Protein: DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

Gene: DUT
Organism: Homo sapiens
Interactions: 69
UniProt ID: P33316

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001889 - liver development
GO:0003723 - RNA binding
GO:0004170 - dUTP diphosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

751313

RHOB
Rho-related GTP-binding protein RhoB

2

1

Small-scale

0.576

High

371300

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

751347

RHG35
Rho GTPase-activating protein 35

2

0

High-throughput

0.547

High

751351

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.518

High

751353

TLN1
Talin-1

1

1

High-throughput

0.515

High

751319

CUL3
Cullin-3

1

0

High-throughput

0.513

High

240885

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.493

High

751305

STAT3
Signal transducer and activator of transcription 3

1

0

High-throughput

0.493

High

395583

ESR1
Estrogen receptor

1

2

High-throughput

0.481

High

543560

ERR1
Steroid hormone receptor ERR1

1

2

High-throughput

0.481

High

751312

ERR3
Estrogen-related receptor gamma

1

2

High-throughput

0.481

High

466124

RHOC
Rho-related GTP-binding protein RhoC

1

1

High-throughput

0.479

High

751318

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

751330

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.479

High

751333

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.479

High

751340

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.479

High

751346

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

1

Small-scale

0.479

High

297935

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.460

High

128802

MEN1
Menin

1

0

High-throughput

0.458

High

259520

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

315190

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

324583

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

532398

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

751306

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

751308

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

751310

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

751311

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

751320

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

751321

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

751322

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

751323

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

751326

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

751331

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.458

High

751332

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

751334

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

751335

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

751336

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

751337

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

751344

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.458

High

751348

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

751349

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

705251

GRN
Progranulin

1

1

High-throughput

0.445

High

751314

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.445

High

751307

RND2
Rho-related GTP-binding protein RhoN

1

2

High-throughput

0.437

High

751316

RON
Macrophage-stimulating protein receptor

1

1

High-throughput

0.437

High

273402

KDM4A
Lysine-specific demethylase 4A

1

0

Small-scale

0.426

High

404703

PRIO
Major prion protein

1

0

High-throughput

0.426

High

751324

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.426

High

327826

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.407

High

751309

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.407

High

751315

TAGL
Transgelin

1

1

High-throughput

0.407

High

751341

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.407

High

751328

NUD18
8-oxo-dGDP phosphatase NUDT18

2

0

High-throughput

0.334

High

751317

SOS2
Son of sevenless homolog 2

2

0

High-throughput

0.298

High

751325

RHGBB
Inactive Rho GTPase-activating protein 11B

2

0

High-throughput

0.298

High

751343

PKHF2
Pleckstrin homology domain-containing family F member 2

1

0

High-throughput

0.292

High

281291

GGYF1
GRB10-interacting GYF protein 1

1

0

High-throughput

0.279

Low

105443

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

345046

RIGI
Antiviral innate immune response receptor RIG-I

1

0

Small-scale

0.249

Low

377184

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

640110

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.249

Low

751327

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

751338

RHOV
Rho-related GTP-binding protein RhoV

1

0

High-throughput

0.249

Low

751339

RHBT2
Rho-related BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

751342

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

751345

NGB
Neuroglobin

1

0

High-throughput

0.249

Low

751350

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low

751352

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

751329

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025