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.547

High

412830

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.536

High

373529

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.513

High

905708

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

1325411

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.513

High

1449395

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

1

0

High-throughput

0.513

High

922850

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

1

High-throughput

0.489

High

404552

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

1219374

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.479

High

1367618

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1417912

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.479

High

1454402

PAK5
Serine/threonine-protein kinase PAK 5

1

2

High-throughput

0.479

High

1459348

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1460254

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.479

High

1490480

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.479

High

276194

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.458

High

320154

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

343110

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

474384

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.458

High

539023

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

574521

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.458

High

590060

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

626408

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.458

High

696894

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

769543

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

859507

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

885721

CASP4
Caspase-4

1

0

High-throughput

0.458

High

980562

H4
Histone H4

1

0

High-throughput

0.458

High

1117321

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

1138768

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1152499

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.458

High

1161266

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.458

High

1162619

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1290830

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1383283

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1421016

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1435468

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1451430

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

1157117

NTRK3
NT-3 growth factor receptor

1

2

High-throughput

0.457

High

1348662

S7A14
Solute carrier family 7 member 14

1

1

High-throughput

0.445

High

1349174

S2540
Mitochondrial glutathione transporter SLC25A40

1

1

High-throughput

0.445

High

1436972

SFXN1
Sideroflexin-1

1

1

High-throughput

0.445

High

642317

COMT
Catechol O-methyltransferase

1

1

High-throughput

0.437

High

1034207

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

2

High-throughput

0.437

High

1215902

RC3H1
Roquin-1

1

1

High-throughput

0.437

High

1239344

ARMC6
Armadillo repeat-containing protein 6

1

1

High-throughput

0.437

High

1247648

SAMD1
Sterile alpha motif domain-containing protein 1

1

1

High-throughput

0.437

High

1313881

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1355911

DUS19
Dual specificity protein phosphatase 19

1

1

High-throughput

0.437

High

1433477

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.437

High

1438087

RC3H2
Roquin-2

1

1

High-throughput

0.437

High

1490482

PCDBF
Protocadherin beta-15

1

2

High-throughput

0.437

High

1450600

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.426

High

104248

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

188087

MOT5
Monocarboxylate transporter 5

1

3

High-throughput

0.407

High

944103

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.407

High

976879

LCN6
Epididymal-specific lipocalin-6

1

1

High-throughput

0.407

High

1193276

SV2C
Synaptic vesicle glycoprotein 2C

1

2

High-throughput

0.407

High

1271285

SV2B
Synaptic vesicle glycoprotein 2B

1

2

High-throughput

0.407

High

1274107

MOT9
Monocarboxylate transporter 9

1

2

High-throughput

0.407

High

1415054

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

1

High-throughput

0.407

High

318174

IPO13
Importin-13

2

0

High-throughput

0.324

High

1259579

TBA1A
Tubulin alpha-1A chain

2

0

High-throughput

0.307

High

988836

RAC1
Ras-related C3 botulinum toxin substrate 1

2

0

High-throughput

0.298

High

1452560

FA13B
Protein FAM13B

2

0

High-throughput

0.298

High

565740

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.279

Low

653746

PROZ
Vitamin K-dependent protein Z

1

0

High-throughput

0.279

Low

822172

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.279

Low

867525

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

922343

LIMK2
LIM domain kinase 2

1

0

High-throughput

0.279

Low

1142220

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

1395528

M4A4A
Membrane-spanning 4-domains subfamily A member 4A

1

0

High-throughput

0.279

Low

1417390

STK31
Serine/threonine-protein kinase 31

1

0

High-throughput

0.279

Low

1431013

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1448718

LATS2
Serine/threonine-protein kinase LATS2

1

0

High-throughput

0.279

Low

1459563

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.279

Low

156097

SOCS6
Suppressor of cytokine signaling 6

1

0

High-throughput

0.269

Low

1416959

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

317952

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.249

Low

1197756

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1335076

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1391934

RN185
E3 ubiquitin-protein ligase RNF185

1

0

Small-scale

0.249

Low

1397569

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1451322

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

1490481

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1490483

INSI2
Insulin-induced gene 2 protein

1

0

High-throughput

0.249

Low

845162

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.232

Low

848590

MAGA8
Melanoma-associated antigen 8

1

0

High-throughput

0.232

Low

1199762

KLH22
Kelch-like protein 22

1

0

High-throughput

0.232

Low

1325953

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.232

Low

1335437

SPX3
Sugar phosphate exchanger 3

1

0

High-throughput

0.232

Low

1338646

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

0

High-throughput

0.232

Low

1348822

S35G2
Solute carrier family 35 member G2

1

0

High-throughput

0.232

Low

1400783

MYCT
Proton myo-inositol cotransporter

1

0

High-throughput

0.232

Low

1402745

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025